Laura A Lindsey-Boltz,Aziz Sancar
Laura A Lindsey-Boltz
During DNA replication, the physical and functional coupling of DNA unwinding by the CMG helicase with the DNA synthesis components of the replisome promotes highly efficient replication of the genome. What happens when the replication fork...
Emily J Park,Florencia Levin-Ferreyra,Bruno Di Stefano
Emily J Park
Differentiation requires coordinated exit from the stem cell state, during which gene regulatory networks sustaining self-renewal are dismantled, while lineage-specific programs are activated. This transition is governed by chromatin modifi...
Evolutionarily conserved spliceosome-exosome pathway in nuclear mRNA surveillance [0.03%]
进化上保守的核糖体途径在核mRNA监测中的作用
Daniel K Abbas,Fabien Bonneau,Max E Wilkinson et al.
Daniel K Abbas et al.
Intron-containing mRNAs are cotranscriptionally spliced and assembled into messenger ribonucleoprotein (mRNP) particles, a process monitored by surveillance pathways. Here, we combined biochemical and structural approaches to elucidate the ...
CDK1 and CEP97 cooperatively control centriole length to orchestrate ciliogenesis and developmental patterning [0.03%]
CDK1和CEP97通过协同控制中心粒长度来协调纤毛发生及发育模式化
Yue Liu,Zhengmao Wang,Tanvi Sinha et al.
Yue Liu et al.
Architecture is critical for organelle function. The lengths of centrioles, key components of centrosomes, are tightly regulated. We adapted centrosome purification approaches to measure centrosomal protein phosphorylation. Centrosome-speci...
Coupling of translesion synthesis with the replisome stabilized at stalled replication forks by ATR [0.03%]
ATR介导的停滞复制叉上校正酶与复制机器的偶联机制研究
Jung-Hoon Yoon,Karthi Sellamuthu,Robert E Johnson et al.
Jung-Hoon Yoon et al.
By promoting replication through DNA lesions, translesion synthesis (TLS) DNA polymerases protect against chromosomal instability and tumorigenesis. However, it is not known whether TLS in mammalian cells operates in conjunction with the re...
MYC serine 62 phosphorylation promotes its association with DNA double-strand breaks to facilitate repair and cell survival under genotoxic stress [0.03%]
MYC的丝氨酸62磷酸化促进其与DNA双链断裂相关联以促进基因毒性压力下的修复和细胞存活
Gabriel M Cohn,Colin J Daniel,Jennifer R Eng et al.
Gabriel M Cohn et al.
Genomic instability is a hallmark of cancer, driving oncogenic mutations that enhance tumor aggressiveness and drug resistance. MYC, a master transcription factor that is deregulated in nearly all human tumors, paradoxically induces replica...
The competition between splicing and 3' processing shapes the human transcriptome [0.03%]
剪接与3′端加工间的竞争关系塑造着人类转录组
Lindsey V Soles,Shuangyu Li,Liang Liu et al.
Lindsey V Soles et al.
Eukaryotic pre-mRNA processing steps, including splicing and 3' processing, are tightly coordinated, yet the underlying mechanisms remain incompletely understood. U1 snRNP has been proposed to inhibit 3' processing at intronic polyadenylati...
Cleavage of the RNA polymerase II general transcription factor TFIIB tunes transcription during stress [0.03%]
RNA聚合酶II通用转录因子TFIIB在压力条件下的切割調節了轉錄过程
Leah Gulyas,Azra Lari,Sahil B Shah et al.
Leah Gulyas et al.
Cellular stressors often cause widespread repression of RNA polymerase II (RNAP II) activity, which is thought to facilitate a focused transcriptional output toward stress resolution. In many cases, however, the underlying regulatory mechan...
STK38/L promote tissue growth and cancer by inhibiting the Hippo pathway [0.03%]
STK38/L通过抑制Hippo通路促进组织生长和癌症生成
Jeongmin An,Zhen Huang,Amrutha Kizhedathu et al.
Jeongmin An et al.
The Hippo pathway is a key regulator of development, regeneration, tissue homeostasis, and organ size, and its dysregulation promotes tumorigenesis. However, the precise mechanisms of its regulation in both normal physiology and cancer rema...
DDX3X-mediated translation of structured cardiac mRNAs is essential for female heart development [0.03%]
DDX3X介导的心脏结构mRNA翻译对女性心脏发育至关重要
Kayla K Mason,Seohyun K Park,James I Emerson et al.
Kayla K Mason et al.
Sex differences influence congenital heart disease (CHD) development, yet underlying molecular mechanisms remain largely unclear. We demonstrate that the X-linked RNA helicase DDX3X associates in the heart with ribosomal subunit proteins, a...