Identification of lipid quantitative trait loci linked with cardiometabolic disease in Asian Indians and Europeans: A genome-wide association study and mendelian randomization [0.03%]
Madhusmita Rout,Christopher E Aston,Ravindranath Duggirala et al.
Madhusmita Rout et al.
Background: Genetic mechanisms that predispose people to type 2 diabetes (T2D) and cardiovascular disease (CVD) remain poorly understood, partly because of a lack of sufficient data on non-European ethnic groups. Extendin...
Quality of antenatal and delivery care and postnatal care use: A multi-country observational study of 400,000 births [0.03%]
Jan E Cooper,Hwa-Young Lee,Katherine Wright et al.
Jan E Cooper et al.
Background: Postnatal care (PNC) plays a crucial role in averting newborn mortality, yet its use remains low, particularly in regions with the highest mortality. While demographic and social determinants of PNC use have b...
Observational Study
PLoS medicine. 2026 Apr 21;23(4):e1005055. DOI:10.1371/journal.pmed.1005055 2026
Cost-effectiveness of esketamine versus alternative treatment strategies for treatment-resistant depression in Hong Kong: A multi-armed modeling study [0.03%]
香港难治性抑郁障碍患者使用右美沙朵治疗的成本效益多臂建模研究
Yifan Li,Vivien Kin Yi Chan,Mark Jit et al.
Yifan Li et al.
Background: Treatment-resistant depression (TRD), defined as failure to respond to at least two adequately administered antidepressant (AD) regimens, imposes major clinical and economic burdens. Esketamine nasal spray off...
Comparative Study
PLoS medicine. 2026 Apr 16;23(4):e1005047. DOI:10.1371/journal.pmed.1005047 2026
Rapid diagnostic tests, laboratory-based immunoassay and nucleic acid testing strategies for long-acting injectable pre-exposure prophylaxis: A systematic review and meta-analysis [0.03%]
长效注射式暴露前预防的快速检测试剂、实验室免疫检测及核酸测试策略：系统综述和meta分析
Warittha Tieosapjaroen,Eloise Williams,Cheryl C Johnson et al.
Warittha Tieosapjaroen et al.
Background: Long-acting injectable pre-exposure prophylaxis (LAI-PrEP) is a highly effective biomedical intervention for the prevention of HIV acquisition. There is a strong interest among communities and policymakers for...
Meta-Analysis
PLoS medicine. 2026 Apr 16;23(4):e1005030. DOI:10.1371/journal.pmed.1005030 2026
Association between gabapentinoid treatment, concurrent use with opioid or benzodiazepine and the risk of drug poisoning: A self-controlled case series study [0.03%]
钙离子通道调节剂的使用、与其他镇痛药联用及其导致药物中毒风险的关系：病例交叉研究
Andrew S C Yuen,Boqing Chen,Adrienne Y L Chan et al.
Andrew S C Yuen et al.
Background: Consumption of gabapentinoids has increased worldwide in recent years, and the association between its use and drug poisoning is of public health concern. This study aimed to investigate the association betwee...
Interpreting circulating microbiome-related metabolites in coronary heart disease [0.03%]
循环微生物相关代谢物与冠心病的关系及其机制研究
Zhonghan Sun,Mengkun Shi,Yan Zheng
Zhonghan Sun
Circulating microbiome-related metabolites have emerged as promising biomarkers for coronary heart disease. A recent multi-stage study in PLOS Medicine strengthens signal prioritization but highlights the persistent gap between association ...
Clostridioides difficile colonization amplification despite limited in-hospital transmission: A modeling study [0.03%]
一项建模研究：艰难梭菌定植增加与有限的院内传播之间的关系
Daniel De-la-Rosa-Martinez,Travis C Porco,Ashley Hazel et al.
Daniel De-la-Rosa-Martinez et al.
Background: Although healthcare-associated transmission of Clostridioides difficile is a recognized public health concern, community-onset infections represent an important component of the overall disease burden. This pa...
Correction: Quantify unmet medical need across the disease landscape - A large language model-based methodology [0.03%]
纠正：量化整个疾病谱系中的未满足医疗需求——一种基于大型语言模型的方法学
Elliott W Sharp,Nicholas Fragola,Charlotte Blewitt et al.
Elliott W Sharp et al.
[This corrects the article DOI: 10.1371/journal.pmed.1004798.]. Copyright: © 2026 Sharp et al. This is an open access article distributed under the term...
Published Erratum
PLoS medicine. 2026 Apr 10;23(4):e1005048. DOI:10.1371/journal.pmed.1005048 2026
Association between early methadone dose titration and treatment discontinuation and opioid toxicity: A retrospective cohort study [0.03%]
早期美沙酮剂量滴定与治疗中断和阿片类药物中毒之间的关联：一项回顾性队列研究
Ria Garg,Jin Luo,Nikki Bozinoff et al.
Ria Garg et al.
Background: Clinical guidance in Canada and the United States recommends faster methadone dose titration for individuals using fentanyl. An initial dose increase is recommended between days 4 and 6, but the impact on pati...
Nic G Reitsam
Nic G Reitsam
Integrating spatial omics with artificial intelligence is likely to advance biomarker research and diagnostics, with the potential to pair mechanistic insight into spatial target biology. By developing scalable, reproducible quantification ...