DDX3X-mediated translation of structured cardiac mRNAs is essential for female heart development [0.03%]
DDX3X介导的心脏结构mRNA翻译对女性心脏发育至关重要
Kayla K Mason,Seohyun K Park,James I Emerson et al.
Kayla K Mason et al.
Sex differences influence congenital heart disease (CHD) development, yet underlying molecular mechanisms remain largely unclear. We demonstrate that the X-linked RNA helicase DDX3X associates in the heart with ribosomal subunit proteins, a...
MLL4/KMT2D histone methyltransferase and JUNB cooperate in a feed-forward loop to support AP-1-dependent TGF-β signaling [0.03%]
MLL4/KMT2D组蛋白甲基转移酶与JUNB通过正反馈回路共同作用以支持AP-1依赖型TGF-β信号转导
Timothy En Haw Chan,Md Saiful Islam,Omid Fotouhi et al.
Timothy En Haw Chan et al.
Transforming growth factor β (TGF-β) signaling is a highly pleiotropic pathway with an important role in development, homeostasis, and cancer. Chromatin regulators contribute to the regulation of TGF-β-responsive transcription. The requi...
Modeling medulloblastoma pathogenesis and treatment in human cerebellar organoids [0.03%]
人脑小脑类器官中的髓母细胞瘤发生及治疗模型构建
Thomas Willott,James G Nicholson,Xinyu Zhang et al.
Thomas Willott et al.
Medulloblastoma (MB) groups 3 and 4 arise from human-specific developmental contexts that remain experimentally inaccessible, limiting mechanistic insight into tumor initiation. We generated cerebellar organoids (CbOs) from expanded potenti...
Rethinking HNF1A-MODY: HNF1A at the crossroads of development and multiorgan metabolic disease [0.03%]
重新思考HNF1A-MODY：HNF1A在发育和多器官代谢疾病交叉路口的作用
Julie Warin,Anne Grapin-Botton
Julie Warin
In this issue of Genes & Development, Unger and colleagues (doi:10.1101/gad.353153.125) combined human pluripotent stem cell-derived in vitro models with targeted in vivo mouse models to reveal multiple developmental defects triggered by HN...
Neural stem cell epigenomes and fate bias are temporally coordinated during mouse cortical development [0.03%]
小鼠皮层发育过程中神经干细胞的表观基因组和命运偏向具有时间相关性
Yonatan Shapira,Florian Noack,Silvia Vangelisti et al.
Yonatan Shapira et al.
During cortical development, neural stem cells (NSCs) combine self-renewal with the sequential production of different subtypes of projection neurons as well as glia cells. How the NSC epigenome accommodates this over time remains unresolve...
The microprotein SMIM26 connects metabolite transporters of the outer and inner mitochondrial membranes and is essential for respiratory chain function [0.03%]
微蛋白SMIM26连接线粒体内外膜代谢物转运蛋白并参与呼吸链功能的维持
Kevin Heizler,Anastasia Chugunova,Mara Hofmann et al.
Kevin Heizler et al.
Microproteins represent a class of short polypeptides with very diverse cellular functions. Microproteins frequently escape proteomics-based identification, making the extent and potential functions of small proteins largely elusive. Some m...
KLF18 is a necessary component of the DUX4-initiated transcriptional network and a candidate locus for phenotypic diversity [0.03%]
KLF18是DUX4启动转录网络的必要组成部分，并且是表型多样性的候选基因位点
Danielle C Hamm,Aidan B O&#x;Donnell,Sean R Bennett et al.
Danielle C Hamm et al.
DUX4 initiates the first wave of zygotic genome activation (ZGA) in the human embryo, and its misexpression in skeletal muscle causes facioscapulohumeral muscular dystrophy (FSHD). However, other factors that help regulate ZGA-like transcri...
Temporal loss of En1 during limb development causes distinct phenotypes [0.03%]
肢体发育期间En1的暂时丧失导致不同的表型特征
Alessa R Ringel,Natalia Benetti,Andreas Magg et al.
Alessa R Ringel et al.
The precise spatiotemporal regulation of developmental genes is required for proper organogenesis. Engrailed-1 (En1) is essential for dorsal-ventral patterning during mouse limb development from embryonic day 9.5 (E9.5) to E11.5. Previously...
Cohesin-mediated loop extrusion and enhancer-associated factors additively contribute to Sox2 looping with its distal enhancer [0.03%]
共hesin介导的环挤出和增强子相关因子加性促进Sox2与远端增强子形成染色质环化
Moreno Martinovic,Koen D Flach,Marit A C de Kort et al.
Moreno Martinovic et al.
Sox2 expression is regulated by a distal enhancer cluster known as the Sox2 control region (SCR). Although Sox2 and the SCR exhibit strong interactions in chromosome conformation capture experiments, acute depletion of cohesin only mildly a...
DAXX directs dual modes of H3.4-to-H3.3 histone replacement in the male germline [0.03%]
DAXX 在雄性生殖细胞中指导H3.4向H3.3组蛋白替代的双模式机制
Yu-Han Yeh,Mengwen Hu,Kai Otsuka et al.
Yu-Han Yeh et al.
During spermatogenesis, extensive chromatin remodeling and histone replacement reshape the male germline epigenome. Although HIRA mediates transcription-coupled incorporation of histone variant H3.3, we identified DAXX as a key histone chap...