Pulmonary surfactant pathophysiology: current models and open questions [0.03%]
肺表面活性物质的病理生理学：现有模型和开放性问题
Jesús Perez-Gil,Timothy E Weaver
Jesús Perez-Gil
Pulmonary surfactant is an essential lipid-protein complex that stabilizes the respiratory units (alveoli) involved in gas exchange. Quantitative or qualitative derangements in surfactant are associated with severe respiratory pathologies. ...
Denis Noble
Denis Noble
Membrane protein clusters at nanoscale resolution: more than pretty pictures [0.03%]
纳米尺度分辨率下的膜蛋白聚集体：不仅仅是美丽的图像
Thorsten Lang,Silvio O Rizzoli
Thorsten Lang
Fluorescence microscopy is powerful for analyzing the composition and dynamics of cellular elements, but studying precise molecule patterns is precluded due to diffraction limited resolution. This barrier has been lifted now through several...
Emma J Parkinson-Lawrence,Tetyana Shandala,Mark Prodoehl et al.
Emma J Parkinson-Lawrence et al.
The discovery over five decades ago of the lysosome, as a degradative organelle and its dysfunction in lysosomal storage disorder patients, was both insightful and simple in concept. Here, we review some of the history and pathophysiology o...
Esther Witsch,Michael Sela,Yosef Yarden
Esther Witsch
Under physiological conditions, cells receive fate-determining signals from their tissue surroundings, primarily in the form of polypeptide growth factors. Integration of these extracellular signals underlies tissue homeostasis. Although de...
Lessons from photoreceptors: turning off g-protein signaling in living cells [0.03%]
视杆细胞的启示：在活细胞中关闭G蛋白信号通道的方法
Marie E Burns,Edward N Pugh Jr
Marie E Burns
Phototransduction in retinal rods is one of the most extensively studied G-protein signaling systems. In recent years, our understanding of the biochemical steps that regulate the deactivation of the rod's response to light has greatly impr...
Biological roles of Acid and neutral sphingomyelinases and their regulation by nitric oxide [0.03%]
酸性和中性丝氨酸磷酸酶的生物学作用及其一氧化氮介导的调节机制
Cristiana Perrotta,Emilio Clementi
Cristiana Perrotta
Generation of the pleiotropic sphingolipid mediator ceramide by acid and neutral sphingomyelinases is a key event in many cellular pathophysiological processes including survival, death, proliferation, and differentiation, in which also the...
Michael Caplan
Michael Caplan
Frederick Sachs
Frederick Sachs
Mechanosensitive ion channels (MSCs) exist in all cells, but mechanosensitivity is a phenotype not a genotype. Specialized mechanoreceptors such as the hair cells of the cochlea require elaborate mechanical impedance matching to couple the ...
Susumu Tomita
Susumu Tomita
Glutamate receptors are major excitatory receptors in the brain. Recent findings have established auxiliary subunits of glutamate receptors as critical modulators of synaptic transmission, synaptic plasticity, and neurological disorder. The...