Acquisition of conditioned responding in a multiple schedule depends on the reinforcement's temporal contingency with each stimulus [0.03%]
条件刺激与强化的时间一致性依赖于多变量安排中的条件反应的获得
Lorenzo Morè,Greg Jensen
Lorenzo Morè
Forty mice acquired conditioned responses to stimuli presented in a multiple schedule with variable inter-trial intervals (ITIs). In some trials, reinforcement was preceded by a variable conditioned stimulus (CS), while other trials were re...
Early-life cocaine interferes with BDNF-mediated behavioral plasticity [0.03%]
早年期可卡因通过干扰脑源性神经营养因子介导的行为可塑性产生长期影响
Elizabeth A Hinton,Marina G Wheeler,Shannon L Gourley
Elizabeth A Hinton
An important aspect of goal-directed action selection is differentiating between actions that are more or less likely to be reinforced. With repeated performance or psychostimulant exposure, however, actions can assume stimulus-elicited-or ...
Pain-relief learning in flies, rats, and man: basic research and applied perspectives [0.03%]
从果蝇、大鼠到人：疼痛缓解学习的基本研究与应用展望
Bertram Gerber,Ayse Yarali,Sören Diegelmann et al.
Bertram Gerber et al.
Memories relating to a painful, negative event are adaptive and can be stored for a lifetime to support preemptive avoidance, escape, or attack behavior. However, under unfavorable circumstances such memories can become overwhelmingly power...
Behavioral flexibility is increased by optogenetic inhibition of neurons in the nucleus accumbens shell during specific time segments [0.03%]
.optogenetically抑制伏隔核壳部神经元可提高特定时间片段的行为灵活性
Luca Aquili,Andrew W Liu,Mayumi Shindou et al.
Luca Aquili et al.
Behavioral flexibility is vital for survival in an environment of changing contingencies. The nucleus accumbens may play an important role in behavioral flexibility, representing learned stimulus-reward associations in neural activity durin...
A novel cysteine-rich neurotrophic factor in Aplysia facilitates growth, MAPK activation, and long-term synaptic facilitation [0.03%]
一种新的半胱氨酸丰富的神经营养因子通过促进生长、MAPK激活和长期突触增强来参与海兔神经系统功能调控
Lu Pu,Ashley M Kopec,Heather D Boyle et al.
Lu Pu et al.
Neurotrophins are critically involved in developmental processes such as neuronal cell survival, growth, and differentiation, as well as in adult synaptic plasticity contributing to learning and memory. Our previous studies examining neurot...
Genetic variation in COMT activity impacts learning and dopamine release capacity in the striatum [0.03%]
COMT活性的基因多态性影响学习和纹状体多巴胺释放能力
Eleanor H Simpson,Julia Morud,Vanessa Winiger et al.
Eleanor H Simpson et al.
A common genetic polymorphism that results in increased activity of the dopamine regulating enzyme COMT (the COMT Val(158) allele) has been found to associate with poorer cognitive performance and increased susceptibility to develop psychia...
Activity-dependent inhibitory gating in molecular signaling cascades induces a novel form of intermediate-term synaptic facilitation in Aplysia californica [0.03%]
活化依赖的抑制性门控可诱导海兔Aplysia californica分子信号转导级联产生一种新型中程突触强化形式
Soren Fischbach,Ashley M Kopec,Thomas J Carew
Soren Fischbach
Mechanistically distinct forms of long-lasting plasticity and memory can be induced by a variety of different training patterns. Although several studies have identified distinct molecular pathways that are engaged during these different tr...
Sleep benefits in parallel implicit and explicit measures of episodic memory [0.03%]
睡眠对事件记忆内隐和外显度量的益处：平行研究
Frederik D Weber,Jing-Yi Wang,Jan Born et al.
Frederik D Weber et al.
Research in rats using preferences during exploration as a measure of memory has indicated that sleep is important for the consolidation of episodic-like memory, i.e., memory for an event bound into specific spatio-temporal context. How the...
The orexin component of fasting triggers memory processes underlying conditioned food selection in the rat [0.03%]
饥饿引起的下丘脑分泌素成分诱发了调节条件化食物选择的中枢记忆过程
Barbara Ferry,Patricia Duchamp-Viret
Barbara Ferry
To test the selectivity of the orexin A (OXA) system in olfactory sensitivity, the present study compared the effects of fasting and of central infusion of OXA on the memory processes underlying odor-malaise association during the condition...
GABA-mediated presynaptic inhibition is required for precision of long-term memory [0.03%]
GABA介导的突触前抑制作用对长期记忆的精确性是必需的
Patrick K Cullen,Brooke N Dulka,Samantha Ortiz et al.
Patrick K Cullen et al.
Though much attention has been given to the neural structures that underlie the long-term consolidation of contextual memories, little is known about the mechanisms responsible for the maintenance of memory precision. Here, we demonstrate a...