Metabolomic insights into associations between adiposity markers and liver cancer risk: Results from a prospective cohort study and Mendelian randomization analysis [0.03%]
基于前瞻性队列研究和孟德尔随机化分析的肥胖相关标志物与肝癌风险关联的代谢组学见解
Zhuo-Ying Li,Hong-Lan Li,Jing Wang et al.
Zhuo-Ying Li et al.
Background: The association between adiposity and increased liver cancer risk is well-recognized, yet underlying metabolic mechanisms require elucidation. This study aimed to identify metabolic mediators linking adiposity...
Leukemia in users of contemporary hormonal contraception: A nationwide registry-based cohort study among premenopausal women in Denmark [0.03%]
丹麦绝经前女性中现代激素避孕药使用者白血病风险的一项全国队列研究
Caroline H Hemmingsen,Susanne K Kjaer,Jasmin Arvedsen et al.
Caroline H Hemmingsen et al.
Background: Sex hormones have been implicated in leukemogenesis, but evidence regarding hormonal contraceptive use and leukemia risk remains limited and primarily based on older formulations. Given the widespread use of c...
Beyond the hype: Antibody-Drug Conjugates are advancing faster than our clinical strategy [0.03%]
拨开迷雾：抗体药物偶联物的临床策略需加速调整以应对ADC新进展
Giulia Notini,Giampaolo Bianchini,José Manuel Perez-Garcia et al.
Giulia Notini et al.
Antibody-drug conjugates are redefining treatment options in advanced breast cancer, demonstrating efficacy across all breast cancer subtypes. However, their rapid clinical expansion has resulted in several unresolved challenges, including ...
Intervention research to protect human health in the era of climate extremes [0.03%]
气候极端时代保护人类健康的介入研究
Till Bärnighausen,Helen Lumbard
Till Bärnighausen
Climate change is accelerating the frequency and severity of extreme weather events and increasingly threatening human health and life, particularly in low- and middle-income countries. Research on the effectiveness of climate adaptation in...
Pregnancy outcomes in women at high risk of preterm birth receiving a vaginal cervical cerclage with, or without, progesterone: A retrospective, secondary analysis of the C-STICH randomised controlled trial data [0.03%]
宫颈环扎术联合或不联合孕酮对预防预产期前分娩的孕妇的效果：来自C-STITCH随机对照试验的回顾性、二次分析数据
Victoria Hodgetts Morton,R Katie Morris,Philip Toozs-Hobson et al.
Victoria Hodgetts Morton et al.
Background: Vaginal cervical cerclage and progesterone are established treatments for prevention of pregnancy loss and prematurity. There is limited data to assess the effect of these treatments in combination. The object...
Correction: Sex-specific associations of adiposity with cardiometabolic traits in the UK: A multi-life stage cohort study with repeat metabolomics [0.03%]
纠正：在英国多生命周期队列研究中重复代谢组学与心血管代谢特征的性别差异关联性分析
Linda M O&#x;Keeffe,Joshua A Bell,Kate N O&#x;Neill et al.
Linda M O&#x;Keeffe et al.
[This corrects the article DOI: 10.1371/journal.pmed.1003636.]. Copyright: © 2026 O’Keeffe et al. This is an open access article distributed under the ...
Published Erratum
PLoS medicine. 2026 Jan 23;23(1):e1004901. DOI:10.1371/journal.pmed.1004901 2026
Psychological distress among Japanese high school students during the COVID-19 pandemic: An energy landscape analysis [0.03%]
新冠肺炎疫情期间日本高中生的心理压力：能量景观分析
Daiki Tatematsu,Naotoshi Nakamura,Masato S Abe et al.
Daiki Tatematsu et al.
Background: The stay-at-home orders, lockdowns, and states of emergency of the Coronavirus Infectious Disease emerged in 2019 (COVID-19) pandemic have affected the mental health of school-aged children. Previous reports o...
The benefits and risks of maternal RSV vaccination on mortality in South Africa: A modeling study [0.03%]
南非母体RSV免疫对婴儿死亡率的影响：基于模型的研究
Ayaka Monoi,Akira Endo,Simon R Procter et al.
Ayaka Monoi et al.
Background: Maternal respiratory syncytial virus (RSV) vaccine, RSV prefusion F protein vaccine (RSVpreF (Abrysvo)), was found to be safe and efficacious in the MATISSE trial. However, post-hoc stratified analyses identif...
Missing tissue, missing data: Resolving brain volume loss caused by anti-amyloid therapies [0.03%]
缺失的组织，缺失的数据：解决抗淀粉样蛋白治疗引起的脑体积损失问题
Francesca Alves,Scott Ayton
Francesca Alves
Anti-amyloid drugs modestly slow Alzheimer's disease progression, albeit with uncertainty of sustained benefit, particularly as they cause paradoxical acceleration of brain volume changes. Here, we examine explanations for these volume chan...
Glucagon-like peptide-1 receptor agonists for obesity: Growing popularity met with growing questions over safety [0.03%]
GLP-1受体激动剂治疗肥胖：日益流行的药物伴随着安全性的争议增加
Ariana M Chao,Adam Gilden,Thomas A Wadden
Ariana M Chao
Glucagon-like peptide-1 (GLP-1)-based medications, such as semaglutide and tirzepatide, have transformed obesity care. However, rising use brings concerns about side effects, long-term outcomes, and unregulated products. Ensuring safe acces...