Ontogeny of contextual fear memory formation, specificity, and persistence in mice [0.03%]
小鼠情境恐惧记忆的形成、特异性和持久性的发展过程
Katherine G Akers,Maithe Arruda-Carvalho,Sheena A Josselyn et al.
Katherine G Akers et al.
Pinpointing the precise age when young animals begin to form memories of aversive events is valuable for understanding the onset of anxiety and mood disorders and for detecting early cognitive impairment in models of childhood-onset disorde...
Vanesa M Fernández,Martin Giurfa,Jean-Marc Devaud et al.
Vanesa M Fernández et al.
Latent inhibition (LI) is a decrement in learning performance that results from the nonreinforced pre-exposure of the to-be-conditioned stimulus, in both vertebrates and invertebrates. In vertebrates, LI development involves dopamine and se...
Differential roles for Nr4a1 and Nr4a2 in object location vs. object recognition long-term memory [0.03%]
Nr4a1和Nr4a2在物体位置记忆与物体识别记忆中的不同作用
Susan E McNulty,Ruth M Barrett,Annie Vogel-Ciernia et al.
Susan E McNulty et al.
Nr4a1 and Nr4a2 are transcription factors and immediate early genes belonging to the nuclear receptor Nr4a family. In this study, we examine their role in long-term memory formation for object location and object recognition. Using siRNA to...
The episodic engram transformed: Time reduces retrieval-related brain activity but correlates it with memory accuracy [0.03%]
时间重塑回溯相关脑活动但与记忆准确性呈正相关
Orit Furman,Avi Mendelsohn,Yadin Dudai
Orit Furman
We took snapshots of human brain activity with fMRI during retrieval of realistic episodic memory over several months. Three groups of participants were scanned during a memory test either hours, weeks, or months after viewing a documentary...
Fan-shaped body neurons are involved in period-dependent regulation of long-term courtship memory in Drosophila [0.03%]
扇形体神经元参与调节果蝇长期求偶记忆的周期依赖性
Takaomi Sakai,Show Inami,Shoma Sato et al.
Takaomi Sakai et al.
In addition to its established function in the regulation of circadian rhythms, the Drosophila gene period (per) also plays an important role in processing long-term memory (LTM). Here, we used courtship conditioning as a learning paradigm ...
Age-dependent deficits in fear learning in heterozygous BDNF knock-out mice [0.03%]
BDNF基因杂合敲除小鼠恐惧学习的年龄相关缺陷
Thomas Endres,Volkmar Lessmann
Thomas Endres
Beyond its trophic function, the neurotrophin BDNF (brain-derived neurotrophic factor) is well known to crucially mediate synaptic plasticity and memory formation. Whereas recent studies suggested that acute BDNF/TrkB signaling regulates am...
MSK1 regulates environmental enrichment-induced hippocampal plasticity and cognitive enhancement [0.03%]
环境富集诱导的海马可塑性和认知改善由MSK1调节
Kate Karelina,Katelin F Hansen,Yun-Sik Choi et al.
Kate Karelina et al.
Environmental enrichment (EE) has marked beneficial effects on cognitive capacity. Given the possibility that this form of neuronal plasticity could function via the actuation of the same cellular signaling pathways that underlie learning/m...
Jenny Aino Plath,Johannes Felsenberg,Dorothea Eisenhardt
Jenny Aino Plath
During extinction animals experience that the previously learned association between a conditioned stimulus (CS) and an unconditioned stimulus (US) no longer holds true. Accordingly, the conditioned response (CR) to the CS decreases. This d...
Conversion of short-term potentiation to long-term potentiation in mouse CA1 by coactivation of β-adrenergic and muscarinic receptors [0.03%]
β肾上腺素能受体和毒蕈碱受体共同激活将短期增强转换成长时程增强效应
Steven A Connor,Sabyasachi Maity,Birbickram Roy et al.
Steven A Connor et al.
Encoding new information requires dynamic changes in synaptic strength. The brain can boost synaptic plasticity through the secretion of neuromodulatory substances, including acetylcholine and noradrenaline. Considerable effort has focused ...
Procedural learning and associative memory mechanisms contribute to contextual cueing: Evidence from fMRI and eye-tracking [0.03%]
基于fMRI和眼动的证据揭示程序性学习和联想记忆机制促进情境诱引效应
Anna Manelis,Lynne M Reder
Anna Manelis
Using a combination of eye tracking and fMRI in a contextual cueing task, we explored the mechanisms underlying the facilitation of visual search for repeated spatial configurations. When configurations of distractors were repeated, greater...