Helle H Damkier,Peter D Brown,Jeppe Praetorius
Helle H Damkier
A stable intraventricular milieu is crucial for maintaining normal neuronal function. The choroid plexus epithelium produces the cerebrospinal fluid and in doing so influences the chemical composition of the interstitial fluid of the brain....
A El Manira,A Kyriakatos
A El Manira
Cannabinoid receptors and endocannabinoid signaling are distributed throughout the rostrocaudal neuraxis. Retrograde signaling via endocannabinoid mediates synaptic plasticity in many regions in the central nervous system. Here, we review t...
Amanda C Stanley,Paige Lacy
Amanda C Stanley
Cytokine secretion is a widely studied process, although little is known regarding the specific mechanisms that regulate cytokine release. Recent findings have shed light on some of the precise molecular pathways that regulate the packaging...
Xavier d&#x;Anglemont de Tassigny,William Henry Colledge
Xavier d&#x;Anglemont de Tassigny
Kisspeptins are a group of peptides that stimulate GnRH release and are required for puberty and maintenance of normal reproductive function. This review focuses on our understanding of the way in which kisspeptin signaling regulates mammal...
Walter F Boron
Walter F Boron
The giant protein titin as an integrator of myocyte signaling pathways [0.03%]
超大分子蛋白Titin在心肌细胞信号转导通路中的整合作用
Wolfgang A Linke,Martina Krüger
Wolfgang A Linke
The giant muscle protein titin, the "backbone" of the sarcomere, harbors a complex molecular spring whose stiffness is variably tuned in health and disease. Titin is increasingly recognized as a crucial integrator of diverse myocyte signali...
PPAR modulation of kinase-linked receptor signaling in physiology and disease [0.03%]
PPAR与激酶偶联受体信号通路在生理和病理中的作用
Nicolas Rotman,Walter Wahli
Nicolas Rotman
Kinase-linked receptors and nuclear receptors connect external cues to gene transcription. Among nuclear receptors, peroxisome proliferator-activated receptors (PPARs) are of special interest in relation to widespread human diseases. Mappin...
Calcium signaling through CatSper channels in mammalian fertilization [0.03%]
哺乳动物受精过程中CatSper通道介导的钙信号转导
Dejian Ren,Jingsheng Xia
Dejian Ren
The molecular mechanisms underlying Ca(2+) entry into sperm are now much more well defined thanks to direct recordings of mature sperm cells. This article reviews the function of a sperm-specific ion channel, CatSper. CatSpers have a clearl...
Physiological roles of the TRPM4 channel extracted from background currents [0.03%]
从背景电流中提取的TRPM4通道的生理作用
Romain Guinamard,Marie Demion,Pierre Launay
Romain Guinamard
Calcium-activated nonselective cationic currents have been known for 30 years, but their physiological implications have remained unresolved until the recent cloning of the TRPM4 ion channel. Since then, TRPM4 has been identified as a key m...
Yi Wang,Saher A Shaikh,Emad Tajkhorshid
Yi Wang
Transmembrane exchange of materials is a fundamental process in biology. Molecular dynamics provides a powerful method to investigate in great detail various aspects of the phenomenon, particularly the permeation of small uncharged molecule...