Janine L Kwapis,Timothy J Jarome,Fred J Helmstetter
Janine L Kwapis
The extinction of delay fear conditioning relies on a neural circuit that has received much attention and is relatively well defined. Whether this established circuit also supports the extinction of more complex associations, however, is un...
Potent attenuation of context fear by extinction training contiguous with acquisition [0.03%]
与获得性训练连续的消退训练强烈抑制上下文恐惧
Brian E Bernier,Anthony F Lacagnina,Michael R Drew
Brian E Bernier
Studies on the behavioral mechanisms underlying contextual fear conditioning (CFC) have demonstrated the importance of preshock context exposure in the formation of aversive context memories. However, there has been comparatively little inv...
Ciara M Greene,Kleio Vidaki,David Soto
Ciara M Greene
Familiar stimuli are typically accompanied by decreases in neural response relative to the presentation of novel items, but these studies often include explicit instructions to discriminate old and new items; this creates difficulties in pa...
Transcriptional analysis of a whole-body form of long-term habituation in Aplysia californica [0.03%]
加州海兔全身长期习惯化行为的转录组分析研究
Geraldine Holmes,Samantha Herdegen,Jonathan Schuon et al.
Geraldine Holmes et al.
Habituation is the simplest form of learning, but we know little about the transcriptional mechanisms that encode long-term habituation memory. A key obstacle is that habituation is relatively stimulus-specific and is thus encoded in small ...
Hippocampus contributes to the maintenance but not the quality of visual information over time [0.03%]
海马体有助于视觉信息的维持但不影响其质量
David E Warren,Melissa C Duff,Neal J Cohen et al.
David E Warren et al.
The hippocampus has recently been implicated in the brief representation of visual information, but its specific role is not well understood. We investigated this role using a paradigm that distinguishes quantity and quality of visual memor...
Immediate-early gene transcriptional activation in hippocampus CA1 and CA3 does not accurately reflect rapid, pattern completion-based retrieval of context memory [0.03%]
海马CA1和CA3区的即时基因转录激活不能准确反映情境记忆的快速表征回忆过程中的模式补充机制
Aleksandr Pevzner,John F Guzowski
Aleksandr Pevzner
No studies to date have examined whether immediate-early gene (IEG) activation is driven by context memory recall. To address this question, we utilized the context preexposure facilitation effect (CPFE) paradigm. In CPFE, animals acquire c...
Extinction, reacquisition, and rapid forgetting of eyeblink conditioning in developing rats [0.03%]
发育期大鼠中眨眼条件反射的消失、重建和快速遗忘现象
Kevin L Brown,John H Freeman
Kevin L Brown
Eyeblink conditioning is a well-established model for studying the developmental neurobiology of associative learning and memory. However, age differences in extinction and subsequent reacquisition have yet to be studied using this model. T...
Behavioral flexibility and response selection are impaired after limited exposure to oxycodone [0.03%]
短时间接触羟考酮会损害行为灵活性和反应选择性
Katharine M Seip-Cammack,Matthew L Shapiro
Katharine M Seip-Cammack
Behavioral flexibility allows individuals to adapt to situations in which rewards and goals change. Potentially addictive drugs may impair flexible decision-making by altering brain mechanisms that compute reward expectancies, thereby facil...
Duration of the unconditioned stimulus in appetitive conditioning of honeybees differentially impacts learning, long-term memory strength, and the underlying protein synthesis [0.03%]
未条件刺激的持续时间通过差分蜂 Appetitive 条件作用影响学习、长期记忆强度及其基础蛋白质合成的不同点
Kathrin Marter,M Katharina Grauel,Carmen Lewa et al.
Kathrin Marter et al.
This study examines the role of stimulus duration in learning and memory formation of honeybees (Apis mellifera). In classical appetitive conditioning honeybees learn the association between an initially neutral, conditioned stimulus (CS) a...
Jason R Fuchs,Gain M Robinson,Aaron M Dean et al.
Jason R Fuchs et al.
We have previously shown that intracerebellar infusion of the neuropeptide secretin enhances the acquisition phase of eyeblink conditioning (EBC). Here, we sought to test whether endogenous secretin also regulates EBC and to test whether th...