Connecting model species to nature: predator-induced long-term sensitization in Aplysia californica [0.03%]
从模式生物到自然：Aplysia californica 的捕食者诱导的长期敏感性
Maria J Mason,Amanda J Watkins,Jordann Wakabayashi et al.
Maria J Mason et al.
Previous research on sensitization in Aplysia was based entirely on unnatural noxious stimuli, usually electric shock, until our laboratory found that a natural noxious stimulus, a single sublethal lobster attack, causes short-term sensitiz...
NMDA receptor- and ERK-dependent histone methylation changes in the lateral amygdala bidirectionally regulate fear memory formation [0.03%]
侧杏仁体的NMDA受体和ERK依赖的组蛋白甲基化变化双向调节恐惧记忆形成
Swati Gupta-Agarwal,Timothy J Jarome,Jordan Fernandez et al.
Swati Gupta-Agarwal et al.
It is well established that fear memory formation requires de novo gene transcription in the amygdala. We provide evidence that epigenetic mechanisms in the form of histone lysine methylation in the lateral amygdala (LA) are regulated by NM...
Inhibition of estradiol synthesis impairs fear extinction in male rats [0.03%]
雌二醇合成受抑会影响雄性大鼠的恐惧消退作用
Bronwyn M Graham,Mohammed R Milad
Bronwyn M Graham
Emerging research has demonstrated that the sex hormone estradiol regulates fear extinction in female rodents and women. Estradiol may also regulate fear extinction in males, given its role in synaptic plasticity in both sexes. Here we repo...
Repetition strengthens target recognition but impairs similar lure discrimination: evidence for trace competition [0.03%]
重复增强目标识别但损害类似诱因的辨别：痕迹竞争的证据
Zachariah M Reagh,Michael A Yassa
Zachariah M Reagh
Most theories of memory assume that representations are strengthened with repetition. We recently proposed Competitive Trace Theory, building on the hippocampus' powerful capacity to orthogonalize inputs into distinct outputs. We hypothesiz...
Young and old Pavlovian fear memories can be modified with extinction training during reconsolidation in humans [0.03%]
人在重组过程中通过消退训练可以改变年轻和年老的经典恐惧记忆
Elisa C K Steinfurth,Jonathan W Kanen,Candace M Raio et al.
Elisa C K Steinfurth et al.
Extinction training during reconsolidation has been shown to persistently diminish conditioned fear responses across species. We investigated in humans if older fear memories can benefit similarly. Using a Pavlovian fear conditioning paradi...
Randomized Controlled Trial
Learning & memory (Cold Spring Harbor, N.Y.). 2014 Jun 16;21(7):338-41. DOI:10.1101/lm.033589.113 2014
Voluntary exercise improves performance of a discrimination task through effects on the striatal dopamine system [0.03%]
自愿锻炼通过影响纹状体多巴胺系统来改善辨别任务的表现
Meghan C Eddy,Katherine J Stansfield,John T Green
Meghan C Eddy
We have previously demonstrated that voluntary exercise facilitates discrimination learning in a modified T-maze. There is evidence implicating the dorsolateral striatum (DLS) as the substrate for this task. The present experiments examined...
The eIF2α kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression [0.03%]
EIF2α激酶PERK限制海马元体谷氨酸受体依赖的长期压抑的表达
Mimi A Trinh,Tao Ma,Hanoch Kaphzan et al.
Mimi A Trinh et al.
The proper regulation of translation is required for the expression of long-lasting synaptic plasticity. A major site of translational control involves the phosphorylation of eukaryotic initiation factor 2 α (eIF2α) by PKR-like endoplasmi...
A specific role for hippocampal mossy fiber's zinc in rapid storage of emotional memories [0.03%]
海马苔藓纤维锌在情绪记忆快速存储中的特定作用
Johnatan Ceccom,Hélène Halley,Stéphanie Daumas et al.
Johnatan Ceccom et al.
We investigated the specific role of zinc present in large amounts in the synaptic vesicles of mossy fibers and coreleased with glutamate in the CA3 region. In previous studies, we have shown that blockade of zinc after release has no effec...
Cyclic nucleotide-gated channels, calmodulin, adenylyl cyclase, and calcium/calmodulin-dependent protein kinase II are required for late, but not early, long-term memory formation in the honeybee [0.03%]
环核苷酸门控通道、钙调蛋白、腺苷酸环化酶和钙/钙调素依赖性蛋白激酶II是晚长期记忆但不是早长期记忆形成所需要的条件
Yukihisa Matsumoto,Jean-Christophe Sandoz,Jean-Marc Devaud et al.
Yukihisa Matsumoto et al.
Memory is a dynamic process that allows encoding, storage, and retrieval of information acquired through individual experience. In the honeybee Apis mellifera, olfactory conditioning of the proboscis extension response (PER) has shown that ...
Regulation of persistent activity in hippocampal mossy cells by inhibitory synaptic potentials [0.03%]
抑制性突触电位调节海马苔藓细胞的持续活动
Ross W Anderson,Ben W Strowbridge
Ross W Anderson
The hippocampal formation receives strong cholinergic input from the septal/diagonal band complex. Although the functional effects of cholinergic activation have been extensively studied in pyramidal neurons within the hippocampus and entor...