Reexposure to the amnestic agent alleviates cycloheximide-induced retrograde amnesia for reactivated and extinction memories [0.03%]
胺抗剂的再暴露缓解了环己酰亚胺引起的重新激活和消退记忆的逆行性遗忘
James F Briggs,Brian P Olson
James F Briggs
We investigated whether reexposure to an amnestic agent would reverse amnesia for extinction of learned fear similar to that of a reactivated memory. When cycloheximide (CHX) was administered immediately after a brief cue-induced memory rea...
Activation of β2-adrenoceptor enhances synaptic potentiation and behavioral memory via cAMP-PKA signaling in the medial prefrontal cortex of rats [0.03%]
β2肾上腺素受体活化通过cAMP-PKA信号增强大鼠前额叶皮层的突触强化和行为记忆
Hou-Cheng Zhou,Yan-Yan Sun,Wei Cai et al.
Hou-Cheng Zhou et al.
The prefrontal cortex (PFC) plays a critical role in cognitive functions, including working memory, attention regulation, behavioral inhibition, as well as memory storage. The functions of PFC are very sensitive to norepinephrine (NE), and ...
Disruption of the perineuronal net in the hippocampus or medial prefrontal cortex impairs fear conditioning [0.03%]
海马或前额叶皮质的神经外网破坏会损害恐惧条件反射
Michael J Hylin,Sara A Orsi,Anthony N Moore et al.
Michael J Hylin et al.
The perineuronal net (PNN) surrounds neurons in the central nervous system and is thought to regulate developmental plasticity. A few studies have shown an involvement of the PNN in hippocampal plasticity and memory storage in adult animals...
Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex [0.03%]
携带APOE4基因的年轻小鼠出现空间学习和记忆能力差及内侧嗅皮质树突棘密度降低的现象
Gustavo A Rodriguez,Mark P Burns,Edwin J Weeber et al.
Gustavo A Rodriguez et al.
The apolipoprotein E4 (APOE-ε4) allele is the strongest genetic risk factor for developing late-onset Alzheimer's disease, and may predispose individuals to Alzheimer's-related cognitive decline by affecting normal brain function early in ...
A BDNF sensitive mechanism is involved in the fear memory resulting from the interaction between stress and the retrieval of an established trace [0.03%]
一种BDNF敏感机制参与了应激与已建立痕迹提取交互作用产生的恐惧记忆形成
Marcelo Giachero,Silvia G Bustos,Gaston Calfa et al.
Marcelo Giachero et al.
The present study investigates the fear memory resulting from the interaction of a stressful experience and the retrieval of an established fear memory trace. Such a combination enhanced both fear expression and fear retention in adult Wist...
Delaying interference training has equivalent effects in various Pavlovian interference paradigms [0.03%]
延迟干扰训练在各种巴甫洛夫干扰范式中具有相当的效果
Elizabeth J Powell,Martha Escobar,Whitney Kimble
Elizabeth J Powell
Spontaneous recovery in extinction appears to be inversely related to the acquisition-to-extinction interval, but it remains unclear why this is the case. Rat subjects trained with one of three interference paradigms exhibited less spontane...
Activation of BDNF signaling prevents the return of fear in female mice [0.03%]
脑源性神经营养因子信号通路的激活可预防雌性小鼠恐惧复发
Danay Baker-Andresen,Charlotte R Flavell,Xiang Li et al.
Danay Baker-Andresen et al.
There are significant sex differences in vulnerability to develop fear-related anxiety disorders. Females exhibit twice the rate of post-traumatic stress disorder (PTSD) as males and sex differences have been observed in fear extinction lea...
Vishnu P Murty,Ian C Ballard,Katherine E Macduffie et al.
Vishnu P Murty et al.
Novelty detection, a critical computation within the medial temporal lobe (MTL) memory system, necessarily depends on prior experience. The current study used functional magnetic resonance imaging (fMRI) in humans to investigate dynamic cha...
Neural correlates of appetitive-aversive interactions in Pavlovian fear conditioning [0.03%]
巴甫洛夫恐惧条件反射中的 appetitive-aversive 交互的神经相关因素
Helen M Nasser,Gavan P McNally
Helen M Nasser
We used Pavlovian counterconditioning in rats to identify the neural mechanisms for appetitive-aversive motivational interactions. In Stage I, rats were trained on conditioned stimulus (CS)-food (unconditioned stimulus [US]) pairings. In St...
Enhanced noradrenergic activity potentiates fear memory consolidation and reconsolidation by differentially recruiting α1- and β-adrenergic receptors [0.03%]
肾上腺素能活性增强通过分别募集α1-和β-肾上腺素受体来加强恐惧记忆的巩固和再巩固
Lucas Gazarini,Cristina A Jark Stern,Antônio P Carobrez et al.
Lucas Gazarini et al.
Consolidation and reconsolidation are phases of memory stabilization that diverge slightly. Noradrenaline is known to influence both processes, but the relative contribution of α1- and β-adrenoceptors is unclear. The present study sought ...