Enhanced AMPA receptor function promotes cerebellar long-term depression rather than potentiation [0.03%]
增强型AMPA受体功能可促进小脑长期抑制而不是突触增强
Boeke J van Beugen,Xin Qiao,Dana H Simmons et al.
Boeke J van Beugen et al.
Ampakines are allosteric modulators of AMPA receptors that facilitate hippocampal long-term potentiation (LTP) and learning, and have been considered for the treatment of cognition and memory deficits. Here, we show that the ampakine CX546 ...
α-Band oscillations in intracellular membrane potentials of dentate gyrus neurons in awake rodents [0.03%]
清醒啮齿动物海马dentate gyrus神经元细胞内膜电位的α频段振荡现象
Ross W Anderson,Ben W Strowbridge
Ross W Anderson
The hippocampus and dentate gyrus play critical roles in processing declarative memories and spatial information. Dentate granule cells, the first relay in the trisynaptic circuit through the hippocampus, exhibit low spontaneous firing rate...
Differential involvement of amygdala and cortical NMDA receptors activation upon encoding in odor fear memory [0.03%]
关于杏仁体和皮层N-甲基-D天冬氨酸受体在气味恐惧记忆编码中的不同作用
Chloé Hegoburu,Sandrine Parrot,Guillaume Ferreira et al.
Chloé Hegoburu et al.
Although the basolateral amygdala (BLA) plays a crucial role for the acquisition of fear memories, sensory cortices are involved in their long-term storage in rats. However, the time course of their respective involvement has received littl...
Pharmacological enhancement of mGluR5 facilitates contextual fear memory extinction [0.03%]
药理增强mGluR5促进情境恐惧记忆的消退
Ferzin Sethna,Hongbing Wang
Ferzin Sethna
Behavioral exposure therapy, which involves extinction of the previously acquired fear, has been used to treat anxiety-related symptoms such as post-traumatic stress disorder. It has been hypothesized that proextinction pharmacotherapeutics...
Amnesia of inhibitory avoidance by scopolamine is overcome by previous open-field exposure [0.03%]
先前的开放场地暴露能克服东莨菪碱引起的抑制性回避遗忘
Natalia C Colettis,Marina Snitcofsky,Edgar E Kornisiuk et al.
Natalia C Colettis et al.
The muscarinic cholinergic receptor (MAChR) blockade with scopolamine either extended or restricted to the hippocampus, before or after training in inhibitory avoidance (IA) caused anterograde or retrograde amnesia, respectively, in the rat...
Optogenetic activation of presynaptic inputs in lateral amygdala forms associative fear memory [0.03%]
侧杏仁体外侧核光遗传学激活前突触输入形成条件恐惧记忆
Jeong-Tae Kwon,Ryuichi Nakajima,Hyung-Su Kim et al.
Jeong-Tae Kwon et al.
In Pavlovian fear conditioning, the lateral amygdala (LA) has been highlighted as a key brain site for association between sensory cues and aversive stimuli. However, learning-related changes are also found in upstream sensory regions such ...
Long-term potentiation can be induced in the CA1 region of hippocampus in the absence of αCaMKII T286-autophosphorylation [0.03%]
αCaMKII 的T286自磷酸化并非诱导海马CA1区长期增益的必要条件
Agnès Villers,Karl Peter Giese,Laurence Ris
Agnès Villers
α-calcium/calmodulin-dependent protein kinase (αCaMKII) T286-autophosphorylation provides a short-term molecular memory that was thought to be required for LTP and for learning and memory. However, it has been shown that learning can occu...
Appetitive cue-evoked ERK signaling in the nucleus accumbens requires NMDA and D1 dopamine receptor activation and regulates CREB phosphorylation [0.03%]
阿片类药物渴求的条件作用需要伏核中的N-甲基-D天冬氨酸受体和多巴胺D1样受体的相互作用并调节细胞因子信号转导及转录激活因子介导的CREB磷酸化反应
Erin K Z Kirschmann,Jocelyn C Mauna,Cory M Willis et al.
Erin K Z Kirschmann et al.
Conditioned stimuli (CS) can modulate reward-seeking behavior. This modulatory effect can be maladaptive and has been implicated in excessive reward seeking and relapse to drug addiction. We previously demonstrated that exposure to an appet...
Appetitive context conditioning proactively, but transiently, interferes with expression of counterconditioned context fear [0.03%]
食欲性情境条件作用会主动但短暂地干扰逆条件作用的情境恐惧的表达
Nathan M Holmes,R Frederick Westbrook
Nathan M Holmes
Four experiments used rats to study appetitive-aversive transfer. Rats trained to eat a palatable food in a distinctive context and shocked in that context ate and did not freeze when tested 1 d later but froze and did not eat when tested 1...
Andrew W Stamm,Nam D Nguyen,Benjamin J Seicol et al.
Andrew W Stamm et al.
Post-learning sleep is beneficial for human memory. However, it may be that not all memories benefit equally from sleep. Here, we manipulated a spatial learning task using monetary reward and performance feedback, asking whether enhancing t...