Altered gene regulation and synaptic morphology in Drosophila learning and memory mutants [0.03%]
果蝇学习和记忆突变体中基因调控和突触形态的改变
Zhuo Guan,Lauren K Buhl,William G Quinn et al.
Zhuo Guan et al.
Genetic studies in Drosophila have revealed two separable long-term memory pathways defined as anesthesia-resistant memory (ARM) and long-lasting long-term memory (LLTM). ARM is disrupted in radish (rsh) mutants, whereas LLTM requires CREB-...
Deletion of the GluA1 AMPA receptor subunit impairs recency-dependent object recognition memory [0.03%]
删除AMPA受体GluA1亚基损害基于新近性的物体识别记忆
David J Sanderson,Emma Hindley,Emily Smeaton et al.
David J Sanderson et al.
Deletion of the GluA1 AMPA receptor subunit impairs short-term spatial recognition memory. It has been suggested that short-term recognition depends upon memory caused by the recent presentation of a stimulus that is independent of contextu...
Stimulus similarity and encoding time influence incidental recognition memory in adult monkeys with selective hippocampal lesions [0.03%]
刺激物的相似性和编码时间对选择性海马损伤的成年猴子意外识记的影响
Alyson Zeamer,Martine Meunier,Jocelyne Bachevalier
Alyson Zeamer
Recognition memory impairment after selective hippocampal lesions in monkeys is more profound when measured with visual paired-comparison (VPC) than with delayed nonmatching-to-sample (DNMS). To clarify this issue, we assessed the impact of...
Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairments [0.03%]
特异性删除p300条件的小鼠出现长期记忆障碍
Ana M M Oliveira,Marcel A Estévez,Joshua D Hawk et al.
Ana M M Oliveira et al.
Histone acetylation plays a critical role during long-term memory formation. Several studies have demonstrated that the histone acetyltransferase (HAT) CBP is required during long-term memory formation, but the involvement of other HAT prot...
Conceptual similarity promotes generalization of higher order fear learning [0.03%]
概念相似性促进高阶恐惧学习的泛化作用
Joseph E Dunsmoor,Allison J White,Kevin S LaBar
Joseph E Dunsmoor
We tested the hypothesis that conceptual similarity promotes generalization of conditioned fear. Using a sensory preconditioning procedure, three groups of subjects learned an association between two cues that were conceptually similar, unr...
Color modulates olfactory learning in honeybees by an occasion-setting mechanism [0.03%]
颜色通过条件设置机制调节蜜蜂的嗅觉学习能力
Theo Mota,Martin Giurfa,Jean-Christophe Sandoz
Theo Mota
A sophisticated form of nonelemental learning is provided by occasion setting. In this paradigm, animals learn to disambiguate an uncertain conditioned stimulus using alternative stimuli that do not enter into direct association with the un...
Requirement of dopamine signaling in the amygdala and striatum for learning and maintenance of a conditioned avoidance response [0.03%]
学习和保持条件性回避反应需要伏隔核和纹状体内的多巴胺信号传入
Martin Darvas,Jonathan P Fadok,Richard D Palmiter
Martin Darvas
Two-way active avoidance (2WAA) involves learning Pavlovian (association of a sound cue with a foot shock) and instrumental (shock avoidance) contingencies. To identify regions where dopamine (DA) is involved in mediating 2WAA, we restored ...
Repeatedly reactivated memories become more resistant to hippocampal damage [0.03%]
反复激活的记忆对海马损伤的抵抗能力更强
Hugo Lehmann,Kathryn C McNamara
Hugo Lehmann
We examined whether repeated reactivations of a context memory would prevent the typical amnesic effects of post-training damage to the hippocampus (HPC). Rats were given a single contextual fear-conditioning session followed by 10 reactiva...
Deletion of the GluA1 AMPA receptor subunit alters the expression of short-term memory [0.03%]
谷氨酸AMPA受体亚基GluA1的缺失影响短期记忆的表现形式
David J Sanderson,Rolf Sprengel,Peter H Seeburg et al.
David J Sanderson et al.
Deletion of the GluA1 AMPA receptor subunit selectively impairs short-term memory for spatial locations. We further investigated this deficit by examining memory for discrete nonspatial visual stimuli in an operant chamber. Unconditioned su...
Beta-adrenergic receptor activation rescues theta frequency stimulation-induced LTP deficits in mice expressing C-terminally truncated NMDA receptor GluN2A subunits [0.03%]
β肾上腺素受体激活可逆转C端截短的NMDAR GluN2A亚基小鼠中theta节律电刺激诱导的长时程 potentiation缺陷
Teena D Moody,Ayako M Watabe,Tim Indersmitten et al.
Teena D Moody et al.
Through protein interactions mediated by their cytoplasmic C termini the GluN2A and GluN2B subunits of NMDA receptors (NMDARs) have a key role in the formation of NMDAR signaling complexes at excitatory synapses. Although these signaling co...