17β-Estradiol regulates histone alterations associated with memory consolidation and increases Bdnf promoter acetylation in middle-aged female mice [0.03%]
雌二醇调节与记忆巩固相关的组蛋白修饰并增加中年母鼠Bdnf启动子乙酰化水平
Ashley M Fortress,Jaekyoon Kim,Rachel L Poole et al.
Ashley M Fortress et al.
Histone acetylation is essential for hippocampal memory formation in young adult rodents. Although dysfunctional histone acetylation has been associated with age-related memory decline in male rodents, little is known about whether histone ...
Retrieval is not necessary to trigger reconsolidation of object recognition memory in the perirhinal cortex [0.03%]
纹状回不需要检索即可触发物体识别记忆的再巩固现象
Marianela Santoyo-Zedillo,Carlos J Rodriguez-Ortiz,Gianfranco Chavez-Marchetta et al.
Marianela Santoyo-Zedillo et al.
Memory retrieval has been considered as requisite to initiate memory reconsolidation; however, some studies indicate that blocking retrieval does not prevent memory from undergoing reconsolidation. Since N-methyl-D-aspartate (NMDA) and α-a...
Sunbin Song,Leonardo Cohen
Sunbin Song
Humans and other mammals learn sequences of movements by splitting them into smaller "chunks." Such chunks are defined by the faster speed of performance of groups of movements. The purpose of this report is to determine how conscious inten...
A unifying model of the role of the infralimbic cortex in extinction and habits [0.03%]
前扣带回在消退和习惯中的统一模型
Jacqueline M Barker,Jane R Taylor,L Judson Chandler
Jacqueline M Barker
The infralimbic prefrontal cortex (IL) has been shown to be critical for the regulation of flexible behavior, but its precise function remains unclear. This region has been shown to be critical for the acquisition, consolidation, and expres...
A review on human reinstatement studies: an overview and methodological challenges [0.03%]
人类复现研究综述：概览与方法挑战
Jan Haaker,Armita Golkar,Dirk Hermans et al.
Jan Haaker et al.
In human research, studies of return of fear (ROF) phenomena, and reinstatement in particular, began only a decade ago and recently are more widely used, e.g., as outcome measures for fear/extinction memory manipulations (e.g., reconsolidat...
Genetic disruption of the core circadian clock impairs hippocampus-dependent memory [0.03%]
遗传破坏核心昼夜钟表损害海马依赖记忆
Sarah M Wardlaw,Trongha X Phan,Amit Saraf et al.
Sarah M Wardlaw et al.
Perturbing the circadian system by electrolytically lesioning the suprachiasmatic nucleus (SCN) or varying the environmental light:dark schedule impairs memory, suggesting that memory depends on the circadian system. We used a genetic appro...
Modulation of olfactory bulb network activity by serotonin: synchronous inhibition of mitral cells mediated by spatially localized GABAergic microcircuits [0.03%]
五羟色胺对嗅球网络活动的调节作用：通过空间局部化的GABA能微环路同步抑制颗粒细胞
Loren J Schmidt,Ben W Strowbridge
Loren J Schmidt
Although inhibition has often been proposed as a central mechanism for coordinating activity in the olfactory system, relatively little is known about how activation of different inhibitory local circuit pathways can generate coincident inh...
Philip A Vieira,Jonathan W Lovelace,Alex Corches et al.
Philip A Vieira et al.
The neural mechanisms underlying the attainment of fear memory accuracy for appropriate discriminative responses to aversive and nonaversive stimuli are unclear. Considerable evidence indicates that coactivator of transcription and histone ...
Delay and trace fear conditioning in C57BL/6 and DBA/2 mice: issues of measurement and performance [0.03%]
C57BL/6和DBA/2小鼠延迟恐惧条件反射和痕迹恐惧条件反射的测量问题及表现形式
Megan E Tipps,Jonathan D Raybuck,Kari J Buck et al.
Megan E Tipps et al.
Strain comparison studies have been critical to the identification of novel genetic and molecular mechanisms in learning and memory. However, even within a single learning paradigm, the behavioral data for the same strain can vary greatly, ...
Contralateral disconnection of the rat prelimbic cortex and dorsomedial striatum impairs cue-guided behavioral switching [0.03%]
损毁大鼠前额叶皮层和背内侧纹状体的联络纤维会损害基于线索的行为转换能力
Phillip M Baker,Michael E Ragozzino
Phillip M Baker
Switches in reward outcomes or reward-predictive cues are two fundamental ways in which information is used to flexibly shift response patterns. The rat prelimbic cortex and dorsomedial striatum support behavioral flexibility based on a cha...