Cellular therapies for the prevention and treatment of acute graft-versus-host disease [0.03%]
用于预防和治疗急性移植物抗宿主病的细胞疗法
Daniel Peltier,Van Anh Do-Thi,Timothy Devos et al.
Daniel Peltier et al.
Acute graft-versus-host disease (aGVHD) is a major complication of allogeneic hematopoietic cell transplantation (allo-HCT) that is caused by donor immune cells attacking and damaging host tissues. Immune suppressive small molecule and prot...
Nephron progenitor fate is modulated by angiotensin type 1 receptor signaling in human kidney organoids [0.03%]
人肾脏器官中肾单位祖细胞的命运受血管紧张素1型受体信号的调节
Hyunjae Chung,Waleed Rahmani,Sarthak Sinha et al.
Hyunjae Chung et al.
The renin-angiotensin system (RAS) is essential for normal kidney development. Dysregulation of the RAS during embryogenesis can result in kidney abnormalities. To explore how angiotensin type 1 receptor (AT1R) signaling modulates nephron p...
Immunoregulatory iPSC-derived non-lymphoid progeny in autoimmunity and GVHD alloimmunity [0.03%]
自身免疫和GVHD同种免疫中的免疫调节性iPSC衍生非淋巴样后代
Lie Ma,Jordan Fink,Ke Yao et al.
Lie Ma et al.
Non-lymphoid immunoregulatory cells, including mesenchymal stem cells (MSCs), myeloid-derived suppressor cells (MDSCs), regulatory macrophages (Mregs), and tolerogenic dendritic cells (Tol-DCs), play critical roles in maintaining immune hom...
SARS-CoV2 infection triggers inflammatory conditions and astrogliosis-related gene expression in long-term human cortical organoids [0.03%]
SARS-CoV2感染触发长期人类皮质类器官中的炎性条件和星形胶质细胞相关基因表达
Mathilde Colinet,Ioana Chiver,Antonela Bonafina et al.
Mathilde Colinet et al.
SARS-CoV2, severe acute respiratory syndrome coronavirus 2, is frequently associated with neurological manifestations. Despite the presence of mild to severe CNS-related symptoms in a cohort of patients, there is no consensus whether the vi...
Patterning effects of FGF17 and cAMP on generation of dopaminergic progenitors for cell replacement therapy in Parkinson's disease [0.03%]
FGF17和cAMP在帕金森病细胞替代治疗中对多巴胺能祖细胞生成的图案效应
Amalie Holm Nygaard,Alrik L Schörling,Zehra Abay-Nørgaard et al.
Amalie Holm Nygaard et al.
Cell replacement therapies using human pluripotent stem cell-derived ventral midbrain (VM) dopaminergic (DA) progenitors are currently in clinical trials for treatment of Parkinson's disease (PD). Recapitulating developmental patterning cue...
Establishment of vascularized human retinal organoids from induced pluripotent stem cells [0.03%]
诱导性多能干细胞来源的血管化人类视网膜类器官的建立
Satoshi Inagaki,Shinsuke Nakamura,Yoshiki Kuse et al.
Satoshi Inagaki et al.
Stem cell-derived retinal organoids (ROs) have been investigated for applications in regenerative medicine, retinal disease models, and compound safety evaluation. Although the development of 3D organoids has provided novel opportunities fo...
The miR-290 and miR-302 clusters are essential for reprogramming of fibroblasts to induced pluripotent stem cells [0.03%]
miR-290和miR-302簇对于成纤维细胞重编程为诱导多能干细胞是必不可少的
Julia Ye,Ryan M Boileau,Ronald J Parchem et al.
Julia Ye et al.
The miR-290 and miR-302 clusters of microRNAs are highly expressed in naïve and primed pluripotent stem cells, respectively. Ectopic expression of the embryonic stem cell (ESC)-specific cell cycle regulating family of microRNAs arising fro...
Single-cell transcriptome sequencing in synovial joint: insights of new progenitors and targets in joint development and disease [0.03%]
滑膜关节的单细胞转录组测序：新的前体和靶点在关节发育及疾病中的启示
Ziqian Wang,Xianni Yang,Haopeng Yu et al.
Ziqian Wang et al.
Synovial joints, such as knee, temporomandibular, and spinal joints, play a key role in human movement and postural maintenance. Biological research has focused on understanding their developmental process and disease mechanisms. In recent ...
Raman Spectroscopies for Cancer Research and Clinical Applications: a Focus on Cancer Stem Cells [0.03%]
拉曼光谱在癌症研究和临床应用中的应用：重点关注癌症干细胞
Francesca Pagliari,Luca Tirinato,Enzo Di Fabrizio
Francesca Pagliari
Over the last two decades, research has increasingly focused on Cancer Stem Cells (CSCs), considered responsible for tumor formation, resistance to therapies, and relapse. The traditional "static" CSC model used to describe tumor heterogene...
Extracellular microvesicles/exosomes - magic bullets in horizontal transfer between cells of mitochondria and molecules regulating mitochondria activity [0.03%]
细胞外微囊/外泌体 - 在线粒体及调控线粒体活性的分子水平上细胞间水平转移中的神奇子弹
Mariusz Z Ratajczak,Kannathasan Thetchinamoorthy,Diana Wierzbicka et al.
Mariusz Z Ratajczak et al.
Extracellular microvesicles (ExMVs) were one of the first communication platforms between cells that emerged early in evolution. Evidence indicates that all types of cells secrete these small circular structures surrounded by a lipid membra...