"Clinical Evidence and Critical Review of Mesenchymal Stromal Cells for Corneal and Ocular Surface Diseases" [0.03%]
间充质基质细胞治疗角膜及眼表疾病临床证据及批判性评价
Grace C Tu,Seyyedehfatemeh Ghalibafan,Farshad Abedi et al.
Grace C Tu et al.
Mesenchymal stromal cells (MSCs), owing to their regenerative and immunomodulatory properties, have emerged as a potential therapeutic option for disorders affecting the cornea and ocular surface. Early-phase clinical studies have begun to ...
Differential Effects of Various Cytokine Priming on T Cell Suppression and Migration in Canine Mesenchymal Stem Cells [0.03%]
细胞因子诱导的犬间充质干细胞对T细胞抑制和介导作用的影响差异研究
Chan-Hee Jo,Sang-Yun Lee,Young-Bum Son et al.
Chan-Hee Jo et al.
Mesenchymal stem cells have been widely studied for treating immune-mediated diseases due to their immunomodulatory abilities. Recent studies have shown that priming MSCs with inflammatory cytokines can enhance these functions, yet the opti...
Rahul Chaudhary,Brittany A Cordova,Marcus Hong et al.
Rahul Chaudhary et al.
Hematopoietic aging is characterized by diminished stem cell regenerative capacity and an increased risk of hematologic dysfunction. We previously identified that the prostaglandin-degrading enzyme 15-hydroxyprostaglandin dehydrogenase (15-...
Stem Cells within the HPA Axis in Tissue Homeostasis and Disease [0.03%]
下丘脑-垂体-肾上腺轴中的干细胞在组织稳态及疾病中的作用
Mario Schubert,Kaomei Guan,Charlotte Steenblock
Mario Schubert
The hypothalamus-pituitary-adrenal (HPA) axis is crucial for the energy metabolism, cardiovascular function, and stress response. Importantly, neuronal signalling circuits in the hypothalamus, along with hormones released from the pituitary...
A novel trained mesenchymal stromal cell-based therapy, HXB-319, effectively controls progressive glomerulonephritis in a murine lupus model [0.03%]
一种新型的基于间充质基质细胞的治疗方法HXB-319可有效控制小鼠狼疮模型中进行性肾小球肾炎
Hulya Bukulmez,Adrienne Dennis,Jane Reese et al.
Hulya Bukulmez et al.
Introduction: Systemic lupus erythematosus (SLE) is driven by abnormal type-I and -II interferon activation, affecting a variety of immunocompetent cells. Mesenchymal stromal cells (MSCs) can modulate inflammation but oft...
Healthy human induced pluripotent stem cell-derived cardiomyocytes exhibit sex dimorphism even without the addition of hormones [0.03%]
健康的人类多能干细胞源心肌细胞性别二态性及其激素调控机制
Sophie E Givens,Abygail A Andebrhan,Eric G Schmuck et al.
Sophie E Givens et al.
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are a valuable cell type for studying human cardiac health and disease in vitro. However, it is not known whether hiPSC-CM display sex dimorphism and therefore whether se...
Consistent self-organized emergence of hyaline cartilage in hiPSC-derived multi-tissue organoids [0.03%]
人诱导多能干细胞来源的含多种组织的类器官中透明软骨的一致性自组织形成
Huzefa I Husain,Manci Li,Juan E Abrahante et al.
Huzefa I Husain et al.
Existing protocols for in vitro hyaline cartilage production utilizing human induced pluripotent stem cells (hiPSCs) have several challenges including a complex culturing process that uses undefined culture media, phenotypic instability, an...
Single-cell analysis of heterogeneity and molecular changes in cultured corneal epithelial stem cells during serial passage [0.03%]
单细胞分析培养角膜干细胞传代过程中的异质性和分子变化
Usanee Reinprayoon,Supaporn Khramchantuk,Natthida Kittimawikrom et al.
Usanee Reinprayoon et al.
The maintenance of corneal epithelial homeostasis relies on limbal stem cells (LSCs) located at the limbus. Although short-term cultured LSC transplantation effectively treats LSC deficiency, prolonged culture leads to stemness loss and abo...
m6A mRNA demethylase FTO promotes chondrogenic differentiation of human bone marrow mesenchymal stem cells by targeting SMAD3 [0.03%]
FTO通过靶向SMAD3促进人骨髓间充质干细胞软骨分化
Tao Shu,Dongfeng Zhang,Jiachun Li et al.
Tao Shu et al.
Bone marrow mesenchymal stem cells (BMSCs) have chondrogenic differentiation potential to treat cartilage injury. N6 methyladenosine (m6A), one of the most prevalent mRNA modification, has been reported to be crucial in cartilage disease. H...