Modeling neurodegenerative and neurodevelopmental disorders in the Drosophila mushroom body [0.03%]
模式生物蘑菇体中神经退行性疾病和神经发育障碍的建模研究
Aaron Stahl,Seth M Tomchik
Aaron Stahl
The common fruit fly Drosophila melanogaster provides a powerful platform to investigate the genetic, molecular, cellular, and neural circuit mechanisms of behavior. Research in this model system has shed light on multiple aspects of brain ...
The caloric value of food intake structurally adjusts a neuronal mushroom body circuit mediating olfactory learning in Drosophila [0.03%]
卡路里值通过结构上调节神经蘑菇体回路来调控果蝇的嗅觉学习效应
Büşra Çoban,Haiko Poppinga,El Yazid Rachad et al.
Büşra Çoban et al.
Associative learning enables the adaptive adjustment of behavioral decisions based on acquired, predicted outcomes. The valence of what is learned is influenced not only by the learned stimuli and their temporal relations, but also by prior...
Reinforcement expectation in the honeybee (Apis mellifera): Can downshifts in reinforcement show conditioned inhibition? [0.03%]
蜜蜂的强化预期（Apis mellifera）：强化下降能表现出条件抑制作用吗？
Shawn Mahoney,Jay Hosler,Brian H Smith
Shawn Mahoney
When animals learn the association of a conditioned stimulus (CS) with an unconditioned stimulus (US), later presentation of the CS invokes a representation of the US. When the expected US fails to occur, theoretical accounts predict that c...
What do the mushroom bodies do for the insect brain? Twenty-five years of progress [0.03%]
蘑菇体让昆虫脑干什么？二十年研究进展回顾
André Fiala,Karla R Kaun
André Fiala
In 1998, a special edition of Learning & Memory was published with a discrete focus of synthesizing the state of the field to provide an overview of the function of the insect mushroom body. While molecular neuroscience and optical imaging ...
Sensory encoding and memory in the mushroom body: signals, noise, and variability [0.03%]
蕈状体中的感觉编码和记忆：信号、噪声与变异
Moshe Parnas,Julia E Manoim,Andrew C Lin
Moshe Parnas
To survive in changing environments, animals need to learn to associate specific sensory stimuli with positive or negative valence. How do they form stimulus-specific memories to distinguish between positively/negatively associated stimuli ...
Oriane Turrel,Lili Gao,Stephan J Sigrist
Oriane Turrel
The intricate molecular and structural sequences guiding the formation and consolidation of memories within neuronal circuits remain largely elusive. In this study, we investigate the roles of two pivotal presynaptic regulators, the small G...
Ivy Chi Wai Chan,Nannan Chen,John Hernandez et al.
Ivy Chi Wai Chan et al.
How does the brain translate sensory information into complex behaviors? With relatively small neuronal numbers, readable behavioral outputs, and an unparalleled genetic toolkit, the Drosophila mushroom body (MB) offers an excellent model t...
Roles of feedback and feed-forward networks of dopamine subsystems: insights from Drosophila studies [0.03%]
多巴胺子系统反馈和前馈网络的作用：来自果蝇研究的启示
Andrew M Davidson,Toshihide Hige
Andrew M Davidson
Across animal species, dopamine-operated memory systems comprise anatomically segregated, functionally diverse subsystems. Although individual subsystems could operate independently to support distinct types of memory, the logical interplay...
Cognitive limits of larval Drosophila: testing for conditioned inhibition, sensory preconditioning, and second-order conditioning [0.03%]
果蝇幼虫的认知极限：检测条件性抑制、感觉预处理和二级条件反射
Edanur Sen,Amira El-Keredy,Nina Jacob et al.
Edanur Sen et al.
Drosophila larvae are an established model system for studying the mechanisms of innate and simple forms of learned behavior. They have about 10 times fewer neurons than adult flies, and it was the low total number of their neurons that all...
Mareike Selcho
Mareike Selcho
Octopamine, the functional analog of noradrenaline, modulates many different behaviors and physiological processes in invertebrates. In the central nervous system, a few octopaminergic neurons project throughout the brain and innervate almo...