Dysgranular retrosplenial cortex lesions in rats disrupt cross-modal object recognition [0.03%]
大鼠扣带回后部非颗粒区损伤会破坏跨模式物体识别能力
Emma L Hindley,Andrew J D Nelson,John P Aggleton et al.
Emma L Hindley et al.
The retrosplenial cortex supports navigation, with one role thought to be the integration of different spatial cue types. This hypothesis was extended by examining the integration of nonspatial cues. Rats with lesions in either the dysgranu...
Learning enhances intrinsic excitability in a subset of lateral amygdala neurons [0.03%]
学习提高外侧杏仁核部分神经元的内在兴奋性
Megha Sehgal,Vanessa L Ehlers,James R Moyer Jr
Megha Sehgal
Learning-induced modulation of neuronal intrinsic excitability is a metaplasticity mechanism that can impact the acquisition of new memories. Although the amygdala is important for emotional learning and other behaviors, including fear and ...
D1/D5 receptors and histone deacetylation mediate the Gateway Effect of LTP in hippocampal dentate gyrus [0.03%]
海马齿状回长时程增强的门户效应依赖于D1/D5受体和组蛋白去乙酰化作用
Yan-You Huang,Amir Levine,Denise B Kandel et al.
Yan-You Huang et al.
The dentate gyrus (DG) of the hippocampus is critical for spatial memory and is also thought to be involved in the formation of drug-related associative memory. Here, we attempt to test an aspect of the Gateway Hypothesis, by studying the e...
Heidi C Meyer,David J Bucci
Heidi C Meyer
Previous studies have examined the maturation of learning and memory abilities during early stages of development. By comparison, much less is known about the ontogeny of learning and memory during later stages of development, including ado...
Eran Dayan,Bruno B Averbeck,Barry J Richmond et al.
Eran Dayan et al.
Learning complex skills is driven by reinforcement, which facilitates both online within-session gains and retention of the acquired skills. Yet, in ecologically relevant situations, skills are often acquired when mapping between actions an...
Stella Li,Bridget L Callaghan,Rick Richardson
Stella Li
Unlike adult memories that can be remembered for many years, memories that are formed early in life are more fragile and susceptible to being forgotten (a phenomenon known as "infantile" or "childhood" amnesia). Nonetheless, decades of rese...
The less things change, the more they are different: contributions of long-term synaptic plasticity and homeostasis to memory [0.03%]
变化越少，区别越大：长期突触可塑性和稳态在记忆中的作用
Samuel Schacher,Jiang-Yuan Hu
Samuel Schacher
An important cellular mechanism contributing to the strength and duration of memories is activity-dependent alterations in the strength of synaptic connections within the neural circuit encoding the memory. Reversal of the memory is typical...
AMPK agonist AICAR improves cognition and motor coordination in young and aged mice [0.03%]
增敏剂AICAR可改善年轻和年老小鼠的认知力和运动协调性
Tali Kobilo,Davide Guerrieri,Yongqing Zhang et al.
Tali Kobilo et al.
Normal aging can result in a decline of memory and muscle function. Exercise may prevent or delay these changes. However, aging-associated frailty can preclude physical activity. In young sedentary animals, pharmacological activation of AMP...
Learning to ignore: a modeling study of a decremental cholinergic pathway and its influence on attention and learning [0.03%]
学习忽略：一个递减的胆碱能通路及其对注意力和学习影响的建模研究
Nicolas Oros,Andrea A Chiba,Douglas A Nitz et al.
Nicolas Oros et al.
Learning to ignore irrelevant stimuli is essential to achieving efficient and fluid attention, and serves as the complement to increasing attention to relevant stimuli. The different cholinergic (ACh) subsystems within the basal forebrain r...
Activity-dependent changes in MAPK activation in the Angelman Syndrome mouse model [0.03%]
安吉尔曼综合征鼠模型中活动依赖性的MAPK活化变化
Irina Filonova,Justin H Trotter,Jessica L Banko et al.
Irina Filonova et al.
Angelman Syndrome (AS) is a devastating neurological disorder caused by disruption of the maternal UBE3A gene. Ube3a protein is identified as an E3 ubiquitin ligase that shows neuron-specific imprinting. Despite extensive research evaluatin...