Long Noncoding RNA-1604 Orchestrates Neural Differentiation through the miR-200c/ZEB Axis [0.03%]
长非编码RNA-1604通过miR-200c/ZEB轴调控神经分化
Rong Weng,Chenqi Lu,Xiaoqin Liu et al.
Rong Weng et al.
Clarifying the regulatory mechanisms of embryonic stem cell (ESC) neural differentiation is helpful not only for understanding neural development but also for obtaining high-quality neural progenitor cells required by stem cell therapy of n...
Retinoic Acid-Signaling Regulates the Proliferative and Neurogenic Capacity of Müller Glia-Derived Progenitor Cells in the Avian Retina [0.03%]
视黄酸信号通过调节鸡视网膜穆勒胶质细胞源性祖细胞的增殖和神经发生能力来影响再生效率
Levi Todd,Lilianna Suarez,Colin Quinn et al.
Levi Todd et al.
In the retina, Müller glia have the potential to become progenitor cells with the ability to proliferate and regenerate neurons. However, the ability of Müller glia-derived progenitor cells (MGPCs) to proliferate and produce neurons is li...
Low Osteogenic Yield in Human Pluripotent Stem Cells Associates with Differential Neural Crest Promoter Methylation [0.03%]
人多能干细胞成骨量低与神经嵴启动子甲基化差异有关
Nicole Renee Lee Sparks,Ivann Kenneth Carvajal Martinez,Cristina Helen Soto et al.
Nicole Renee Lee Sparks et al.
Human pluripotent stem cell-derived osteoblasts possess great potential for use in bone disorder elucidation and repair; however, while the general ability of human pluripotent stem cells to differentiate into osteoblasts and lay down bone-...
Concise Review: The Use of Stem Cells for Understanding and Treating Huntington's Disease [0.03%]
简报：干细胞在亨廷顿舞蹈病研究和治疗中的应用
Bronwen Connor
Bronwen Connor
Two decades ago, researchers identified that a CAG expansion mutation in the huntingtin (HTT) gene was involved in the pathogenesis of Huntington's disease (HD). However, since the identification of the HTT gene, there has been no advance i...
Notch Signaling Controls Transdifferentiation of Pulmonary Neuroendocrine Cells in Response to Lung Injury [0.03%]
诺特CHED信号控制肺神经内分泌细胞在肺损伤后的转分化现象
Erica Yao,Chuwen Lin,Qingzhe Wu et al.
Erica Yao et al.
Production of an appropriate number of distinct cell types in precise locations during embryonic development is critical for proper tissue function. Homeostatic renewal or repair of damaged tissues in adults also requires cell expansion and...
Long Noncoding RNA RP11-380D23.2 Drives Distal-Proximal Patterning of the Lung by Regulating PITX2 Expression [0.03%]
长非编码RNA RP11-380D23.2通过调节PITX2表达驱动肺的远端-近端模式化
Poulomi Banerjee,Harshini Surendran,Kapil Bharti et al.
Poulomi Banerjee et al.
Early lung development is a tightly orchestrated process encompassing (a) formation of definitive endoderm, (b) anteriorization of definitive endoderm, followed by (c) specification and maturation of both proximal and distal lung precursors...
Notch1 and Notch2 Coordinately Regulate Stem Cell Function in the Quiescent and Activated States of Muscle Satellite Cells [0.03%]
notch1和notch2协调调节肌肉卫星细胞静息态和激活态干细胞的功能
Shin Fujimaki,Daiki Seko,Yasuo Kitajima et al.
Shin Fujimaki et al.
Satellite cells, the muscle tissue stem cells, express three Notch receptors (Notch1-3). The function of Notch1 and Notch2 in satellite cells has to date not been fully evaluated. We investigated the role of Notch1 and Notch2 in myogenic pr...
Hematopoietic Substrate-1-Associated Protein X-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation [0.03%]
造血基质蛋白X-1通过调节Akt信号途径促进血管内皮祖细胞增殖和抑制其凋亡
Xin-Bin Guo,Xin Deng,Ying Wei
Xin-Bin Guo
Endothelial precursor cells (EPCs) are involved in vasculogenesis of various physiological and pathological processes. The proliferation and survival mechanism of EPCs needs to be explored further for the purpose of developing an effective ...
Single Cell Resolution of Human Hematoendothelial Cells Defines Transcriptional Signatures of Hemogenic Endothelium [0.03%]
人血细胞单细胞分辨率绘制造血内皮转录图谱
Mathew G Angelos,Juan E Abrahante,Robert H Blum et al.
Mathew G Angelos et al.
Endothelial-to-hematopoietic transition (EHT) is an important stage in definitive hematopoietic development. However, the genetic mechanisms underlying human EHT remain poorly characterized. We performed single cell RNA-seq using 55 hemogen...
Concise Review: Advanced Cell Culture Models for Diamond Blackfan Anemia and Other Erythroid Disorders [0.03%]
简评：用于钻石-布莱克泛贫血症和其他红细胞疾病的高度细胞培养模型
Anna Rita Migliaccio,Lilian Varricchio
Anna Rita Migliaccio
In vitro surrogate models of human erythropoiesis made many contributions to our understanding of the extrinsic and intrinsic regulation of this process in vivo and how they are altered in erythroid disorders. In the past, variability among...