A brain-specific microRNA, miR-1000, regulates lipid homeostasis via neuropeptide-like precursor 1 in Drosophila melanogaster [0.03%]
果蝇脑特异性微小核糖核酸miR-1000通过神经肽前体蛋白1调节脂质稳态
Pushpa Verma,Pruthvi Gowda,Nika N Danial et al.
Pushpa Verma et al.
Metabolism requires precise gene regulation to balance energy intake and expenditure for an organism's well-being, with misregulation often leading to metabolic syndromes. This study reveals that the brain-specific microRNA miR-1000 regulat...
Separable roles for Microprocessor and its cofactors, ERH and SAFB1/2, during microRNA cluster assistance [0.03%]
微处理器及其辅助因子ERH和SAFB1/2在协助微小核糖核酸簇加工过程中的分离作用
Renfu Shang,Niko Popitsch,Seungjae Lee et al.
Renfu Shang et al.
While most conserved microRNA (miRNA) transcripts harbor a suite of features that mediate their efficient biogenesis into small RNAs, some loci bear suboptimal attributes that enable additional layers of processing regulation. A notable exa...
Retrotransposon activation during spermatogenesis achieves massive ecDNA biogenesis but rare integration [0.03%]
精子发生过程中逆转座子激活实现大量的ecDNA产生但罕见整合
Lauren Tracy,Yao Chen,Zz Zhao Zhang
Lauren Tracy
Retrotransposon mobilization in germline cells enables the rewriting of genetic information to drive genome innovation, species evolution, and adaptation through the generation of de novo mutations. However, uncontrolled mobilization can ca...
Exosome-mediated decay of unstable long extended precursors of human telomerase RNA is dependent on 5'-cap trimethylation [0.03%]
小泡介导的不稳定的人类端粒酶RNA长前体的降解依赖于5'-帽的三甲基化
Aniruddha Samajdar,Roberta Amato,Seongmoon Jo et al.
Aniruddha Samajdar et al.
Mutations that impact maturation of human telomerase RNA (hTR) are common in telomere biology disorders. Here, we describe sequential posttranscriptional modifications that coordinate hTR biogenesis and decay. Initially, TGS1-mediated 5'-ca...
tRNA synthetase activity is required for stress granule and P-body assembly [0.03%]
tRNA合成酶活性要求应激颗粒和P体组装
Max Baymiller,Noah S Helton,Benjamin Dodd et al.
Max Baymiller et al.
Translation elongation defects activate the integrated stress response (ISR), but whether and how ribosome stalls are cleared to enable mRNA release for ribonucleoprotein (RNP) granule assembly remain unclear. We show that blocking tRNA ami...
Independent control of neurogenesis and dorsoventral patterning by NKX2-2 [0.03%]
NKX2-2对神经发生和背腹模式形成独立调控的作用
Sumin Jang,Elena V Abarinov,Julie A Dobkin et al.
Sumin Jang et al.
Human neurogenesis is disproportionately protracted, lasting >10 times longer than in mice, allowing neural progenitors to undergo more rounds of self-renewing cell divisions and generate larger neuronal populations. In the human spinal cor...
Corrigendum: Fine-tuning p53 activity by modulating the interaction between eukaryotic translation initiation factor eIF4E and RNA-binding protein RBM38 [0.03%]
更正：通过调节真核起始因子eIF4E与RNA结合蛋白RBM38的相互作用来微调p53活性
Wenqiang Sun,Kyra Laubach,Christopher Lucchessi et al.
Wenqiang Sun et al.
Published Erratum
Genes & development. 2026 Jan 1;40(1-2):142. DOI:10.1101/gad.353489.125 2026
The LINC complex component Kms1 and CENP-B protein Cbp1 cooperate to enforce faithful homology-directed DNA repair at the nuclear periphery in S. pombe [0.03%]
LINC复合物成员Kms1和CENP-B蛋白Cbp1在S. pombe核周协同作用以实现忠实的同源介导的DNA修复
Alyssa Laffitte,Dongxu Lin,Yingzhen Jenny Tian et al.
Alyssa Laffitte et al.
While homologous recombination (HR) is often considered to be an error-free DNA repair mechanism, the fidelity of this pathway depends on the cell's ability to engage the ideal template: the replicated sister chromatid. This is particularly...
Chromatin architecture reprogramming reveals novel epigenetic dependencies in breast cancer [0.03%]
染色质结构的重新编程揭示了乳腺癌中的新型表观遗传学依赖性
Liliana Garcia-Martinez,Mengsheng Zha,Rodrigo L Borges et al.
Liliana Garcia-Martinez et al.
Chromatin architecture plays a key role in development and cancer, yet most studies lack mechanistic depth due to widespread epigenomic remodeling. To address this, we tracked chromatin structure dynamics during the progression of endocrine...
F Nafrisha Cassim Bawa,Mitchell A Lazar
F Nafrisha Cassim Bawa
Nuclear receptors (NRs) are ligand-regulated transcription factors (TFs) that respond to hormonal, nutritional, and environmental signals. NRs as druggable targets are known for their therapeutic potential in treating a wide range of diseas...