Using a socially enriched environment test to evaluate the effects of different therapeutic approaches on social behavior in a mouse model of social anxiety disorder [0.03%]
采用社会强化环境测试评估不同治疗方案对社交焦虑障碍小鼠模型社交行为的影响效果
Zineb Boudjafad,Chaima Ihsan,Ilias Chaibi et al.
Zineb Boudjafad et al.
Social anxiety disorder (SAD) stands as a prevalent psychiatric condition characterized by the apprehension of scrutiny and embarrassment in social settings, leading to anxiety symptoms, avoidance behaviors, and impaired social and occupati...
Medial septal theta stimulation enhances spatial working memory performance in rats [0.03%]
中隔theta刺激增强大鼠空间工作记忆性能
Zachary M Gemzik,Amy L Griffin
Zachary M Gemzik
Spatial working memory (SWM) relies on the integrity of the medial septum area (MSA) and its ability to drive theta (4-12 Hz) oscillations in the hippocampus. This study tested the hypothesis that optogenetic theta stimulation of the MSA wo...
Decreases in H2A monoubiquitination in the amygdala constrain fear memory formation [0.03%]
杏仁核中H2A单泛素化程度的下降限制了恐惧记忆的形成
Yeeun Bae,Harshini Venkat,Natalie Preveza et al.
Yeeun Bae et al.
Evidence suggests a role for monoubiquitination of histone H2B, a regulator of increased gene transcription, in memory formation. However, whether monoubiquitination of histone H2A (H2Aubi), a transcriptional repressor, is involved in memor...
Behavioral microanalyses refine sign-tracking characterization and uncover different response dynamics during omission and extinction learning [0.03%]
行为微分析精简信号追踪特征并在省略和消退学习期间揭示不同的反应动态特性
Erica S Townsend,Kyle S Smith
Erica S Townsend
Sign-tracking, a conditioned response in which animals engage with reward-predictive cues, is a powerful behavioral tool for assessing Pavlovian motivation. In rodents, it is most frequently studied via automatic readouts, such as deflectio...
Overexpression of the Apoe gene in the frontal cortex of mice causes sex-dependent changes in learning, attention, and anxiety-like behavior [0.03%]
小鼠前额皮质中Apoe基因的过表达导致学习、注意力和类似焦虑行为的性别依赖性改变
Lizbeth Ramos,Abigail E Harr,Finian L Zakas et al.
Lizbeth Ramos et al.
Apolipoprotein E (ApoE) is a protein that is important for lipid storage, transport, and metabolism. APOE gene variants are associated with Alzheimer's disease, as well as attentional function in healthy humans. Previous research has shown ...
Antonios Georgiou,Tankut Can,Mikhail Katkov et al.
Antonios Georgiou et al.
The statistical study of human memory requires large-scale experiments, involving many stimulus conditions and test subjects. While this approach has proven to be quite fruitful for meaningless material such as random lists of words, natura...
No effect of partial reinforcement on fear extinction learning and memory in C57BL/6J mice [0.03%]
部分强化对C57BL / 6J小鼠恐惧消退学习和记忆没有影响
Chi Jiun Su,Yuichi Fukunaga,Suzanne Penna et al.
Chi Jiun Su et al.
Partial reinforcement schedules, wherein a conditioned stimulus (CS) is intermittently paired with an unconditioned stimulus (US) during associative learning, have been widely studied and found to affect the extinction and recall of learned...
Goal orientation shifts attentional focus and impairs reward-motivated memory [0.03%]
目标导向转移注意力焦点并损害奖励动机记忆
Lena J Skalaban,Allison L Neeson,Troy M Houser et al.
Lena J Skalaban et al.
While motivation typically enhances memory, some studies show that, in certain contexts, motivation associated with rewards can impair memory. Goal states associated with motivation can impact attention, which in turn influences what inform...
Olivier T de Vries,Merel Kindt,Vanessa A van Ast
Olivier T de Vries
How does negative affect spread through existing memories? Whereas many studies have investigated generalization of learned threat responses across perceptual and semantic dimensions, little attention has been given to the possibility that ...
The influence of exposure to early-life adversity on agency-modulated reinforcement learning [0.03%]
早期生活压力暴露对自主调节强化学习的影响
Hayley M Dorfman,Bryan J W Dong,Katie A McLaughlin et al.
Hayley M Dorfman et al.
Agency beliefs influence how humans learn from different contexts and outcomes. Research demonstrates that stressors, such as exposure to early-life adversity (ELA), are associated with both agency beliefs and learning, but how these proces...