Promoting a central role for physiology in research and education worldwide [0.03%]
在全球范围内促进生理学在科研和教育中发挥核心作用
Gary Sieck,Peter Wagner,Joey Granger
Gary Sieck
Laura Lee Colgin,Edvard I Moser
Laura Lee Colgin
Gamma oscillations are thought to temporally link the activity of distributed cells. We discuss mechanisms of gamma oscillations in the hippocampus and review evidence supporting a functional role for such oscillations in several key hippoc...
Amber E Hudson,Santiago Archila,Astrid A Prinz
Amber E Hudson
Neural circuits rely on slight physiological differences between the component cells for proper function. When any circuit is analyzed, it is important to characterize the features that distinguish one cell type from another. This review de...
Coen A C Ottenheijm,Henk Granzier
Coen A C Ottenheijm
Nebulin is a giant protein and a constituent of the skeletal muscle sarcomere. The name of this protein refers to its unknown (i.e., nebulous) function. However, recent rapid advances reveal that nebulin plays important roles in the regulat...
Energy landscapes as a tool to integrate GPCR structure, dynamics, and function [0.03%]
运用GPCR能量景观整合受体结构、动态及功能研究
Xavier Deupi,Brian K Kobilka
Xavier Deupi
G protein-coupled receptors (GPCRs) are versatile signaling molecules that mediate the majority of physiological responses to hormones and neurotransmitters. Recent high-resolution structural insights into GPCR structure and dynamics are be...
Sorting it out in endosomes: an emerging concept in renal epithelial cell transport regulation [0.03%]
肾上皮细胞转运调节中的新兴概念：溶酶体内部分 Sorting it out in endosomes
Paul A Welling,Ora A Weisz
Paul A Welling
Ion and water transport by the kidney is continually adjusted in response to physiological cues. Selective endocytosis and endosomal trafficking of ion transporters are increasingly appreciated as mechanisms to acutely modulate renal functi...
Ancient atmospheres and the evolution of oxygen sensing via the hypoxia-inducible factor in metazoans [0.03%]
原核生物中古大气及多细胞生物通过缺氧诱导因子来进化感受氧气
Cormac T Taylor,Jennifer C McElwain
Cormac T Taylor
Metazoan diversification occurred during a time when atmospheric oxygen levels fluctuated between 15 and 30%. The hypoxia-inducible factor (HIF) is a primary regulator of the adaptive transcriptional response to hypoxia. Although the HIF pa...
Translation to the public [0.03%]
公之于众
Ulrich Pohl
Ulrich Pohl
A gene for speed: the emerging role of alpha-actinin-3 in muscle metabolism [0.03%]
速度基因：α-actinin-3在肌肉代谢中的作用不容小觑
Yemima Berman,Kathryn N North
Yemima Berman
A common polymorphism (R577X) in the ACTN3 gene results in complete deficiency of alpha-actinin-3 protein in approximately 16% of humans worldwide. The presence of alpha-actinin-3 protein is associated with improved sprint/power performance...