mTOR inactivation governs adaptive survival to ribosome biogenesis deficiency [0.03%]
抑制mTOR可使核糖体生物合成缺陷适应性生存反应的产生
Wenjun Fan,Hester Liu,Liling Yang et al.
Wenjun Fan et al.
Ribosome biogenesis is a resource-consuming process that facilitates rapid growth and feeds uncontrolled, cancerous traits. Constraining ribosome biogenesis and protein translation has become a tenable therapeutic strategy for cancer. Yet, ...
Human PIF1 clears secondary DNA structures by coupled DNA unwinding and rewinding activities [0.03%]
人源PIF1通过偶联的DNA解旋和重绕活性清除二级DNA结构
Akshay Jayachandran,Martin Mütze,Kostiantyn Romaniuk et al.
Akshay Jayachandran et al.
PIF1 family helicases promote genome stability during DNA replication and repair, yet the biochemical activity of human PIF1 (hPIF1) remains poorly understood. Here, we directly compare full-length hPIF1 and budding yeast Pif1 (yPif1) and s...
A conserved Notch-Meis1-Pbx cascade specifies secretory progenitors into spatially diverse intestinal best4 + cells [0.03%]
一个保守的Notch-Meis1-Pbx级联反应确定了谱系限制性隐窝基底分泌前体细胞向空间多样性肠道最佳4+细胞的分化方向
Abhinav Sur,Ella X Segal,Michael P Nunneley et al.
Abhinav Sur et al.
best4 + cells are a recently described vertebrate intestinal epithelial cell type. best4 + cells are altered in inflammatory bowel disease and colorectal cancer, suggesting that stimulation of their homeostatic replenishment may have therap...
RBM39 modulates UPR signaling through alternative splicing of IRE1α/ ERN1 [0.03%]
RBM39通过IRE1α/ERN1的可变剪接调节UPR信号转导
Jeongjin J Kim,Amit K Behera,Arun Prasath Damodaran et al.
Jeongjin J Kim et al.
The unfolded protein response (UPR) preserves endoplasmic reticulum proteostasis through coordinated signaling pathways, including the IRE1α-XBP1 axis, which promotes adaptive transcriptional programs via noncanonical XBP1 mRNA splicing. H...
Nuclear type I myosins actively support nucleolar and nuclear structure and function [0.03%]
核型I肌球蛋白积极支持核仁和核的结构与功能
Audrey Yi Tyan Peng,Jianhui Li,Brian C Freeman
Audrey Yi Tyan Peng
A nucleus is a remarkably arranged organelle partitioned from the cytosol by a nuclear envelope to encapsulate a highly structured space including a well-organized genome and nucleolus. Despite the conservation, our understanding of the mol...
Neuronal expression of bromodomain proteins alters neuronal health and peripheral protein homeostasis to promote longevity [0.03%]
溴结构域蛋白质的神经元表达改变神经元健康和外周蛋白稳态以促进长寿
Naibedya Dutta,Daniel Hicks,Edgar Esparza et al.
Naibedya Dutta et al.
Longevity and stress resilience require precise coordination of gene expression programs across tissues. Here, we demonstrate that overexpression of the chromatin reader bet-1 specifically in neurons of Caenorhabditis elegans promotes organ...
Mitotic MAX bookmarking drives MYC-dependent hypertranscription at TBP-bound promoters [0.03%]
有MYC依赖性的TBP结合的启动子上的超转录由有丝分裂MAX染色质印记驱动
Inma Gonzalez,Lieng Taing,Almira Chervova et al.
Inma Gonzalez et al.
Faithful genome reactivation after mitosis is essential for cell identity, yet the mechanisms driving global postmitotic transcription remain unclear. Here, we show that the MYC oncogene and its obligate partner MAX drive a postmitotic hype...
Lysosomal metabolism in pancreatic cancer and its crosstalk with host physiology [0.03%]
胰腺癌的溶酶体代谢及其与宿主生理学的相互作用
Caleb Cheng,Rüya Pakkan,Arul M Chinnaiyan et al.
Caleb Cheng et al.
Pancreatic ductal adenocarcinoma (PDAC) grows within a highly fibrotic, pressurized microenvironment that collapses vasculature and restricts delivery of oxygen and circulating nutrients. To survive this metabolic stress, PDAC cells activat...
Multiple quality control checkpoints safeguard small nuclear RNA biogenesis and prevent assembly of aberrant spliceosomes [0.03%]
多个质量控制检查点保障了小型核RNA的生成并防止了异常剪切体的装配
Tiantai Ma,Claire Huntington,Zhuoyi Song et al.
Tiantai Ma et al.
Defective small nuclear (sn)RNAs are produced from hundreds of human snRNA pseudogenes and mutant snRNA genes associated with human developmental disorders. Machineries that prevent defective snRNAs from disrupting pre-mRNA splicing remain ...
Adaptation of eukaryotic membrane homeostasis to species-specific cellular lipid landscapes [0.03%]
适应真核生物膜稳态以应对物种特异性细胞脂质景观的变化
Elisa Gomez-Gil,Paolo Guerra,Ying Gu et al.
Elisa Gomez-Gil et al.
The physicochemical properties of biological membranes must be maintained within a range compatible with cellular physiology. In the face of external perturbations, membrane lipid homeostasis mechanisms sense and control membrane features. ...