Gizem Efe,Katherine Cunningham,Anil K Rustgi et al.
Gizem Efe et al.
The discovery of the p53 tumor suppressor protein raised fundamental questions about cell cycle regulation that have spanned several decades. TP53 mutations are found in most human cancers, most frequently as missense alterations in the DNA...
Susan J Baserga
Susan J Baserga
The nucleolus and Cajal bodies in the eukaryotic nucleus serve as dynamic hubs for an intricate network of protein-protein and protein-RNA interactions that drive the macromolecular assembly of large and small ribonucleoproteins. However, t...
Transcriptional derepression of negative regulators of MAP kinase supports maintenance of diapause ES cells in the pluripotent state [0.03%]
MAPK介导的转录共激活作用通过去抑制负调控因子来维持多能性地休胚胎干细胞状态
Tuo Zhang,Ryan J Marina,Rab Prinjha et al.
Tuo Zhang et al.
Nutrient deficiency during pregnancy in many animal species can induce embryonic diapause, a state characterized by systemic changes in biosynthetic processes that minimize reliance on external energy sources while ensuring survival. Remark...
Combinatorial use of VHL and KEAP1 PROTACs reveals unexpected synergy and hook effect relief [0.03%]
VHL和KEAP1 PROTACs的组合使用揭示了意外的协同作用和钩效应缓解
Sehbanul Islam,Haihong Jin,Dong Liu et al.
Sehbanul Islam et al.
Proteolysis-targeting chimeras (PROTACs) are bifunctional molecules bridging a protein with an E3 ubiquitin ligase, promoting its ubiquitylation and degradation. However, PROTACs are not without limitations, including suboptimal target degr...
PHA-4/FoxA controls the function of pharyngeal and extrapharyngeal enteric neurons in C. elegans [0.03%]
PHA-4/FoxA控制C. elegans咽部和非咽部肠神经元的功能
Zion Walker,Wen Xi Cao,Eduardo Leyva-Díaz et al.
Zion Walker et al.
FoxA transcription factors pattern gut tissue across animal phylogeny. Beyond their early patterning function, little is known about whether they control the terminal differentiation and/or function of the fully mature enteric nervous syste...
Corrigendum: A germline point mutation in the MYC-FBW7 phosphodegron initiates hematopoietic malignancies [0.03%]
端粒酶启动子点突变通过MYC-FBW7经典信号轴驱动血液系统恶性肿瘤发起的校正说明文：MYC-FBW7磷酸化靶向降解基序的生殖系点突变引发造血系统恶性肿瘤
Brian Freie,Patrick A Carroll,Barbara J Varnum-Finney et al.
Brian Freie et al.
Published Erratum
Genes & development. 2025 Dec 1;39(23-24):1509. DOI:10.1101/gad.353345.125 2025
Corrigendum: Sept4/ARTS is required for stem cell apoptosis and tumor suppression [0.03%]
秋水仙素4/ARTS对干细胞凋亡和肿瘤抑制的作用不容忽视的更正公告
María García-Fernández,Holger Kissel,Samara Brown et al.
María García-Fernández et al.
Published Erratum
Genes & development. 2025 Dec 1;39(23-24):1510. DOI:10.1101/gad.353378.125 2025
Gamete fusion triggers cytosolic functions and P-body recruitment of the RNA-binding protein Mei2 to drive fission yeast zygotic development [0.03%]
受精触发RNA结合蛋白Mei2的细胞质功能和P体募集以驱动裂殖酵母合子发育
Ayokunle Araoyinbo,Clàudia Salat-Canela,Aleksandar Vještica
Ayokunle Araoyinbo
Compartmentalized regulation of RNAs is emerging as a key driver of developmental transitions, with RNA-binding proteins performing specialized functions in different subcellular compartments. The RNA-binding protein Mei2, which arrests mit...
Ashley P Ng,Stephen L Nutt
Ashley P Ng
The production of B cells is essential for a functional immune system. This process relies on the coordinated activity of a handful of transcription factors that act in part by modifying the chromatin landscape of lymphoid progenitors to al...
Intrinsically disordered regions stimulate concentration of small nucleolar ribonucleoproteins and formation of Cajal bodies and nucleoli [0.03%]
内在无序区域可刺激小核仁RNA颗粒的浓缩及Cajal体和核仁的形成
Koceila Meznad,Manisha Deogharia,Ludivine Wacheul et al.
Koceila Meznad et al.
One of the densest compartments in the cell is the dense fibrillar component (DFC) of the nucleolus, consisting mainly of nascent ribosomal RNA (rRNA), small nucleolar ribonucleoproteins (snoRNPs), and their chaperone, Nopp140 (gene name NO...