Molecular signature and regulatory network of human umbilical cord mesenchymal stromal cells as a niche for hematopoietic stem cells and progenitors [0.03%]
人脐带间充质基质细胞作为造血干细胞和祖细胞生态位的分子特征与调控网络
Pornprapa Srimorkun,Kittisak Suanpan,Korakot Atjanasuppat et al.
Pornprapa Srimorkun et al.
The fate of hematopoietic stem cells (HSCs) is determined by a complex regulatory network supporting self-renewal and quiescence within a niche. Umbilical cord mesenchymal stromal cells (UC-MSCs) are classified as an alternative niche for t...
Resistance to Naive and Formative Pluripotency Conversion in RSeT Human Embryonic Stem Cells [0.03%]
RSeT人胚胎干细胞中抵抗原始态和起始态多能性重编程的耐受性
Kevin G Chen,Kory R Johnson,Kyeyoon Park et al.
Kevin G Chen et al.
One of the most important properties of human embryonic stem cells (hESCs) is their ability to exist in primed and naive pluripotent states. Our previous meta-analysis indicated the existence of heterogeneous pluripotent states derived from...
Giant Panda Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Promote Dermal Fibroblast Proliferation and Wound Healing [0.03%]
大熊猫脐带间充质干细胞源性外泌体促进成纤维细胞增殖和创面修复
Yuliang Liu,Hongyan Li,Yuan Li et al.
Yuliang Liu et al.
Umbilical cord mesenchymal stem cell-derived exosomes (UC-MSC-Exos) represent a potential therapeutic solution for captive giant pandas. The aim of this study was elucidating the proteomic and microRNA (miRNA) profiles and discerning their ...
A molecular systems architecture of the mesenchymal stromal cell microenvironment [0.03%]
间充质基质细胞微环境的分子系统架构
V A Shiva Ayyadurai,Prabhakar Deonikar,Vishvatha Radhakrishnan et al.
V A Shiva Ayyadurai et al.
A systems-level understanding of immunomodulatory, regenerative, and pro-/antifibrosis functions of mesenchymal stromal cells (MSCs) is critical to advance MSCs as a viable therapeutic option. Given the complexity of MSCs and their interact...
Human Obesity Decreases the Anti-inflammatory Functionality of Adipose Tissue-Derived Mesenchymal Stem/Stomal Cells by Upregulating IL-1β Expression [0.03%]
肥胖通过上调IL-1β表达降低来自脂肪组织源间充质干细胞/血管内皮细胞的抗炎功能
Authors Li Xing,Xiangyang Zhu,Nattawat Klomjit et al.
Authors Li Xing et al.
Background: Mesenchymal stromal cells (MSCs) possess therapeutic properties that mediate repair. Obesity impairs MSC functionality and therapeutic efficacy, possibly by eliciting dynamic modifications of epigenetic marker...
Brain pericytes derived from human pluripotent stem cells retain vascular and phagocytic functions under hypoxia [0.03%]
人多能干细胞衍生的脑周细胞在缺氧条件下保留血管和吞噬功能
Mingzi Zhang,Youbin Kim,Allison Bosworth et al.
Mingzi Zhang et al.
The integrity and function of the blood-brain barrier (BBB) are largely regulated by pericytes. Pericyte deficiency leads to BBB breakdown and neurological dysfunction in major neurological disorders including stroke and Alzheimer's disease...
Linking mitochondria, fatty acids and HSC expansion during infection: implications for aging and metabolic diseases [0.03%]
感染期间将线粒体、脂肪酸和造血干细胞扩增相联系：对衰老和代谢性疾病的意义
Katherine Hampton,Alyssa Polski-Delve,Charlotte Hellmich et al.
Katherine Hampton et al.
In steady state, hematopoietic stem cells (HSCs) reside quiescently in their hypoxic niche with minimal mitochondrial activity, maintaining characteristically low levels of reactive oxygen species (ROS) and instead favoring glycolysis to me...
Loss of peroxisome function promotes oxidative stress induced hematopoiesis [0.03%]
过氧化物酶体功能丧失促进氧化应激诱导的造血作用
Emma A Schindhelm,Amada Blake,Megan M Constans et al.
Emma A Schindhelm et al.
The role of peroxisomes in hematopoiesis remains poorly understood. The PEX1-Gly844Asp knock-in mouse lacks peroxisome formation and is peroxisome deficient. We observed that peroxisome deficient animals had up to 50% greater numbers of per...
Neuronal branching in stem cell models of mitochondrial and neurological diseases [0.03%]
干细胞模型中的线粒体和神经疾病神经系统分支
Selene Lickfett,Carmen Menacho,Sidney Cambridge et al.
Selene Lickfett et al.
Neuronal branching, the extension and arborization of neurites, is critical for establishing and maintaining functional neural circuits. Emerging evidence suggests that mitochondria play an important role in regulating this process. In this...
Human cortical neurons rapidly generated by embryonic stem cell programming integrate into the stroke-injured rat cortex [0.03%]
人胚胎干细胞编程快速生成人大脑皮层神经元并整合到中风损伤的大鼠大脑皮质中
Raquel Martinez-Curiel,Mazin Hajy,Oleg Tsupykov et al.
Raquel Martinez-Curiel et al.
Stem cell sources capable of producing appropriate cells for replacement will be necessary for functional repair of the injured brain. Here, we have determined whether transcription factor programming of human embryonic stem (hES) cells can...