Onset and offset of aversive events establish distinct memories requiring fear and reward networks [0.03%]
涉及恐惧和奖励神经网络的回避性事件发生与结束所建立的不同记忆
Marta Andreatta,Markus Fendt,Andreas Mühlberger et al.
Marta Andreatta et al.
Two things are worth remembering about an aversive event: What made it happen? What made it cease? If a stimulus precedes an aversive event, it becomes a signal for threat and will later elicit behavior indicating conditioned fear. However,...
Medial prefrontal lesions in mice impair sustained attention but spare maintenance of information in working memory [0.03%]
小鼠内侧前额叶损伤损害持续注意力但不影响工作记忆的信息保持功能
Julia B Kahn,Ryan D Ward,Lora W Kahn et al.
Julia B Kahn et al.
Working memory and attention are complex cognitive functions that are disrupted in several neuropsychiatric disorders. Mouse models of such human diseases are commonly subjected to maze-based tests that can neither distinguish between these...
Localization of molecular correlates of memory consolidation to buccal ganglia mechanoafferent neurons after learning that food is inedible in Aplysia [0.03%]
Localization of molecular correlates of memory consolidation to cerebral mechanoafferent neurons after learning that food is inedible in Aplysia 在海兔中，学习到食物不可食用后，记忆巩固的分子相关物定位在脑神经节机械感受器神经元中
David Levitan,Ravit Saada-Madar,Anastasiya Teplinsky et al.
David Levitan et al.
Training paradigms affecting Aplysia withdrawal reflexes cause changes in gene expression leading to long-term memory formation in primary mechanoafferents that initiate withdrawal. Similar mechanoafferents are also found in the buccal gang...
Olfactory bulb α2-adrenoceptor activation promotes rat pup odor-preference learning via a cAMP-independent mechanism [0.03%]
olfactory bulbα2-肾上腺素受体的激活通过cAMP非依赖机制促进幼鼠对尿液气味偏好的学习
Amin M D Shakhawat,Carolyn W Harley,Qi Yuan
Amin M D Shakhawat
In this study, three lines of evidence suggest a role for α(2)-adrenoreceptors in rat pup odor-preference learning: olfactory bulb infusions of the α(2)-antagonist, yohimbine, prevents learning; the α(2)-agonist, clonidine, paired with o...
Administration of the phosphodiesterase type 4 inhibitor rolipram into the amygdala at a specific time interval after learning increases recognition memory persistence [0.03%]
杏仁体内给予磷酸二酯酶类型4抑制剂Rolipram以特定的时间间隔给药可增加识别记忆的持续性
Aline Werenicz,Raissa R Christoff,Martina Blank et al.
Aline Werenicz et al.
Here we show that administration of the phosphodiesterase type 4 (PDE4) inhibitor rolipram into the basolateral complex of the amygdala (BLA) at a specific time interval after training enhances memory consolidation and induces memory persis...
Brain region-specific activity patterns after recent or remote memory retrieval of auditory conditioned fear [0.03%]
近期或远期听觉条件性恐惧记忆提取后的脑区特异性激活模式
Jeong-Tae Kwon,Jinho Jhang,Hyung-Su Kim et al.
Jeong-Tae Kwon et al.
Memory is thought to be sparsely encoded throughout multiple brain regions forming unique memory trace. Although evidence has established that the amygdala is a key brain site for memory storage and retrieval of auditory conditioned fear me...
The GABAergic anterior paired lateral neurons facilitate olfactory reversal learning in Drosophila [0.03%]
Drosophila谷氨酸氨基乙酸神经元通过GABA能前连对侧神经元促进嗅觉逆转学习
Yanying Wu,Qingzhong Ren,Hao Li et al.
Yanying Wu et al.
Reversal learning has been widely used to probe the implementation of cognitive flexibility in the brain. Previous studies in monkeys identified an essential role of the orbitofrontal cortex (OFC) in reversal learning. However, the underlyi...
A role of protein degradation in memory consolidation after initial learning and extinction learning in the honeybee (Apis mellifera) [0.03%]
蜜蜂学习和消退后的记忆巩固中蛋白质降解的作用研究
Johannes Felsenberg,Vincent Dombrowski,Dorothea Eisenhardt
Johannes Felsenberg
Protein degradation is known to affect memory formation after extinction learning. We demonstrate here that an inhibitor of protein degradation, MG132, interferes with memory formation after extinction learning in a classical appetitive con...
D-cycloserine does not facilitate fear extinction by reducing conditioned stimulus processing or promoting conditioned inhibition to contextual cues [0.03%]
D-环丝氨酸不会通过减少条件性刺激处理或促进上下文线索的条件性抑制来促进恐惧消退
Kathryn D Baker,Gavan P McNally,Rick Richardson
Kathryn D Baker
The NMDA receptor partial agonist d-cycloserine (DCS) enhances the extinction of learned fear in rats and exposure therapy in humans with anxiety disorders. Despite these benefits, little is known about the mechanisms by which DCS promotes ...
Restoration of dopamine release deficits during object recognition memory acquisition attenuates cognitive impairment in a triple transgenic mice model of Alzheimer's disease [0.03%]
在三转基因阿尔茨海默病小鼠模型中，恢复奖赏释放不足可减轻物体识别记忆获得过程中的认知障碍
Kioko Guzmán-Ramos,Perla Moreno-Castilla,Monica Castro-Cruz et al.
Kioko Guzmán-Ramos et al.
Previous findings indicate that the acquisition and consolidation of recognition memory involves dopaminergic activity. Although dopamine deregulation has been observed in Alzheimer's disease (AD) patients, the dysfunction of this neurotran...