Differential needs of zinc in the CA3 area of dorsal hippocampus for the consolidation of contextual fear and spatial memories [0.03%]
海马背CA3区锌离子在恐惧记忆和空间记忆巩固中的不同作用需求
Johnatan Ceccom,Emilie Bouhsira,Hélène Halley et al.
Johnatan Ceccom et al.
One peculiarity of the hippocampal CA3 mossy fiber terminals is the co-release of zinc and glutamate upon synaptic transmission. How these two players act on hippocampal-dependent memories is still unclear. To decipher their respective invo...
Cerebellar deep nuclei involvement in cognitive adaptation and automaticity [0.03%]
小脑深核在认知适应和自动化中的作用
Delphine Callu,Joëlle Lopez,Nicole El Massioui
Delphine Callu
To determine the role of the interpositus nuclei of cerebellum in rule-based learning and optimization processes, we studied (1) successive transfers of an initially acquired response rule in a cross maze and (2) behavioral strategies in le...
Hippocampus and medial prefrontal cortex contributions to trace and contextual fear memory expression over time [0.03%]
时间推移下海马和中前额皮质对痕迹型和情境型恐惧记忆的贡献
Christopher L Beeman,Philip S Bauer,Jamie L Pierson et al.
Christopher L Beeman et al.
Previous work has shown that damage to the dorsal hippocampus (DH) occurring at recent, but not remote, timepoints following acquisition produces a deficit in trace conditioned fear memory expression. The opposite pattern has been observed ...
The beneficial effects of leptin on REM sleep deprivation-induced cognitive deficits in mice [0.03%]
关于瘦素对睡眠剥夺所致小鼠认知缺损的有益作用
Hsiao-Fu Chang,Chun-Lin Su,Chih-Hua Chang et al.
Hsiao-Fu Chang et al.
Leptin, a 167 amino acid peptide, is synthesized predominantly in the adipose tissues and plays a key role in the regulation of food intake and body weight. Recent studies indicate that leptin receptor is expressed with high levels in many ...
Implication of dopaminergic modulation in operant reward learning and the induction of compulsive-like feeding behavior in Aplysia [0.03%]
多巴胺能调节在Operant奖励学习以及Aplysia类强迫行为进食诱导中的影响
Alexis Bédécarrats,Charles Cornet,John Simmers et al.
Alexis Bédécarrats et al.
Feeding in Aplysia provides an amenable model system for analyzing the neuronal substrates of motivated behavior and its adaptability by associative reward learning and neuromodulation. Among such learning processes, appetitive operant cond...
Karen L Montey,Nicolette C Eaton,Elizabeth M Quinlan
Karen L Montey
Severe amblyopia, characterized by a significant reduction in visual acuity through the affected eye, is highly resistant to reversal in adulthood. We have previously shown that synaptic plasticity can be reactivated in the adult rat visual...
Post-retrieval late process contributes to persistence of reactivated fear memory [0.03%]
获取后的晚期加工促进了恢复的恐惧记忆的保持
Daisuke Nakayama,Yoshiko Yamasaki,Norio Matsuki et al.
Daisuke Nakayama et al.
Several studies have demonstrated the mechanisms involved in memory persistence after learning. However, little is known about memory persistence after retrieval. In this study, a protein synthesis inhibitor, anisomycin, was infused into th...
17β-estradiol is necessary for extinction of cocaine seeking in female rats [0.03%]
雌性大鼠可卡因觅药的消退需要雌二醇的作用
Robert C Twining,Jennifer J Tuscher,Elizabeth M Doncheck et al.
Robert C Twining et al.
Human and preclinical models of addiction demonstrate that gonadal hormones modulate acquisition of drug seeking. Little is known, however, about the effects of these hormones on extinction of drug-seeking behavior. Here, we investigated ho...
Differential recruitment of distinct amygdalar nuclei across appetitive associative learning [0.03%]
不同类型杏仁核神经元在经典条件反射中的动态招募机制不同
Sindy Cole,Daniel J Powell,Gorica D Petrovich
Sindy Cole
The amygdala is important for reward-associated learning, but how distinct cell groups within this heterogeneous structure are recruited during appetitive learning is unclear. Here we used Fos induction to map the functional amygdalar circu...
NR2A- and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioning [0.03%]
NR2A和NR2B型NMDAR在前额叶皮层对痕迹、延缓以及情境恐惧条件反射的不同调节作用
Marieke R Gilmartin,Janine L Kwapis,Fred J Helmstetter
Marieke R Gilmartin
Activation of N-methyl-D-aspartate receptors (NMDAR) in the prelimbic medial prefrontal cortex (PL mPFC) is necessary for the acquisition of both trace and contextual fear memories, but it is not known how specific NR2 subunits support each...