Photoacoustic imaging of metabolic activities across biological length scales [0.03%]
跨生物尺度的代谢活动的光声成像技术
Gabriella Mankovskii,Eno Hysi
Gabriella Mankovskii
Imaging is ubiquitous with biomedical research and discovery. This article surveys the role of imaging in our understanding of metabolism, and introduces photoacoustic imaging as a compelling candidate for providing high-resolution, label-f...
Neural Circuits of Fear and Anxiety: Insights from a Neuroethological Perspective [0.03%]
恐惧与焦虑的神经环路：来自神经行为学的见解
Fernando Falkenburguer Melleu,Newton Sabino Canteras
Fernando Falkenburguer Melleu
The predatory imminence continuum (PIC) of antipredator defensive behavior has been a helpful strategy for modeling anxiety and fear-related disorders in nonclinical research. The PIC is divided into three different sequential stages that r...
Nikki Forrester
Nikki Forrester
Timo van Hattem,Lieuwe Verkaar,Elena Krugliakova et al.
Timo van Hattem et al.
Sleep has been postulated to play an important role in the removal of potentially neurotoxic molecules, such as amyloid-β, from the brain via the glymphatic system. Disturbed sleep, on the other hand, may contribute to the accumulation of ...
A Multiscale Perspective on Chromatin Architecture through Polymer Physics [0.03%]
通过聚合物物理从多尺度角度看待染色质结构
Francesca Vercellone,Andrea M Chiariello,Andrea Esposito et al.
Francesca Vercellone et al.
The spatial organization of chromatin within the eukaryotic nucleus is critical in regulating key cellular functions, such as gene expression, and its disruption can lead to disease. Advances in experimental techniques, such as Hi-C and mic...
Omar A Hafez,Rui B Chang
Omar A Hafez
The autonomic nervous system is critical for regulating cardiovascular physiology. The neurocardiac axis encompasses multiple levels of control, including the motor circuits of the sympathetic and parasympathetic nervous systems, sensory ne...
Sarah J Meller,Charles A Greer
Sarah J Meller
Olfactory deficits are increasingly recognized in a variety of neurological, neurodevelopmental, psychiatric, and viral diseases. While the pathology underlying olfactory loss is likely to differ across diseases, one shared feature may be a...
Jenna G Connolly,Leigh D Plant
Jenna G Connolly
The small ubiquitin-like modifier (SUMO) protein pathway governs a panoply of vital biological processes including cell death, proliferation, differentiation, metabolism, and signal transduction by diversifying the functions, half-lives, an...
mTORC1 and 2 adrenergic regulation and function in brown adipose tissue [0.03%]
棕色脂肪组织中mTORC1和mTORC2的肾上腺素调节与功能
William T Festuccia
William T Festuccia
Brown adipose tissue (BAT) thermogenesis results from the uncoupling of mitochondrial inner membrane proton gradient mediated by the uncoupling protein 1 (UCP-1), which is activated by lipolysis-derived fatty acids. Norepinephrine (NE) secr...
Somaya Y Ibrahim,Jayden Carter,Rushita A Bagchi
Somaya Y Ibrahim
Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl groups from key lysine residues on histone and non-histone proteins and thereby regulate gene transcription. They have been implicated in several biological proces...