The roles of CaMKII and F-actin in the structural plasticity of dendritic spines: a potential molecular identity of a synaptic tag? [0.03%]
钙调神经磷酸酶Ⅱ和F肌动蛋白在树突棘结构可塑性中的作用：突触标记的潜在分子标志物？
Kenichi Okamoto,Miquel Bosch,Yasunori Hayashi
Kenichi Okamoto
Ca2+/calmodulin-dependent protein kinase II (CaMKII) and actin are two crucial molecules involved in long-term potentiation (LTP). In addition to its signaling function, CaMKII plays a structural role via direct interaction with actin filam...
Sandra Puetz,Lubomir T Lubomirov,Gabriele Pfitzer
Sandra Puetz
Next to changes in cytosolic [Ca(2+)], members of the Rho subfamily of small GTPases, in particular Rho and its effector Rho kinase, also known as ROK or ROCK, emerged as key regulators of smooth muscle function in health and disease. In th...
Roles of phospholipase C isozymes in organogenesis and embryonic development [0.03%]
磷脂酶C同工酶在器官发生和胚胎发育中的作用
Yoshikazu Nakamura,Kiyoko Fukami
Yoshikazu Nakamura
Phosphoinositide metabolism is an important intracellular signaling system that regulates a variety of cellular functions. Phospholipase C (PLC) is a key enzyme in this system. Recent studies on genetically manipulated mice have clarified t...
Marc Y Donath,Marianne Böni-Schnetzler,Helga Ellingsgaard et al.
Marc Y Donath et al.
Onset of Type 2 diabetes occurs when the pancreatic beta-cell fails to adapt to the increased insulin demand caused by insulin resistance. Morphological and therapeutic intervention studies have uncovered an inflammatory process in islets o...
The International Union of Physiological Sciences. IUPS Editorial VIII [0.03%]
国际生理科学联合会(IUPS)第八届编辑委员会
Ole H Petersen
Ole H Petersen
HIF2α: the interface between oxygen-sensing systems in physiology and pathology [0.03%]
HIF2α：生理和病理氧传感系统的介面
More than 100 years after the original descriptions of altitude adaptation, it is now clear that many of these responses are mediated by a specific isoform of the transcription factor hypoxia-inducible factor (HIF-2α). Here, we review this...