The eukaryotic homology search complex distorts donor DNA structure to probe for homology [0.03%]
真核生物同源搜索复合物扭曲供体DNA结构以探究同源性
Mitchell V Woodhouse,Jingyi Hu,Meiling Wu et al.
Mitchell V Woodhouse et al.
Homologous recombination (HR) is a DNA double-strand break repair pathway that facilitates genetic exchange and protects damaged replication forks during DNA synthesis. As a template-based repair process, the successful repair of a double-s...
Lights up on the embryonic dance: tools and applications of optogenetics in developmental biology [0.03%]
点亮胚胎发育的舞蹈：光遗传学在发育生物学中的工具与应用
Yang Gao,Emily K Ho,Jared E Toettcher
Yang Gao
In developmental biology, cellular events must be orchestrated at precise times and locations in the embryo. Many classic discoveries were achieved by perturbing developmental organization using approaches ranging from tissue transplantatio...
Defective HNF1A hinders GLI3 processing favoring duodenal versus pancreatic fate, thus leading to intestinal elongation in vivo [0.03%]
缺陷HNF1A会妨碍GLI3的处理过程，从而有利于十二指肠而非胰腺的命运，导致体内肠道延长
Lucas Unger,Ulrik Larsen,Thomas Aga Legøy et al.
Lucas Unger et al.
Regulatory circuits driving regional cell fate specification and lineage restriction decisions are not fully understood. The molecular mechanisms by which Hedgehog signaling controls lineage segregation in the posterior foregut remain uncle...
Amy E Pasquinelli
Amy E Pasquinelli
MicroRNAs (miRNAs) regulate gene expression by recruiting Argonaute (AGO) proteins to specific targets, forming the microRNA (miRNA)-induced silencing complex (miRISC). In this issue of Genes & Development, Grimme and colleagues (doi:10.110...
Nested pediatric low-grade glioma cerebral organoid avatars reveal glutamatergic neuron stromal growth dependency [0.03%]
嵌套的儿童低级别胶质瘤类脑器官揭示了神经元间质生长依赖性
Enquan Xu,Christina Zhang,Fausto J Rodriguez et al.
Enquan Xu et al.
Pilocytic astrocytomas (PAs), the most common pediatric brain tumor, grow slowly and depend heavily on their local brain microenvironment, hindering accurate humanized model development. To surmount this barrier, we developed mixed assemblo...
mRNA 3' UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth [0.03%]
编码mRNA的3′UTR通过引导microRNA降解参与印记基因网络并调节生长
Daniel H Lin,Lara E Elcavage,Ekaterina Khalizeva et al.
Daniel H Lin et al.
MicroRNAs direct downregulation of target mRNAs. Sometimes, however, this regulatory paradigm inverts, and a target RNA triggers degradation of a microRNA. This target-directed microRNA degradation (TDMD) requires ZSWIM8. Zswim8 -/- mice ex...
Shan Zha,Geunil Yi
Shan Zha
The nonhomologous end joining (NHEJ) pathway is a major mechanism for repairing DNA double-strand breaks (DSBs), essential for lymphocyte development and for maintaining genome stability in postmitotic cells, including neurons. Under pathol...
Embryonic stem cell factors DPPA2/4 amplify active H3K4me3-H2AK119ub chromatin domains in non-small cell lung cancer [0.03%]
胚胎干细胞因素DPPA2/4可放大非小细胞肺癌中的组蛋白修饰区域H3K4me3-H2AK119ub染色质域
Janith A Seneviratne,Clare L Crisp,Eleanor Glancy et al.
Janith A Seneviratne et al.
Embryonic regulators are often re-expressed in cancers; however, the functional and molecular significance of this is not always understood. The epigenetic priming factors developmental pluripotency-associated 2 and 4 (DPPA2/4) have crucial...
A lncRNA drives developmentally timed decay of all members of an essential microRNA family [0.03%]
一个长链非编码RNA驱动一个必需的微小RNA家族成员的发育时序降解
Acadia L Grimme,Lu Li,Alyshia Scholl et al.
Acadia L Grimme et al.
The spatiotemporal expression patterns of microRNAs (miRNAs) are crucial to their function. Target-directed miRNA degradation (TDMD) is an emerging regulatory module that contributes to these expression patterns wherein a specialized RNA (a...
Glc7/PP1 triggers Paf1 complex dissociation from RNA polymerase II to enable transcription termination [0.03%]
Glc7/PP1触发Paf1复合物从RNA聚合酶II解离以实现转录终止
Sanchirmaa Namjilsuren,Karen M Arndt
Sanchirmaa Namjilsuren
The mechanisms that control the dynamic composition of RNAPII elongation complexes govern major transitions in the transcription cycle yet are poorly understood. Here, we show that the transcription elongation factor Spt5 determines elongat...