Dysregulating mTORC1-4E-BP2 signaling in GABAergic interneurons impairs hippocampus-dependent learning and memory [0.03%]
GABA能中间神经元中mTORC1-4E-BP2信号传导紊乱损害海马依赖性学习和记忆功能
Ziying Huang,Shane Wiebe,Anmol Nagpal et al.
Ziying Huang et al.
Memory formation is contingent on molecular and structural changes in neurons in response to learning stimuli-a process known as neuronal plasticity. The initiation step of mRNA translation is a gatekeeper of long-term memory by controlling...
Reactivation-dependent transfer of fear memory between contexts requires M1 muscarinic receptor stimulation in dorsal hippocampus of male rats [0.03%]
雄性大鼠背侧海马M₁胆碱能受体参与恐惧记忆情境间转移的再激活依赖性作用
Karim H Abouelnaga,Andrew E Huff,Kristen H Jardine et al.
Karim H Abouelnaga et al.
Memory updating is essential for integrating new information into existing representations. However, this process could become maladaptive in conditions like post-traumatic stress disorder (PTSD), when fear memories generalize to neutral co...
Domain-selective and sex-dependent regulation of learning and memory in mice by GIRK channel activity in CA1 pyramidal neurons of the dorsal hippocampus [0.03%]
GIRK通道在海马CA1锥体神经元中的性别依赖性和域选择性调节小鼠的学习和记忆能力
Haichang Luo,McKinzie Frederick,Ezequiel Marron Fernandez de Velasco et al.
Haichang Luo et al.
G protein-gated inwardly rectifying K+ (GIRK) channels mediate the postsynaptic inhibitory effect of many neurotransmitters in the hippocampus and are implicated in neurological disorders characterized by cognitive deficits. Here, we show t...
Sex and the facilitation of cued fear by prior contextual fear conditioning in rats [0.03%]
大鼠性经历对其后应激反应的影响
Katherine Vazquez,Kehinde E Cole,Ryan G Parsons
Katherine Vazquez
Previous studies have shown that the formation of new memories can be influenced by prior experience. This includes work using Pavlovian fear conditioning in rodents that has shown that an initial fear conditioning experience can become ass...
High stakes slow responding, but do not help overcome Pavlovian biases in humans [0.03%]
高风险下人类反应缓慢，但仍无法克服巴甫洛夫偏见
Johannes Algermissen,Hanneke E M den Ouden
Johannes Algermissen
"Pavlovian" or "motivational" biases are the phenomenon that the valence of prospective outcomes modulates action invigoration: the prospect of reward invigorates actions, while the prospect of punishment suppresses actions. Effects of the ...
Decoding Arc transcription: a live-cell study of stimulation patterns and transcriptional output [0.03%]
活细胞刺激模式和转录组输出的解码研究
Dong Wook Kim,Hyungseok C Moon,Byung Hun Lee et al.
Dong Wook Kim et al.
Activity-regulated cytoskeleton-associated protein (Arc) plays a crucial role in synaptic plasticity, a process integral to learning and memory. Arc transcription is induced within a few minutes of stimulation, making it a useful marker for...
Courteney T L Fisher,Gonzalo P Urcelay
Courteney T L Fisher
Safety signals reinforce instrumental avoidance behavior in nonhuman animals. However, there are no conclusive demonstrations of this phenomenon in humans. Using human participants in an avoidance task, Experiments 1-3 and 5 were conducted ...
Connecting self-report and instrumental behavior during incubation of food craving in humans [0.03%]
人类在食物渴望期间连接自我报告和工具行为的脑机制研究
Nicholas A Ruiz,Devlin Eckardt,Lisa A Briand et al.
Nicholas A Ruiz et al.
Incubation of craving is a phenomenon describing the intensification of craving for a reward over extended periods of abstinence from reinforcement. Animal models use instrumental markers of craving to reward cues to examine incubation, whi...
Network motifs exhibiting a differential response to spaced and massed inputs [0.03%]
表现间隔输入和群集输入不同反应的网络动机模型
Ashley Sreejan,Priyanka Saxena,Chetan J Gadgil
Ashley Sreejan
One characteristic of long-term memory is the existence of an inverted U-shaped response to increasing intervals between training sessions, and consequently, an optimal spacing that maximizes memory formation. Current models of this spacing...
Flexible decision-making is related to strategy learning, vicarious trial and error, and medial prefrontal rhythms during spatial set-shifting [0.03%]
灵活的决策与空间任务转换过程中的策略学习、间接尝试和错误以及前额叶脑电节律有关
Jesse T Miles,Ginger L Mullins,Sheri J Y Mizumori
Jesse T Miles
Flexible decision-making requires a balance between exploring features of an environment and exploiting prior knowledge. Behavioral flexibility is typically measured by how long it takes subjects to consistently make accurate choices after ...