Longitudinal attentional engagement rescues mice from age-related cognitive declines and cognitive inflexibility [0.03%]
纵向注意力参与可使小鼠免受年龄相关的认知衰退和认知僵化的影响
Louis D Matzel,Kenneth R Light,Christopher Wass et al.
Louis D Matzel et al.
Learning, attentional, and perseverative deficits are characteristic of cognitive aging. In this study, genetically diverse CD-1 mice underwent longitudinal training in a task asserted to tax working memory capacity and its dependence on se...
Cellular site and molecular mode of synapsin action in associative learning [0.03%]
与联想学习相关的synapsin作用部位及分子机制研究
Birgit Michels,Yi-Chun Chen,Timo Saumweber et al.
Birgit Michels et al.
Synapsin is an evolutionarily conserved, presynaptic vesicular phosphoprotein. Here, we ask where and how synapsin functions in associative behavioral plasticity. Upon loss or reduction of synapsin in a deletion mutant or via RNAi, respecti...
Different compartments of apical CA1 dendrites have different plasticity thresholds for expressing synaptic tagging and capture [0.03%]
顶树突不同部分的synaptic tagging and capture的表现阈值不同
Sreedharan Sajikumar,Martin Korte
Sreedharan Sajikumar
The consolidation process from short- to long-term memory depends on the type of stimulation received from a specific neuronal network and on the cooperativity and associativity between different synaptic inputs converging onto a specific n...
Staufen 2 regulates mGluR long-term depression and Map1b mRNA distribution in hippocampal neurons [0.03%]
Staufen2调控海马神经元的mGluR长期抑制和Map1b mRNA分布
Geneviève Lebeau,Linda C Miller,Maylis Tartas et al.
Geneviève Lebeau et al.
The two members of the Staufen family of RNA-binding proteins, Stau1 and Stau2, are present in distinct ribonucleoprotein complexes and associate with different mRNAs. Stau1 is required for protein synthesis-dependent long-term potentiation...
The neural cell adhesion molecule-derived peptide FGL facilitates long-term plasticity in the dentate gyrus in vivo [0.03%]
神经细胞粘附分子衍生肽FGL促进体内齿状回的长期可塑性
Glenn Dallérac,Meike Zerwas,Tatiana Novikova et al.
Glenn Dallérac et al.
The neural cell adhesion molecule (NCAM) is known to play a role in developmental and structural processes but also in synaptic plasticity and memory of the adult animal. Recently, FGL, a NCAM mimetic peptide that binds to the Fibroblast Gr...
The role of the hippocampus in retaining relational information across short delays: the importance of memory load [0.03%]
海马在短期延迟内保持关联信息的作用：记忆负荷的重要性
Annette Jeneson,Kristin N Mauldin,Ramona O Hopkins et al.
Annette Jeneson et al.
Patients with hippocampal damage are sometimes impaired at remembering information across delays as short as a few seconds. How are these impairments to be understood? One possibility is that retention of some kinds of information is critic...
Behavioral specifications of reward-associated long-term memory enhancement in humans [0.03%]
人类奖励相关长期记忆增强的行为规范
Bianca C Wittmann,Raymond J Dolan,Emrah Düzel
Bianca C Wittmann
Recent functional imaging studies link reward-related activation of the midbrain substantia nigra-ventral tegmental area (SN/VTA), the site of origin of ascending dopaminergic projections, with improved long-term episodic memory. Here, we i...
Systemic 5-bromo-2-deoxyuridine induces conditioned flavor aversion and c-Fos in the visceral neuraxis [0.03%]
系统性5-溴脱氧尿苷诱导味觉条件反射和c-Fos在内脏神经轴中表达
Adam Kimbrough,Bumsup Kwon,Lisa A Eckel et al.
Adam Kimbrough et al.
5-bromo-2-deoxyuridine (BrdU) is often used in studies of adult neurogenesis and olfactory learning, but it can also have toxic effects on highly proliferative tissue. We found that pairing Kool-Aid flavors with acute systemic injections of...
Odor preference learning and memory modify GluA1 phosphorylation and GluA1 distribution in the neonate rat olfactory bulb: testing the AMPA receptor hypothesis in an appetitive learning model [0.03%]
气味偏好学习记忆改变新生鼠嗅球中GluA1的磷酸化以及采用 appetitive 学习模型验证AMPA受体假说中的GluA1分布
Wen Cui,Andrea Darby-King,Matthew T Grimes et al.
Wen Cui et al.
An increase in synaptic AMPA receptors is hypothesized to mediate learning and memory. AMPA receptor increases have been reported in aversive learning models, although it is not clear if they are seen with memory maintenance. Here we examin...
The tail-elicited tail withdrawal reflex of Aplysia is mediated centrally at tail sensory-motor synapses and exhibits sensitization across multiple temporal domains [0.03%]
海兔尾部反射的中枢介导及多个时间域上的敏感性增强现象
Gary T Philips,Carolyn M Sherff,Steven A Menges et al.
Gary T Philips et al.
The defensive withdrawal reflexes of Aplysia californica have provided powerful behavioral systems for studying the cellular and molecular basis of memory formation. Among these reflexes the tail-elicited tail withdrawal reflex (T-TWR) has ...