A lncRNA drives developmentally timed decay of all members of an essential microRNA family [0.03%]
一个长链非编码RNA驱动一个必需的微小RNA家族成员的发育时序降解
Acadia L Grimme,Lu Li,Alyshia Scholl et al.
Acadia L Grimme et al.
The spatiotemporal expression patterns of microRNAs (miRNAs) are crucial to their function. Target-directed miRNA degradation (TDMD) is an emerging regulatory module that contributes to these expression patterns wherein a specialized RNA (a...
Glc7/PP1 triggers Paf1 complex dissociation from RNA polymerase II to enable transcription termination [0.03%]
Glc7/PP1触发Paf1复合物从RNA聚合酶II解离以实现转录终止
Sanchirmaa Namjilsuren,Karen M Arndt
Sanchirmaa Namjilsuren
The mechanisms that control the dynamic composition of RNAPII elongation complexes govern major transitions in the transcription cycle yet are poorly understood. Here, we show that the transcription elongation factor Spt5 determines elongat...
Structure, function, regulation, evolution, and therapeutic implications of PARP14 [0.03%]
PARP14的结构、功能、调控、进化及药理学意义
Pulak Kar,Nina Đukić,Dragana Ahel et al.
Pulak Kar et al.
ADP-ribosylation (ADPr) is a posttranslational modification conserved across all domains of life that regulates a wide variety of processes. Among ADP-ribosyl transferases (ARTs) in humans, PARP14 has emerged as a key regulator involved in ...
α-Satellite RNA marks the perinucleolar compartment and represses ribosomal RNA expression in naive human embryonic stem cells [0.03%]
α-卫星RNA标记未分化的胚胎干细胞中的核仁周腔并抑制核糖体RNA表达
Kirti Mittal,Lamisa Ataei,Miguel Ramalho-Santos
Kirti Mittal
While most newly synthesized RNA is exported to the cytoplasm, a portion of noncoding RNA is retained in the nucleus and remains highly associated with chromatin. The strong binding of this RNA fraction to insoluble chromatin impairs its re...
Loss of the tumor suppressor PTEN activates cell-intrinsic interferon signaling to drive immune resistance [0.03%]
抑癌因子PTEN的丧失通过激活细胞内在干扰素信号传导来诱导免疫抵抗性
Yubao Wang,Cherubin Manokaran,Yutian Zou et al.
Yubao Wang et al.
Loss of the tumor suppressor PTEN is strongly associated with a lack of response to immune checkpoint blockade therapies in cancer patients, but the underlying mechanisms are not fully understood. We have developed a transformation model wh...
Chromatin binding and N-terminal domains of DNMT3B1 confer specificity for developmentally regulated CpG island methylation [0.03%]
DNMT3B1的染色质结合和N端结构域对其特异性修饰发育过程中的CpG岛甲基化的作用
Komal Yasmin,Tatyana B Nesterova,Neil Brockdorff
Komal Yasmin
CpG methylation in mammalian genomes is established by the closely related de novo DNA methyltransferases DNMT3A and DNMT3B. While both enzymes contribute to genome-wide CpG methylation, DNMT3B has a unique role in developmentally regulated...
Chrysanthi Moschandrea,Christian Frezza
Chrysanthi Moschandrea
An emerging paradox in cancer metabolism is that identical oncogenic mutations produce profoundly different metabolic phenotypes depending on tissue context, with many mutations exhibiting striking tissue-restricted distributions. Here we i...
The conserved N-terminal SANT1-binding domain (SBD) of EZH2 regulates PRC2 activity [0.03%]
EZH2的保守N端SANT1结合域（SBD）可调节PRC2活性
Agata L Patriotis,Douglas W Barrows,Yadira Soto-Feliciano et al.
Agata L Patriotis et al.
Polycomb group proteins maintain gene expression patterns established during early development, with Polycomb repressive complex 2 (PRC2) methyltransferase being a key regulator of cell differentiation, identity, and plasticity. Consequentl...
Bypass of blocking lesions by RNAPII reveals a novel stress induced by DNA damage [0.03%]
RNA聚合酶II绕过阻塞病变揭示DNA损伤诱导的新应激反应
Carolina P Bañuelos,Lucas D Caeiro,Pradeepkumar R Cingaram et al.
Carolina P Bañuelos et al.
Platinum-based compounds and ultraviolet (UV) irradiation produce bulky DNA lesions that stall RNA polymerase II (RNAPII), activating transcription-coupled nucleotide excision repair (TC-NER), RNAPII degradation, and global transcriptional ...
Multiomic analysis of clonal development reveals new regulators of leukemic cell growth [0.03%]
克隆发育的多组学分析揭示新的白血病细胞生长调节因子
Gracia Bonilla,Alexander Morris,Sharmistha Kundu et al.
Gracia Bonilla et al.
Mechanisms driving the increase in cell growth in developing leukemia are not fully understood. We focused on epigenomic regulation of this process by analyzing the changes of chromatin marks and gene expression in leukemic cell clones as t...