Dopamine induces LTP differentially in apical and basal dendrites through BDNF and voltage-dependent calcium channels [0.03%]
多巴胺通过BDNF和电压依赖性钙通道在树突的不同部分诱导长时程增强作用
Sheeja Navakkode,Sreedharan Sajikumar,Martin Korte et al.
Sheeja Navakkode et al.
The dopaminergic modulation of long-term potentiation (LTP) has been studied well, but the mechanism by which dopamine induces LTP (DA-LTP) in CA1 pyramidal neurons is unknown. Here, we report that DA-LTP in basal dendrites is dependent whi...
Kv4 potassium channels modulate hippocampal EPSP-spike potentiation and spatial memory in rats [0.03%]
Kv4钾通道调节大鼠海马EPSP- spikes增强和空间记忆
Bruno Truchet,Christine Manrique,Leam Sreng et al.
Bruno Truchet et al.
Kv4 channels regulate the backpropagation of action potentials (b-AP) and have been implicated in the modulation of long-term potentiation (LTP). Here we showed that blockade of Kv4 channels by the scorpion toxin AmmTX3 impaired reference m...
Molecular and behavioral changes associated with adult hippocampus-specific SynGAP1 knockout [0.03%]
成人海马特异型SynGAP1敲除相关的分子和行为改变
Mary Muhia,Silvia Willadt,Benjamin K Yee et al.
Mary Muhia et al.
The synaptic Ras/Rap-GTPase-activating protein (SynGAP1) plays a unique role in regulating specific downstream intracellular events in response to N-methyl-D-aspartate receptor (NMDAR) activation. Constitutive heterozygous loss of SynGAP1 d...
Involvement of spindles in memory consolidation is slow wave sleep-specific [0.03%]
纺锤波参与记忆巩固与慢波睡眠有关
Roy Cox,Winni F Hofman,Lucia M Talamini
Roy Cox
Both sleep spindles and slow oscillations have been implicated in sleep-dependent memory consolidation. Whereas spindles occur during both light and deep sleep, slow oscillations are restricted to deep sleep, raising the possibility of grea...
Post-training unilateral amygdala lesions selectively impair contextual fear memories [0.03%]
训练后的单侧杏仁核损伤选择性地损害了情境恐惧记忆
Charlotte R Flavell,Jonathan L C Lee
Charlotte R Flavell
The basolateral amygdala (BLA) and the dorsal hippocampus (dHPC) are both structures with key roles in contextual fear conditioning. During fear conditioning, it is postulated that contextual representations of the environment are formed in...
The effect of interference on temporal order memory for random and fixed sequences in nondemented older adults [0.03%]
干扰对非痴呆老年人随机序列和固定序列时间顺序记忆的影响
Jerlyn C Tolentino,Eva Pirogovsky,Trinh Luu et al.
Jerlyn C Tolentino et al.
Two experiments tested the effect of temporal interference on order memory for fixed and random sequences in young adults and nondemented older adults. The results demonstrate that temporal order memory for fixed and random sequences is imp...
Medial prefrontal cortex is selectively involved in response selection using visual context in the background [0.03%]
视稳态下视觉背景信息加工中的前额叶功能连接及个体差异
Inah Lee,Ji Yun Shin
Inah Lee
The exact roles of the medial prefrontal cortex (mPFC) in conditional choice behavior are unknown and a visual contextual response selection task was used for examining the issue. Inactivation of the mPFC severely disrupted performance in t...
Lucia M Talamini,Eva Gorree
Lucia M Talamini
Some memories about events can persist for decades, even a lifetime. However, recent memories incorporate rich sensory information, including knowledge on the spatial and temporal ordering of event features, while old memories typically lac...
Post-acquisition release of glutamate and norepinephrine in the amygdala is involved in taste-aversion memory consolidation [0.03%]
杏仁体中味觉厌恶记忆巩固与谷氨酸和去甲肾上腺素的释放有关
Kioko Guzmán-Ramos,Daniel Osorio-Gómez,Perla Moreno-Castilla et al.
Kioko Guzmán-Ramos et al.
Amygdala activity mediates the acquisition and consolidation of emotional experiences; we have recently shown that post-acquisition reactivation of this structure is necessary for the long-term storage of conditioned taste aversion (CTA). H...
Reduced spiking in entorhinal cortex during the delay period of a cued spatial response task [0.03%]
在空间反应任务延迟期脑皮质神经元放电减少
Kishan Gupta,Lauren A Keller,Michael E Hasselmo
Kishan Gupta
Intrinsic persistent spiking mechanisms in medial entorhinal cortex (mEC) neurons may play a role in active maintenance of working memory. However, electrophysiological studies of rat mEC units have primarily focused on spatial modulation. ...