Inflammatory Pathways and the Bone Marrow Microenvironment in Inherited Bone Marrow Failure Syndromes [0.03%]
炎症通路和先天性骨髓衰竭综合征的骨髓微环境
Nicholas Neoman,Hye Na Kim,Jacob Viduya et al.
Nicholas Neoman et al.
Inherited Bone Marrow Failure Syndromes (IBMFS) are a diverse group of genetic disorders characterized by insufficient hematopoietic cell production due to blood stem cell dysfunction. The most common syndromes are Fanconi Anemia, Diamond-B...
CD44: A Key Regulator of Iron Metabolism, Redox Balance, and Therapeutic Resistance in Cancer Stem Cells [0.03%]
CD44：癌症干细胞中铁代谢、氧化还原平衡和治疗耐药性的关键调节因子
Taiju Ando,Juntaro Yamasaki,Hideyuki Saya et al.
Taiju Ando et al.
CD44, a multifunctional cell surface protein, has emerged as a pivotal regulator in cancer stem cell (CSC) biology, orchestrating processes such as stemness, metabolic reprogramming, and therapeutic resistance. Recent studies have identifie...
Renal protective effects of extracellular vesicle-encapsulated tumor necrosis factor-α-induced protein 6 derived from mesenchymal stem cells [0.03%]
间充质干细胞衍生的肿瘤坏死因子-α诱导蛋白6包裹外泌体的肾保护作用
Keisuke Morimoto,Ayumu Nakashima,Naoki Ishiuchi et al.
Keisuke Morimoto et al.
Acute kidney injury (AKI) is involved in subsequent chronic kidney disease (CKD) development, and effective treatments to prevent AKI to CKD progression are lacking. Mesenchymal stem cells (MSCs) are emerging as a promising cellular therapy...
MSC-derived Exosomal miR-125b-5p Suppressed Retinal Microvascular Endothelial Cell Ferroptosis in Diabetic Retinopathy [0.03%]
外泌体miR-125b-5p通过抑制视网膜微血管内皮细胞铁死亡防治糖尿病视网膜病变
Jun Tong,Yueqin Chen,Xinru Ling et al.
Jun Tong et al.
Progressive endothelial cell injury of retinal vascular is a vital factor in diabetic retinopathy (DR) pathogenesis. Mesenchymal stem cells-derived small extracellular vesicles (MSC-sEVs) showed beneficial effects on DR. However, the effect...
Pdgfrβ marks distinct mesenchymal and pericyte populations within periosteum with overlapping cellular features [0.03%]
PDGFRβ标记具有重叠细胞特征的骨膜内不同间充质和周细胞群
Ziyi Wang,Qizhi Qin,Neelima Thottappillil et al.
Ziyi Wang et al.
Platelet derived growth factor receptor β (Pdgfrβ) is a cell surface marker often present on mesenchymal progenitor cells, playing a key role in regulating cell proliferation, migration, and survival. In the skeleton, Pdgfrβ-positive cel...
Newborn apical resection preserves the proliferative capacity of cardiomyocytes located throughout the left ventricle [0.03%]
新生儿心尖切除术保留左心室各区心肌细胞的增殖能力
Kaili Hao,Thanh Nguyen,Yuji Nakada et al.
Kaili Hao et al.
Background: When pigs underwent apical resection (AR) on postnatal day (P) 1 (ARP1) followed by myocardial infarction (MI) on P28, the hearts had little evidence of scarring; meanwhile, hearts underwent MI on P28 without ...
RUNX1 is a key inducer of human hematopoiesis controlling non-hematopoietic mesodermal development [0.03%]
RUNX1是调控非造血内胚层发育的人类造血诱导的关键因子
Zahir Shah,Cuihua Wang,Hanif Ullah et al.
Zahir Shah et al.
The RUNX1/AML1 transcription factor is one of the key regulators of definitive hematopoietic development in mice. However, its role in early human hematopoiesis remains poorly investigated. In this study, we integrated a tdTomato reporter c...
Impact of Pro-Inflammatory Cytokine Preconditioning on Metabolism and Extracellular Vesicles in Feline Mesenchymal Stromal Cells: A Preliminary Study [0.03%]
促炎症细胞因子预处理对猫间充质干细胞代谢和外泌体的影响：初步研究
Maria Soltero-Rivera,Boaz Arzi,Lynda Bourebaba et al.
Maria Soltero-Rivera et al.
Background: Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have shown promise in treating inflammation. This study investigates whether preconditioning feline adipose-derived stem cells (FeASCs) w...
Unlocking the potential of regionally-activated injury/ischemia-induced stem cells for neural regeneration [0.03%]
激活区域损伤/缺血诱导干细胞进行神经再生的潜力探讨
Takayuki Nakagomi
Takayuki Nakagomi
In the past, the mammal central nervous system (CNS) was assumed to lack the capacity for neural repair. However, increasing evidence shows that the CNS has repair capacity after injury. The migratory capacity of neural stem/progenitor cell...
ZIC1 transcription factor overexpression in segmental bone defects is associated with brown adipogenic and osteogenic differentiation [0.03%]
锌指蛋白C1转录因子在骨节段缺损中过表达与棕色脂肪形成和成骨分化有关
Neelima Thottappillil,Zhao Li,Xin Xing et al.
Neelima Thottappillil et al.
Transcriptional factor regulation is central to the lineage commitment of stem/ progenitor cells. ZIC1 (ZIC family member 1) is a C2H2-type zinc finger transcription factor expressed during development, brown fat, and certain cancers. Previ...