Familiar taste induces higher dendritic levels of activity-regulated cytoskeleton-associated protein in the insular cortex than a novel one [0.03%]
熟悉味道比新奇味道能诱导岛皮层中活动调节细胞骨架相关蛋白的树突水平更高
Jean-Pascal Morin,Cesar Quiroz,Lucia Mendoza-Viveros et al.
Jean-Pascal Morin et al.
The immediate early gene (IEG) Arc is known to play an important role in synaptic plasticity; its protein is locally translated in the dendrites where it has been involved in several types of plasticity mechanisms. Because of its tight coup...
Running is the neurogenic and neurotrophic stimulus in environmental enrichment [0.03%]
跑步通过神经生成和神经营养作用改善环境富集的效果
Tali Kobilo,Qing-Rong Liu,Kriti Gandhi et al.
Tali Kobilo et al.
Environmental enrichment (EE) increases dentate gyrus (DG) neurogenesis and brain-derived neurotrophic factor (BDNF) levels. However, running is considered an element of EE. To dissociate effects of physical activity and enrichment on hippo...
Xamoterol impairs hippocampus-dependent emotional memory retrieval via Gi/o-coupled β2-adrenergic signaling [0.03%]
Xamoterol通过Gi/o偶联的β2肾上腺素能信号传导损害海马体依赖的情感记忆检索
Keith Schutsky,Ming Ouyang,Steven A Thomas
Keith Schutsky
Xamoterol, a partial β(1)-adrenergic receptor agonist, has been reported to impair the retrieval of hippocampus-dependent spatial reference memory in rats. In contrast, xamoterol restores memory retrieval in gene-targeted mice lacking nore...
Olfactory learning-induced enhancement of the predisposition for LTP induction [0.03%]
嗅觉学习诱导的长时程增强倾向性提升效应
Yaniv Cohen,Sonya Avramoav,Edi Barkai et al.
Yaniv Cohen et al.
Learning of a particularly difficult olfactory-discrimination (OD) task results in acquisition of rule learning. This enhancement in learning capability is accompanied by the long-term enhancement of synaptic connectivity between piriform c...
Epigenetic alterations in the lateral amygdala are required for reconsolidation of a Pavlovian fear memory [0.03%]
外侧杏仁体的表观遗传改变是巴甫洛夫恐惧记忆再巩固所必需的
Stephanie A Maddox,Glenn E Schafe
Stephanie A Maddox
Epigenetic mechanisms have been widely implicated in synaptic plasticity and in memory consolidation, yet little is known about the role of epigenetic mechanisms in memory reconsolidation processes. In the present study, we systematically e...
RSK2 signaling in brain habenula contributes to place aversion learning [0.03%]
脑缰核中的RSK2信号通路参与位置厌恶学习
Emmanuel Darcq,Pascale Koebel,Carolina Del Boca et al.
Emmanuel Darcq et al.
RSK2 is a Ser/Thr kinase acting in the Ras/MAPK pathway. Rsk2 gene deficiency leads to the Coffin-Lowry Syndrome, notably characterized by cognitive deficits. We found that mrsk2 knockout mice are unable to associate an aversive stimulus wi...
Effects of modality on the neural correlates of encoding processes supporting recollection and familiarity [0.03%]
模态对回忆和熟悉性表征的神经机制的影响
Lauren J Gottlieb,Michael D Rugg
Lauren J Gottlieb
Prior research has demonstrated that the neural correlates of successful encoding ("subsequent memory effects") partially overlap with neural regions selectively engaged by the on-line demands of the study task. The primary goal of the pres...
Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density [0.03%]
雷林蛋白补充改善认知能力、突触可塑性及树突棘密度
Justin T Rogers,Ian Rusiana,Justin Trotter et al.
Justin T Rogers et al.
Apolipoprotein receptors belong to an evolutionarily conserved surface receptor family that has intimate roles in the modulation of synaptic plasticity and is necessary for proper hippocampal-dependent memory formation. The known lipoprotei...
Extinction partially reverts structural changes associated with remote fear memory [0.03%]
消退部分逆转远程恐惧记忆相关的结构变化
Gisella Vetere,Leonardo Restivo,Giovanni Novembre et al.
Gisella Vetere et al.
Structural synaptic changes occur in medial prefrontal cortex circuits during remote memory formation. Whether extinction reverts or further reshapes these circuits is, however, unknown. Here we show that the number and the size of spines w...
Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms [0.03%]
利用NMDA受体和内源大麻素依赖机制的双向关联神经信号变化
Qin Li,Brian D Burrell
Qin Li
Persistent, bidirectional changes in synaptic signaling (that is, potentiation and depression of the synapse) can be induced by the precise timing of individual pre- and postsynaptic action potentials. However, far less attention has been p...