High and low current perceived stress associated with enhanced emotional mnemonic discrimination [0.03%]
高压力和低压力下的感知压力与情感记忆辨别的增强相关性研究
Rishi Vas,Taylor Phillips,Lorena A Ferguson et al.
Rishi Vas et al.
Stress can have profound impacts on memory. However, the directionality of stress effects on memory varies widely across studies, some showing enhancement while others showing impairment. This variability has been attributed to the Yerkes-D...
Emotional intensity produces a linear relationship on conditioned learning but an inverted U-shaped effect on episodic memory [0.03%]
情绪强度在条件学习中产生线性关系，但在情景记忆中呈现倒U形效应
Lingwei Ouyang,Joseph E Dunsmoor
Lingwei Ouyang
Emotional intensity can produce both optimal and suboptimal effects on learning and memory. While emotional events tend to be better remembered, memory performance can follow an inverted U-shaped curve with increasing intensity. The strengt...
Social and nonsocial environmental loss have differential effects on ventral hippocampus-dependent behavior and inhibitory synaptic markers in adult male mice [0.03%]
社会性和非社会性环境丧失对成年雄性小鼠腹侧海马依赖的行为和抑制性突触标志物具有不同的影响
Isha R Gore,Casey J Brown,Renée C Waters et al.
Isha R Gore et al.
In humans, psychological loss, whether social or nonsocial, can lead to clinical depression, anxiety disorders, and social memory impairments. Researchers have modeled combined social and nonsocial loss in rodents by transitioning them from...
Lateral entorhinal cortex neurons that project to nucleus accumbens mediate contextual associative memory [0.03%]
侧嗅皮质至伏隔核投射神经元参与情境联想记忆编码
Hayley M Kuhn,Luis Colon Serrano,Grace A Stys et al.
Hayley M Kuhn et al.
The lateral entorhinal cortex (LEC) contains glutamatergic projections that innervate the nucleus accumbens (NAc) and may be involved in the encoding of contextual associations with both positive and negative valences, such as those encount...
Hillary Schwarb,Michael Dulas,Neal Cohen
Hillary Schwarb
Binding of arbitrary information into distinct memory representations that can be used to guide behavior is a hallmark of relational memory. What is and is not bound into a memory representation and how those things influence the organizati...
Dysregulating mTORC1-4E-BP2 signaling in GABAergic interneurons impairs hippocampus-dependent learning and memory [0.03%]
GABA能中间神经元中mTORC1-4E-BP2信号传导紊乱损害海马依赖性学习和记忆功能
Ziying Huang,Shane Wiebe,Anmol Nagpal et al.
Ziying Huang et al.
Memory formation is contingent on molecular and structural changes in neurons in response to learning stimuli-a process known as neuronal plasticity. The initiation step of mRNA translation is a gatekeeper of long-term memory by controlling...
Reactivation-dependent transfer of fear memory between contexts requires M1 muscarinic receptor stimulation in dorsal hippocampus of male rats [0.03%]
雄性大鼠背侧海马M₁胆碱能受体参与恐惧记忆情境间转移的再激活依赖性作用
Karim H Abouelnaga,Andrew E Huff,Kristen H Jardine et al.
Karim H Abouelnaga et al.
Memory updating is essential for integrating new information into existing representations. However, this process could become maladaptive in conditions like post-traumatic stress disorder (PTSD), when fear memories generalize to neutral co...
Domain-selective and sex-dependent regulation of learning and memory in mice by GIRK channel activity in CA1 pyramidal neurons of the dorsal hippocampus [0.03%]
GIRK通道在海马CA1锥体神经元中的性别依赖性和域选择性调节小鼠的学习和记忆能力
Haichang Luo,McKinzie Frederick,Ezequiel Marron Fernandez de Velasco et al.
Haichang Luo et al.
G protein-gated inwardly rectifying K+ (GIRK) channels mediate the postsynaptic inhibitory effect of many neurotransmitters in the hippocampus and are implicated in neurological disorders characterized by cognitive deficits. Here, we show t...
Sex and the facilitation of cued fear by prior contextual fear conditioning in rats [0.03%]
大鼠性经历对其后应激反应的影响
Katherine Vazquez,Kehinde E Cole,Ryan G Parsons
Katherine Vazquez
Previous studies have shown that the formation of new memories can be influenced by prior experience. This includes work using Pavlovian fear conditioning in rodents that has shown that an initial fear conditioning experience can become ass...
High stakes slow responding, but do not help overcome Pavlovian biases in humans [0.03%]
高风险下人类反应缓慢，但仍无法克服巴甫洛夫偏见
Johannes Algermissen,Hanneke E M den Ouden
Johannes Algermissen
"Pavlovian" or "motivational" biases are the phenomenon that the valence of prospective outcomes modulates action invigoration: the prospect of reward invigorates actions, while the prospect of punishment suppresses actions. Effects of the ...