Inactivation of medial prefrontal cortex or acute stress impairs odor span in rats [0.03%]
内侧前额叶失活或急性压力可损害大鼠的气味跨度能力
Don A Davies,Joel J Molder,Quentin Greba et al.
Don A Davies et al.
The capacity of working memory is limited and is altered in brain disorders including schizophrenia. In rodent working memory tasks, capacity is typically not measured (at least not explicitly). One task that does measure working memory cap...
Soyun Kim,Grégoire Borst,William L Thompson et al.
Soyun Kim et al.
In four experiments, we explored the capacity for spatial mental imagery in patients with hippocampal lesions, using tasks that minimized the role of learning and memory. On all four tasks, patients with hippocampal lesions performed as wel...
A secondary working memory challenge preserves primary place strategies despite overtraining [0.03%]
次要的工作记忆挑战能够在过度训练的情况下保留主要的位置策略
Robert S Gardner,Michael R Uttaro,Samantha E Fleming et al.
Robert S Gardner et al.
Learning by repetition engages distinct cognitive strategies whose contributions are adjusted with experience. Early in learning, performance relies upon flexible, attentive strategies. With extended practice, inflexible, automatic strategi...
Long-term exercise is needed to enhance synaptic plasticity in the hippocampus [0.03%]
长期锻炼能增强海马区的突触可塑性
Anna R Patten,Helle Sickmann,Brett N Hryciw et al.
Anna R Patten et al.
Exercise can have many benefits for the body, but it also benefits the brain by increasing neurogenesis, synaptic plasticity, and performance on learning and memory tasks. The period of exercise needed to realize the structural and function...
Neuronal correlates of fear conditioning in the bed nucleus of the stria terminalis [0.03%]
终纹带状核中条件恐惧的神经相关性
Darrell Haufler,Frank Z Nagy,Denis Pare
Darrell Haufler
Lesion and inactivation studies indicate that the central amygdala (CeA) participates in the expression of cued and contextual fear, whereas the bed nucleus of the stria terminalis (BNST) is only involved in the latter. The basis for this f...
Sex differences in the generalization of fear as a function of retention intervals [0.03%]
恐惧泛化的性别差异：不同保持间隔下的作用机制
Joseph Lynch rd,Patrick K Cullen,Aaron M Jasnow et al.
Joseph Lynch rd et al.
In previous studies using male rodents, context change disrupted a fear response at a short, but not a long, retention interval. Here, we examined the effects of context changes on fear responses as a function of time in male and female rat...
Dopamine D1 sensitivity in the prefrontal cortex predicts general cognitive abilities and is modulated by working memory training [0.03%]
预 frontal皮质多巴胺D1受体敏感性预测总体认知能力并被工作记忆训练调节
Christopher Wass,Alessandro Pizzo,Bruno Sauce et al.
Christopher Wass et al.
A common source of variance (i.e., "general intelligence") underlies an individual's performance across diverse tests of cognitive ability, and evidence indicates that the processing efficacy of working memory may serve as one such source o...
Hippocampal structural plasticity accompanies the resulting contextual fear memory following stress and fear conditioning [0.03%]
应激和恐惧条件作用后伴随发生的 контекстуальная панич症记忆的海马结构性可塑性
Marcelo Giachero,Gaston D Calfa,Victor A Molina
Marcelo Giachero
The present research investigated the resulting contextual fear memory and structural plasticity changes in the dorsal hippocampus (DH) following stress and fear conditioning. This combination enhanced fear retention and increased the numbe...
A pencil rescues impaired performance on a visual discrimination task in patients with medial temporal lobe lesions [0.03%]
铅笔帮助海马受损患者改善视觉辨别任务中的表现
Ashley R Knutson,Ramona O Hopkins,Larry R Squire
Ashley R Knutson
We tested proposals that medial temporal lobe (MTL) structures support not just memory but certain kinds of visual perception as well. Patients with hippocampal lesions or larger MTL lesions attempted to identify the unique object among twi...
Ioana Marin,Jonathan Kipnis
Ioana Marin
The nervous system and the immune system are two main regulators of homeostasis in the body. Communication between them ensures normal functioning of the organism. Immune cells and molecules are required for sculpting the circuitry and dete...