Regulation of the redox metabolome and thiol proteome by hydrogen sulfide [0.03%]
氢硫化物对细胞氧化还原代谢和硫醇蛋白组的调节作用
Roshan Kumar,Ruma Banerjee
Roshan Kumar
Overproduction of reactive oxygen species and compromised antioxidant defenses perturb intracellular redox homeostasis and is associated with a myriad of human diseases as well as with the natural process of aging. Hydrogen sulfide (H2S), w...
Juan Du,Ke Zhao
Juan Du
Exogenous retroviruses are RNA viruses that require reverse transcription for their replication. Among these viruses, human immunodeficiency virus (HIV) is infectious to humans and causes the development of acquired immune deficiency syndro...
Yasemin Yoluç,Gregor Ammann,Pierre Barraud et al.
Yasemin Yoluç et al.
Organisms from all domains of life invest a substantial amount of energy for the introduction of RNA modifications into nearly all transcripts studied to date. Instrumental analysis of RNA can focus on the modified residues and reveal the f...
Coordinated roles of SLX4 and MutSβ in DNA repair and the maintenance of genome stability [0.03%]
SLX4和MutSβ在DNA修复及基因组稳定性维持中的协调作用
Sarah J Young,Stephen C West
Sarah J Young
SLX4 provides a molecular scaffold for the assembly of multiple protein complexes required for the maintenance of genome stability. It is involved in the repair of DNA crosslinks, the resolution of recombination intermediates, the response ...
Ribonucleotide incorporation into DNA during DNA replication and its consequences [0.03%]
DNA复制过程中的核糖核苷酸的DNA整合及其后果
Zhi-Xiong Zhou,Jessica S Williams,Scott A Lujan et al.
Zhi-Xiong Zhou et al.
Ribonucleotides are the most abundant non-canonical nucleotides in the genome. Their vast presence and influence over genome biology is becoming increasingly appreciated. Here we review the recent progress made in understanding their genomi...
Mobility and disorder in antibody and antigen binding sites do not prevent immunochemical recognition [0.03%]
抗体和抗原结合位点的运动性和无序性并不妨碍免疫化学识别
Vladimir N Uversky,Marc H V Van Regenmortel
Vladimir N Uversky
The known polyspecificity of antibodies, which is crucial for efficient immune response, is determined by the conformational flexibility and intrinsic disorder encoded in local peculiarities of the amino acid sequence of antibodies within o...
The complexity and regulation of repair of alkylation damage to nucleic acids [0.03%]
烷基化损伤的复杂性和修复调控
Ning Tsao,Orlando D Schärer,Nima Mosammaparast
Ning Tsao
DNA damaging agents have been a cornerstone of cancer therapy for nearly a century. The discovery of many of these chemicals, particularly the alkylating agents, are deeply entwined with the development of poisonous materials originally int...
Multifaceted regulation of translation by the epitranscriptomic modification N6-methyladenosine [0.03%]
表观转录组修饰N6-甲基腺苷对翻译的多重调控作用
Xiao-Min Liu,Jun Zhou
Xiao-Min Liu
Translation occurring on cytoplasmic mRNA is precisely governed at three consecutive stages, including initiation, elongation and termination. A growing body of evidence has revealed that an emerging epitranscriptomic code N6-methyladenosin...
To protect and modify double-stranded RNA - the critical roles of ADARs in development, immunity and oncogenesis [0.03%]
保护并编辑双链RNA-ADARs在发育、免疫和肿瘤发生中的重要作用
Emily A Erdmann,Ananya Mahapatra,Priyanka Mukherjee et al.
Emily A Erdmann et al.
Adenosine deaminases that act on RNA (ADARs) are present in all animals and function to both bind double-stranded RNA (dsRNA) and catalyze the deamination of adenosine (A) to inosine (I). As inosine is a biological mimic of guanosine, deami...
HEPN RNases - an emerging class of functionally distinct RNA processing and degradation enzymes [0.03%]
HEPN 核糖核酸酶：一类功能独特的核糖核酸加工和降解酶类
Monica C Pillon,Jacob Gordon,Meredith N Frazier et al.
Monica C Pillon et al.
HEPN (Higher Eukaryotes and Prokaryotes Nucleotide-binding) RNases are an emerging class of functionally diverse RNA processing and degradation enzymes. Members are defined by a small α-helical bundle encompassing a short consensus RNase m...