Time course of the rabbit's conditioned nictitating membrane movements during acquisition, extinction, and reacquisition [0.03%]
兔条件眨眼反应获得、消退和再获得的时间过程研究
E James Kehoe,Elliot A Ludvig,Richard S Sutton
E James Kehoe
The present experiment tested whether or not the time course of a conditioned eyeblink response, particularly its duration, would expand and contract, as the magnitude of the conditioned response (CR) changed massively during acquisition, e...
Prediction error demarcates the transition from retrieval, to reconsolidation, to new learning [0.03%]
预测误差划分了从提取到重新巩固再到新学习的过渡阶段
Dieuwke Sevenster,Tom Beckers,Merel Kindt
Dieuwke Sevenster
Although disrupting reconsolidation is promising in targeting emotional memories, the conditions under which memory becomes labile are still unclear. The current study showed that post-retrieval changes in expectancy as an index for predict...
Visualization of plasticity in fear-evoked calcium signals in midbrain dopamine neurons [0.03%]
脑干多巴胺神经元中由恐惧诱发的钙信号可塑性的可视化研究
Bryan B Gore,Marta E Soden,Larry S Zweifel
Bryan B Gore
Dopamine is broadly implicated in fear-related processes, yet we know very little about signaling dynamics in these neurons during active fear conditioning. We describe the direct imaging of calcium signals of dopamine neurons during Pavlov...
Epigenetic contributions to cognitive aging: disentangling mindspan and lifespan [0.03%]
表观遗传学对认知衰老的贡献：解开心智寿命和寿命的关系
Amy M Spiegel,Angila S Sewal,Peter R Rapp
Amy M Spiegel
Epigenetic modifications of chromatin structure provide a mechanistic interface for gene-environment interactions that impact the individualization of health trajectories across the lifespan. A growing body of research indicates that dysfun...
A role for histone deacetylases in the cellular and behavioral mechanisms underlying learning and memory [0.03%]
组蛋白去乙酰酶在学习和记忆的细胞及行为机制中的作用
Melissa Mahgoub,Lisa M Monteggia
Melissa Mahgoub
Histone deacetylases (HDACs) are a family of chromatin remodeling enzymes that restrict access of transcription factors to the DNA, thereby repressing gene expression. In contrast, histone acetyltransferases (HATs) relax the chromatin struc...
The effect of insulin and insulin-like growth factors on hippocampus- and amygdala-dependent long-term memory formation [0.03%]
胰岛素和类似物对海马依赖性和杏仁核依赖性长期记忆形成的影响
Sarah A Stern,Dillon Y Chen,Cristina M Alberini
Sarah A Stern
Recent work has reported that the insulin-like growth factor 2 (IGF2) promotes memory enhancement. Furthermore, impaired insulin or IGF1 functions have been suggested to play a role in the pathogenesis of neurodegeneration and cognitive imp...
Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us [0.03%]
脆性X综合征智能低下蛋白缺乏相关的学习和行为障碍：fly模型和小鼠模型的启示
Ana Rita Santos,Alexandros K Kanellopoulos,Claudia Bagni
Ana Rita Santos
The Fragile X syndrome (FXS) is the most frequent form of inherited mental disability and is considered a monogenic cause of autism spectrum disorder. FXS is caused by a triplet expansion that inhibits the expression of the FMR1 gene. The g...
Anne K Hart,John H Byrne
Anne K Hart
Molecular mechanisms underlying formation of long-term reward memories and extinction memories in the honeybee (Apis mellifera) [0.03%]
关于蜜蜂(Apis mellifera)长期回报记忆及消退记忆形成的分子机制
Dorothea Eisenhardt
Dorothea Eisenhardt
The honeybee (Apis mellifera) has long served as an invertebrate model organism for reward learning and memory research. Its capacity for learning and memory formation is rooted in the ecological need to efficiently collect nectar and polle...
Jeffrey P Gavornik,Mark F Bear
Jeffrey P Gavornik
It has been more than 50 years since the first description of ocular dominance plasticity--the profound modification of primary visual cortex (V1) following temporary monocular deprivation. This discovery immediately attracted the intense i...