Reward responsiveness (BAS) facilitates contingency awareness in appetitive conditioning [0.03%]
奖励敏感性（BAS）在诱发条件反射中促进连锁反应意识
Johannes B Finke,Tim Klucken
Johannes B Finke
Individual differences in reinforcement sensitivity may shape associative learning processes. We investigated how behavioral inhibition and activation systems (BIS/BAS), that is, variation in avoidance versus approach tendencies, modulate a...
Multiple context discrimination in adult rats: sex variability and dynamics of time-dependent generalization of an aversive memory [0.03%]
成年大鼠多重情境辨别中的性别差异及厌恶记忆的时间依赖性泛化的动态变化
Fernanda Nogueira Lotz,Kétlyn Talise Knak Guerra,Ana Paula Crestani et al.
Fernanda Nogueira Lotz et al.
Memory generalization involves the transfer of conditioned fear responses to novel contexts, a phenomenon observed in systems consolidation, whereby a time-dependent reduction in discrimination precision occurs due to the reorganization of ...
Robust renewal after extinction of remotely acquired Pavlovian conditioning [0.03%]
远距离获得的经典条件作用消退后的稳健更新
Joseph W Charles,Samantha K Moriarty,Danielle I Fournier et al.
Joseph W Charles et al.
Extinguished responses are prone to renew outside the context where extinction occurred. Two experiments compared extinction and renewal following either a 1 day conditioning-to-extinction interval or a 27 day interval. Rats received tone-s...
Individual contribution of PDE4B and PDE4D subfamilies to the prevention of object location memory impairments induced by sleep deprivation [0.03%]
PDE4B和PDE4D亚家族分别对于睡眠剥夺引起的物体位置记忆缺损的预防作用
Hongyu Zhao,Arjan Blokland,Jos Prickaerts et al.
Hongyu Zhao et al.
Insufficient sleep compromises the cAMP signaling pathway in the hippocampus, negatively impacting hippocampus-dependent memory. In the current study, we explored whether selective PDE4B or selective PDE4D inhibition can improve hippocampus...
Weizhen Xie,Susan G Wardle,Jenna Langbein et al.
Weizhen Xie et al.
Classic models propose that forming lasting visual memories involves coordinated interactions between visually selective neocortical structures and the hippocampus during memory consolidation. However, the precise role of visually selective...
Using a socially enriched environment test to evaluate the effects of different therapeutic approaches on social behavior in a mouse model of social anxiety disorder [0.03%]
采用社会强化环境测试评估不同治疗方案对社交焦虑障碍小鼠模型社交行为的影响效果
Zineb Boudjafad,Chaima Ihsan,Ilias Chaibi et al.
Zineb Boudjafad et al.
Social anxiety disorder (SAD) stands as a prevalent psychiatric condition characterized by the apprehension of scrutiny and embarrassment in social settings, leading to anxiety symptoms, avoidance behaviors, and impaired social and occupati...
Medial septal theta stimulation enhances spatial working memory performance in rats [0.03%]
中隔theta刺激增强大鼠空间工作记忆性能
Zachary M Gemzik,Amy L Griffin
Zachary M Gemzik
Spatial working memory (SWM) relies on the integrity of the medial septum area (MSA) and its ability to drive theta (4-12 Hz) oscillations in the hippocampus. This study tested the hypothesis that optogenetic theta stimulation of the MSA wo...
Decreases in H2A monoubiquitination in the amygdala constrain fear memory formation [0.03%]
杏仁核中H2A单泛素化程度的下降限制了恐惧记忆的形成
Yeeun Bae,Harshini Venkat,Natalie Preveza et al.
Yeeun Bae et al.
Evidence suggests a role for monoubiquitination of histone H2B, a regulator of increased gene transcription, in memory formation. However, whether monoubiquitination of histone H2A (H2Aubi), a transcriptional repressor, is involved in memor...
Behavioral microanalyses refine sign-tracking characterization and uncover different response dynamics during omission and extinction learning [0.03%]
行为微分析精简信号追踪特征并在省略和消退学习期间揭示不同的反应动态特性
Erica S Townsend,Kyle S Smith
Erica S Townsend
Sign-tracking, a conditioned response in which animals engage with reward-predictive cues, is a powerful behavioral tool for assessing Pavlovian motivation. In rodents, it is most frequently studied via automatic readouts, such as deflectio...
Overexpression of the Apoe gene in the frontal cortex of mice causes sex-dependent changes in learning, attention, and anxiety-like behavior [0.03%]
小鼠前额皮质中Apoe基因的过表达导致学习、注意力和类似焦虑行为的性别依赖性改变
Lizbeth Ramos,Abigail E Harr,Finian L Zakas et al.
Lizbeth Ramos et al.
Apolipoprotein E (ApoE) is a protein that is important for lipid storage, transport, and metabolism. APOE gene variants are associated with Alzheimer's disease, as well as attentional function in healthy humans. Previous research has shown ...