Xamoterol impairs hippocampus-dependent emotional memory retrieval via Gi/o-coupled β2-adrenergic signaling [0.03%]
Xamoterol通过Gi/o偶联的β2肾上腺素能信号传导损害海马体依赖的情感记忆检索
Keith Schutsky,Ming Ouyang,Steven A Thomas
Keith Schutsky
Xamoterol, a partial β(1)-adrenergic receptor agonist, has been reported to impair the retrieval of hippocampus-dependent spatial reference memory in rats. In contrast, xamoterol restores memory retrieval in gene-targeted mice lacking nore...
Olfactory learning-induced enhancement of the predisposition for LTP induction [0.03%]
嗅觉学习诱导的长时程增强倾向性提升效应
Yaniv Cohen,Sonya Avramoav,Edi Barkai et al.
Yaniv Cohen et al.
Learning of a particularly difficult olfactory-discrimination (OD) task results in acquisition of rule learning. This enhancement in learning capability is accompanied by the long-term enhancement of synaptic connectivity between piriform c...
Epigenetic alterations in the lateral amygdala are required for reconsolidation of a Pavlovian fear memory [0.03%]
外侧杏仁体的表观遗传改变是巴甫洛夫恐惧记忆再巩固所必需的
Stephanie A Maddox,Glenn E Schafe
Stephanie A Maddox
Epigenetic mechanisms have been widely implicated in synaptic plasticity and in memory consolidation, yet little is known about the role of epigenetic mechanisms in memory reconsolidation processes. In the present study, we systematically e...
RSK2 signaling in brain habenula contributes to place aversion learning [0.03%]
脑缰核中的RSK2信号通路参与位置厌恶学习
Emmanuel Darcq,Pascale Koebel,Carolina Del Boca et al.
Emmanuel Darcq et al.
RSK2 is a Ser/Thr kinase acting in the Ras/MAPK pathway. Rsk2 gene deficiency leads to the Coffin-Lowry Syndrome, notably characterized by cognitive deficits. We found that mrsk2 knockout mice are unable to associate an aversive stimulus wi...
Effects of modality on the neural correlates of encoding processes supporting recollection and familiarity [0.03%]
模态对回忆和熟悉性表征的神经机制的影响
Lauren J Gottlieb,Michael D Rugg
Lauren J Gottlieb
Prior research has demonstrated that the neural correlates of successful encoding ("subsequent memory effects") partially overlap with neural regions selectively engaged by the on-line demands of the study task. The primary goal of the pres...
Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density [0.03%]
雷林蛋白补充改善认知能力、突触可塑性及树突棘密度
Justin T Rogers,Ian Rusiana,Justin Trotter et al.
Justin T Rogers et al.
Apolipoprotein receptors belong to an evolutionarily conserved surface receptor family that has intimate roles in the modulation of synaptic plasticity and is necessary for proper hippocampal-dependent memory formation. The known lipoprotei...
Extinction partially reverts structural changes associated with remote fear memory [0.03%]
消退部分逆转远程恐惧记忆相关的结构变化
Gisella Vetere,Leonardo Restivo,Giovanni Novembre et al.
Gisella Vetere et al.
Structural synaptic changes occur in medial prefrontal cortex circuits during remote memory formation. Whether extinction reverts or further reshapes these circuits is, however, unknown. Here we show that the number and the size of spines w...
Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms [0.03%]
利用NMDA受体和内源大麻素依赖机制的双向关联神经信号变化
Qin Li,Brian D Burrell
Qin Li
Persistent, bidirectional changes in synaptic signaling (that is, potentiation and depression of the synapse) can be induced by the precise timing of individual pre- and postsynaptic action potentials. However, far less attention has been p...
Working memory deficits, increased anxiety-like traits, and seizure susceptibility in BDNF overexpressing mice [0.03%]
脑源性神经营养因子过度表达小鼠工作记忆缺失、焦虑样行为增加和易惊厥性增强
Francesco Papaleo,Jill L Silverman,Jordan Aney et al.
Francesco Papaleo et al.
BDNF regulates components of cognitive processes and has been implicated in psychiatric disorders. Here we report that genetic overexpression of the BDNF mature isoform (BDNF-tg) in female mice impaired working memory functions while sparin...
Intra-amygdala ZIP injections impair the memory of learned active avoidance responses and attenuate conditioned taste-aversion acquisition in rats [0.03%]
杏仁体内注射ZIP影响大鼠习得性积极回避反应和削弱条件性味觉厌恶学习
Fernando Gámiz,Milagros Gallo
Fernando Gámiz
We have investigated the effect of protein kinase Mzeta (PKMζ) inhibition in the basolateral amygdala (BLA) upon the retention of a nonspatial learned active avoidance response and conditioned taste-aversion (CTA) acquisition in rats. ZIP ...