The medial prefrontal cortex is critical for memory retrieval and resolving interference [0.03%]
内侧前额叶皮层对于记忆提取和解决干扰至关重要
Gregory J Peters,Christopher N David,Madison D Marcus et al.
Gregory J Peters et al.
The prefrontal cortex (PFC) is known to be critically involved in strategy switching, attentional set shifting, and inhibition of prepotent responses. A central feature of this kind of behavioral flexibility is the ability to resolve confli...
EGFR signaling in the brain is necessary for olfactory learning in Drosophila larvae [0.03%]
脑中的表皮生长因子受体信号在果蝇幼虫嗅觉学习中是必须的
Tasja Rahn,Matthias Leippe,Thomas Roeder et al.
Tasja Rahn et al.
Signaling via the epidermal growth factor receptor (EGFR) pathway has emerged as one of the key mechanisms in the development of the central nervous system in Drosophila melanogaster. By contrast, little is known about the functions of EGFR...
Age-related cognitive impairments in mice with a conditional ablation of the neural cell adhesion molecule [0.03%]
条件性消除神经细胞粘附分子小鼠的认知功能老化损伤
Reto Bisaz,Pere Boadas-Vaello,David Genoux et al.
Reto Bisaz et al.
Most of the mechanisms involved in neural plasticity support cognition, and aging has a considerable effect on some of these processes. The neural cell adhesion molecule (NCAM) of the immunoglobulin superfamily plays a pivotal role in struc...
Traces of memory: reacquisition of fear following forgetting is NMDAr-independent [0.03%]
记忆的痕迹：遗忘后的恐惧再现无需NMDA受体参与
Stella Li,Rick Richardson
Stella Li
Recent research shows that while initial learning is dependent on N-methyl-D-aspartate receptors (NMDArs), relearning can be NMDAr-independent. In the present study we examined whether this switch also occurs following forgetting. The devel...
Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory [0.03%]
背侧前楔叶皮层在恐惧记忆巩固和提取中的功能完整性作用
Cynthia Katche,Guido Dorman,Leandro Slipczuk et al.
Cynthia Katche et al.
Memory storage is a temporally graded process involving different phases and different structures in the mammalian brain. Cortical plasticity is essential to store stable memories, but little is known regarding its involvement in memory pro...
Brian R Cornwell,Cassie Overstreet,Marissa Krimsky et al.
Brian R Cornwell et al.
Conventional wisdom dictates we must face our fears to conquer them. This idea is embodied in exposure-based treatments for anxiety disorders, where the intent of exposure is to reverse a history of avoidant behavior that is thought to fuel...
Exposure to a fearful context during periods of memory plasticity impairs extinction via hyperactivation of frontal-amygdalar circuits [0.03%]
在记忆可塑性时期接触恐惧情境通过过度激活前额叶-杏仁体环路损害消退反应
James M Stafford,DeeAnna K Maughan,Elena C Ilioi et al.
James M Stafford et al.
An issue of increasing theoretical and translational importance is to understand the conditions under which learned fear can be suppressed, or even eliminated. Basic research has pointed to extinction, in which an organism is exposed to a f...
Estradiol-induced object recognition memory consolidation is dependent on activation of mTOR signaling in the dorsal hippocampus [0.03%]
雌二醇诱导的对象识别记忆巩固依赖于海马背侧mTOR信号的激活
Ashley M Fortress,Lu Fan,Patrick T Orr et al.
Ashley M Fortress et al.
The mammalian target of rapamycin (mTOR) signaling pathway is an important regulator of protein synthesis and is essential for various forms of hippocampal memory. Here, we asked whether the enhancement of object recognition memory consolid...
Cell-type specific inactivation of hippocampal CA1 disrupts location-dependent object recognition in the mouse [0.03%]
小鼠海马CA1特异性神经元簇的细胞类型特定失活会破坏基于位置的目标识别记忆
Jakob Haettig,Yanjun Sun,Marcelo A Wood et al.
Jakob Haettig et al.
The allatostatin receptor (AlstR)/ligand inactivation system enables potent regulation of neuronal circuit activity. To examine how different cell types participate in memory formation, we have used this system through Cre-directed, cell-ty...
Conflict between place and response navigation strategies: effects on vicarious trial and error (VTE) behaviors [0.03%]
空间策略与反应策略的冲突对替代尝试行为(VTE)的影响
Brandy Schmidt,Andrew Papale,A David Redish et al.
Brandy Schmidt et al.
Navigation can be accomplished through multiple decision-making strategies, using different information-processing computations. A well-studied dichotomy in these decision-making strategies compares hippocampal-dependent "place" and dorsal-...