Tugba Guven-Ozkan,Ronald L Davis
Tugba Guven-Ozkan
New approaches, techniques and tools invented over the last decade and a half have revolutionized the functional dissection of neural circuitry underlying Drosophila learning. The new methodologies have been used aggressively by researchers...
Beyond the bolus: transgenic tools for investigating the neurophysiology of learning and memory [0.03%]
超越团块：探究学习和记忆神经生理学的转基因工具
Christine Lykken,Clifford G Kentros
Christine Lykken
Understanding the neural mechanisms underlying learning and memory in the entorhinal-hippocampal circuit is a central challenge of systems neuroscience. For more than 40 years, electrophysiological recordings in awake, behaving animals have...
Evan S Hill,Angela M Bruno,William N Frost
Evan S Hill
Voltage-sensitive dye (VSD) imaging is a powerful technique that can provide, in single experiments, a large-scale view of network activity unobtainable with traditional sharp electrode recording methods. Here we review recent work using VS...
Monkeys rely on recency of stimulus repetition when solving short-term memory tasks [0.03%]
猕猴在完成短期记忆任务时依靠刺激重复的近因效应
John H Wittig Jr,Barry J Richmond
John H Wittig Jr
Seven monkeys performed variants of two short-term memory tasks that others have used to differentiate between selective and nonselective memory mechanisms. The first task was to view a list of sequentially presented images and identify whe...
Xavier De Jaeger,Julie Courtey,Maïna Brus et al.
Xavier De Jaeger et al.
Reconsolidation is necessary for the restabilization of reactivated memory traces. However, experimental parameters have been suggested as boundary conditions for this process. Here we investigated the role of a spatial memory trace's age, ...
Anisomycin injection in area CA3 of the hippocampus impairs both short-term and long-term memories of contextual fear [0.03%]
安iszomycin注射到海马CA3区既损害情境恐惧的短时记忆又损害长时记忆
Jessica Remaud,Johnatan Ceccom,Julien Carponcy et al.
Jessica Remaud et al.
Protein synthesis is involved in the consolidation of short-term memory into long-term memory. Previous electrophysiological data concerning LTP in CA3 suggest that protein synthesis in that region might also be necessary for short-term mem...
Molecular correlates of cortical network modulation by long-term sensory experience in the adult rat barrel cortex [0.03%]
成人海马脑皮层长期感觉经验的分子相关因素
Astrid Vallès,Ivica Granic,Peter De Weerd et al.
Astrid Vallès et al.
Modulation of cortical network connectivity is crucial for an adaptive response to experience. In the rat barrel cortex, long-term sensory stimulation induces cortical network modifications and neuronal response changes of which the molecul...
Safety signals as instrumental reinforcers during free-operant avoidance [0.03%]
自由作 operand 回避期间的安全信号作为工具强化因素
Anushka B P Fernando,Gonzalo P Urcelay,Adam C Mar et al.
Anushka B P Fernando et al.
Safety signals provide "relief" through predicting the absence of an aversive event. At issue is whether these signals also act as instrumental reinforcers. Four experiments were conducted using a free-operant lever-press avoidance paradigm...
Protein degradation by ubiquitin-proteasome system in formation and labilization of contextual conditioning memory [0.03%]
泛素-蛋白酶体系统介导的蛋白质降解在情境条件性记忆的形成和消退中的作用
María Sol Fustiñana,Verónica de la Fuente,Noel Federman et al.
María Sol Fustiñana et al.
The ubiquitin-proteasome system (UPS) of protein degradation has been evaluated in different forms of neural plasticity and memory. The role of UPS in such processes is controversial. Several results support the idea that the activation of ...
Marc T J Exton-McGuinness,Rosemary C Patton,Lawrence B Sacco et al.
Marc T J Exton-McGuinness et al.
Once consolidated, memories are dynamic entities that go through phases of instability in order to be updated with new information, via a process of reconsolidation. The phenomenon of reconsolidation has been demonstrated in a wide variety ...