The ubiquitin-specific protease 14 (USP14) is a critical regulator of long-term memory formation [0.03%]
泛素特异性蛋白酶14（USP14）是长期记忆形成的重要调节因子
Timothy J Jarome,Janine L Kwapis,Jada J Hallengren et al.
Timothy J Jarome et al.
Numerous studies have suggested a role for ubiquitin-proteasome-mediated protein degradation in learning-dependent synaptic plasticity; however, very little is known about how protein degradation is regulated at the level of the proteasome ...
Stress reduces the incorporation of misinformation into an established memory [0.03%]
压力会减少错误信息进入 established 记忆中
Pia-Isabell Schmidt,Kristin Rosga,Celina Schatto et al.
Pia-Isabell Schmidt et al.
Memory can be distorted by misleading post-event information. These memory distortions may have serious consequences, for example in eyewitness testimony. Many situations in which memory reports are solicited, and suggestive or misleading i...
Randomized Controlled Trial
Learning & memory (Cold Spring Harbor, N.Y.). 2013 Dec 16;21(1):5-8. DOI:10.1101/lm.033043.113 2013
Makoto Kondo,Yukiko Nakamura,Yusuke Ishida et al.
Makoto Kondo et al.
The 5-HT3 receptor, the only ionotropic 5-HT receptor, is expressed in limbic regions, including the hippocampus, amygdala, and cortex. However, it is not known whether it has a role in fear memory processes. Analysis of 5-HT3A receptor kno...
CGRP antagonist infused into the bed nucleus of the stria terminalis impairs the acquisition and expression of context but not discretely cued fear [0.03%]
作用于终纹床核的CGRP受体拮抗剂会削弱情境但不会削弱信号恐惧的获得和表达
Kelly S Sink,Michael Davis,David L Walker
Kelly S Sink
Calcitonin gene-related peptide (CGRP) infusions into the bed nucleus of the stria terminalis (BNST) evoke increases in startle amplitude and increases in anxiety-like behavior in the plus maze. Conversely, intra-BNST infusions of the CGRP ...
Adult neurogenesis in the mammalian hippocampus: why the dentate gyrus? [0.03%]
哺乳动物海马区的神经发生：为什么是齿状回？
Liam J Drew,Stefano Fusi,René Hen
Liam J Drew
In the adult mammalian brain, newly generated neurons are continuously incorporated into two networks: interneurons born in the subventricular zone migrate to the olfactory bulb, whereas the dentate gyrus (DG) of the hippocampus integrates ...
Stephanie Braun,Wolfgang Hauber
Stephanie Braun
Here we examined effects of acute stressors that involve either systemic coadministration of corticosterone/yohimbine (3 mg/kg each) to increase glucocorticoid/noradrenaline activity (denoted as "pharmacological" stressor) or one or several...
The selectivity of aversive memory reconsolidation and extinction processes depends on the initial encoding of the Pavlovian association [0.03%]
厌恶性记忆再巩固和消退的选择性依赖于最初形成的经典条件反射编码状态
Jacek Debiec,Lorenzo Diaz-Mataix,David E A Bush et al.
Jacek Debiec et al.
In reconsolidation studies, memories are typically retrieved by an exposure to a single conditioned stimulus (CS). We have previously demonstrated that reconsolidation processes are CS-selective, suggesting that memories retrieved by the CS...
DREAM/calsenilin/KChIP3 modulates strategy selection and estradiol-dependent learning and memory [0.03%]
DREAM/calsenilin/KChIP3调节策略选择和雌二醇依赖的学习记忆
Tumay Tunur,Claire E Stelly,Laura Ann Schrader
Tumay Tunur
Downstream regulatory element antagonist modulator (DREAM)/calsenilin(C)/K⁺ channel interacting protein 3 (KChIP3) is a multifunctional Ca²⁺-binding protein highly expressed in the hippocampus that inhibits hippocampus-sensitive memory a...
Randomized Controlled Trial
Learning & memory (Cold Spring Harbor, N.Y.). 2013 Nov 18;20(12):686-94. DOI:10.1101/lm.032052.113 2013
Carolyn E Jones,Stephanie Ringuet,Marie-H Monfils
Carolyn E Jones
Pairing a previously neutral conditioned stimulus (CS; e.g., a tone) to an aversive unconditioned stimulus (US; e.g., a footshock) leads to associative learning such that the tone alone comes to elicit a conditioned response (e.g., freezing...
Deletion of PTEN produces deficits in conditioned fear and increases fragile X mental retardation protein [0.03%]
PTEN基因缺失导致条件性恐惧缺陷和FMR1蛋白增加
Joaquin N Lugo,Gregory D Smith,Jessica B Morrison et al.
Joaquin N Lugo et al.
The phosphatase and tensin homolog detected on chromosome 10 (PTEN) gene product modulates activation of the phosphatidylinositol 3-kinase (PI3K)/AKT pathway. The PI3K pathway has been found to be involved in the regulation of the fragile X...