PHA-4/FoxA controls the function of pharyngeal and extrapharyngeal enteric neurons in C. elegans [0.03%]
PHA-4/FoxA控制C. elegans咽部和非咽部肠神经元的功能
Zion Walker,Wen Xi Cao,Eduardo Leyva-Díaz et al.
Zion Walker et al.
FoxA transcription factors pattern gut tissue across animal phylogeny. Beyond their early patterning function, little is known about whether they control the terminal differentiation and/or function of the fully mature enteric nervous syste...
Corrigendum: A germline point mutation in the MYC-FBW7 phosphodegron initiates hematopoietic malignancies [0.03%]
端粒酶启动子点突变通过MYC-FBW7经典信号轴驱动血液系统恶性肿瘤发起的校正说明文：MYC-FBW7磷酸化靶向降解基序的生殖系点突变引发造血系统恶性肿瘤
Brian Freie,Patrick A Carroll,Barbara J Varnum-Finney et al.
Brian Freie et al.
Published Erratum
Genes & development. 2025 Dec 1;39(23-24):1509. DOI:10.1101/gad.353345.125 2025
Corrigendum: Sept4/ARTS is required for stem cell apoptosis and tumor suppression [0.03%]
秋水仙素4/ARTS对干细胞凋亡和肿瘤抑制的作用不容忽视的更正公告
María García-Fernández,Holger Kissel,Samara Brown et al.
María García-Fernández et al.
Published Erratum
Genes & development. 2025 Dec 1;39(23-24):1510. DOI:10.1101/gad.353378.125 2025
Gamete fusion triggers cytosolic functions and P-body recruitment of the RNA-binding protein Mei2 to drive fission yeast zygotic development [0.03%]
受精触发RNA结合蛋白Mei2的细胞质功能和P体募集以驱动裂殖酵母合子发育
Ayokunle Araoyinbo,Clàudia Salat-Canela,Aleksandar Vještica
Ayokunle Araoyinbo
Compartmentalized regulation of RNAs is emerging as a key driver of developmental transitions, with RNA-binding proteins performing specialized functions in different subcellular compartments. The RNA-binding protein Mei2, which arrests mit...
Ashley P Ng,Stephen L Nutt
Ashley P Ng
The production of B cells is essential for a functional immune system. This process relies on the coordinated activity of a handful of transcription factors that act in part by modifying the chromatin landscape of lymphoid progenitors to al...
Intrinsically disordered regions stimulate concentration of small nucleolar ribonucleoproteins and formation of Cajal bodies and nucleoli [0.03%]
内在无序区域可刺激小核仁RNA颗粒的浓缩及Cajal体和核仁的形成
Koceila Meznad,Manisha Deogharia,Ludivine Wacheul et al.
Koceila Meznad et al.
One of the densest compartments in the cell is the dense fibrillar component (DFC) of the nucleolus, consisting mainly of nascent ribosomal RNA (rRNA), small nucleolar ribonucleoproteins (snoRNPs), and their chaperone, Nopp140 (gene name NO...
Hunchback functions in the postmitotic larval MDN to restrict axon outgrowth, synapse formation, and backward locomotion [0.03%]
无分裂能力的MDN中的Hunchback限制轴突生长、突触形成和向后运动
Kristen Lee,Natalie Rico Carvajal,Josmarie Graciani et al.
Kristen Lee et al.
During neurodevelopment, a single progenitor cell can generate many different neuron types. As these neurons mature, they form unique morphologies, integrate into neural circuits, and contribute to behavior. However, the integration of thes...
Potent synthetic lethality between PLK1 and EYA family inhibitors in tumors of the central and peripheral nervous systems [0.03%]
PLK1与EYA家族抑制剂在中枢和周围神经系统肿瘤中的强力合成致死作用
Christopher B Nelson,Jadon K Wells,Ekaagra Kesarwani et al.
Christopher B Nelson et al.
The Eyes Absent family of protein phosphatases (EYA1-4) is aberrantly expressed and tumor-promoting across many devastating cancers of neurological origin affecting both children and adults. It has recently been demonstrated that EYA1 and E...
Johanna Tingvall-Gustafsson,Kim Hellerstedt,Jonas Ungerbäck et al.
Johanna Tingvall-Gustafsson et al.
To increase our understanding of the interplay between transcription factor networks and the epigenetic landscape in early B-lymphoid development, we conducted combined SC-RNA/ATAC-seq analyses of bone marrow progenitor populations. Based o...
Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503 [0.03%]
PLAGL1和LRRC58通过诱导miR-322和miR-503的靶点触发的microRNA降解来控制哺乳动物体型大小
Collette A LaVigne,Jaeil Han,He Zhang et al.
Collette A LaVigne et al.
Precise control of microRNA (miRNA) expression is critical during development. An important mechanism of miRNA regulation is target-directed microRNA degradation (TDMD), a pathway in which the binding of miRNAs to specialized trigger RNAs i...