Voltage-gated proton channels find their dream job managing the respiratory burst in phagocytes [0.03%]
电压门控质子通道在好氧噬细胞呼吸爆发中的理想工作
Thomas E DeCoursey
Thomas E DeCoursey
The voltage-gated proton channel bears surprising resemblance to the voltage-sensing domain (S1-S4) of other voltage-gated ion channels but is a dimer with two conduction pathways. The proton channel seems designed for efficient proton extr...
Steve Terry,Mei Nie,Karl Matter et al.
Steve Terry et al.
Tight junctions are heteromeric protein complexes that act as signaling centers by mediating the bidirectional transmission of information between the environment and the cell interior to control paracellular permeability and differentiatio...
Brian M Kevany,Krzysztof Palczewski
Brian M Kevany
Photoreceptor cells maintain a roughly constant length by continuously generating new outer segments from their base while simultaneously releasing mature outer segments engulfed by the retinal pigment epithelium (RPE). Thus postmitotic RPE...
Walter F Boron
Walter F Boron
The rocking bundle: a mechanism for ion-coupled solute flux by symmetrical transporters [0.03%]
离子耦合溶质通量的摇摆机制：对称转运蛋白研究
Lucy R Forrest,Gary Rudnick
Lucy R Forrest
Crystal structures of the bacterial amino acid transporter LeuT have provided the basis for understanding the conformational changes associated with substrate translocation by a multitude of transport proteins with the same fold. Biochemica...
Functional organization of the porosome complex and associated structures facilitating cellular secretion [0.03%]
细胞分泌所必需的胞分泌颗粒复合物及相关的功能结构
Bhanu P Jena
Bhanu P Jena
Porosomes, the universal secretory machinery at the cell plasma membrane, are cup-shaped supramolecular lipoprotein structures, where membrane-bound vesicles transiently dock and fuse to release intravesicular contents during cell secretion...
The roles of CaMKII and F-actin in the structural plasticity of dendritic spines: a potential molecular identity of a synaptic tag? [0.03%]
钙调神经磷酸酶Ⅱ和F肌动蛋白在树突棘结构可塑性中的作用：突触标记的潜在分子标志物？
Kenichi Okamoto,Miquel Bosch,Yasunori Hayashi
Kenichi Okamoto
Ca2+/calmodulin-dependent protein kinase II (CaMKII) and actin are two crucial molecules involved in long-term potentiation (LTP). In addition to its signaling function, CaMKII plays a structural role via direct interaction with actin filam...
Sandra Puetz,Lubomir T Lubomirov,Gabriele Pfitzer
Sandra Puetz
Next to changes in cytosolic [Ca(2+)], members of the Rho subfamily of small GTPases, in particular Rho and its effector Rho kinase, also known as ROK or ROCK, emerged as key regulators of smooth muscle function in health and disease. In th...
Roles of phospholipase C isozymes in organogenesis and embryonic development [0.03%]
磷脂酶C同工酶在器官发生和胚胎发育中的作用
Yoshikazu Nakamura,Kiyoko Fukami
Yoshikazu Nakamura
Phosphoinositide metabolism is an important intracellular signaling system that regulates a variety of cellular functions. Phospholipase C (PLC) is a key enzyme in this system. Recent studies on genetically manipulated mice have clarified t...
Marc Y Donath,Marianne Böni-Schnetzler,Helga Ellingsgaard et al.
Marc Y Donath et al.
Onset of Type 2 diabetes occurs when the pancreatic beta-cell fails to adapt to the increased insulin demand caused by insulin resistance. Morphological and therapeutic intervention studies have uncovered an inflammatory process in islets o...