Spontaneous neurotransmission: an independent pathway for neuronal signaling? [0.03%]
自发性神经递质释放：独立的神经信号传导途径？
Ege T Kavalali,Chihye Chung,Mikhail Khvotchev et al.
Ege T Kavalali et al.
Recent findings suggest that spontaneous neurotransmission is a bona fide pathway for interneuronal signaling that operates independent of evoked transmission via distinct presynaptic as well as postsynaptic substrates. This article will ex...
Regulated intramembrane proteolysis: signaling pathways and biological functions [0.03%]
调控胞内蛋白酶切：信号转导和生物学功能
Mark Lal,Michael Caplan
Mark Lal
Intramembrane cleavage of transmembrane proteins is a fundamental cellular process. Several enzymes capable of releasing domains of integral membrane proteins have been described. Transmembrane protein proteolytic cleavage is regulated and ...
Protein kinase D signaling: multiple biological functions in health and disease [0.03%]
蛋白激酶D信号转导：生理与疾病中的多种生物学功能
Enrique Rozengurt
Enrique Rozengurt
Protein kinase D (PKD) is an evolutionarily conserved protein kinase family with structural, enzymological, and regulatory properties different from the PKC family members. Signaling through PKD is induced by a remarkable number of stimuli,...
Ken Abe,Rosa Puertollano
Ken Abe
Some members of the transient receptor potential (TRP) channel superfamily have proved to be essential in maintaining adequate ion homeostasis, signaling, and membrane trafficking in the endosomal pathway. The unique properties of the TRP c...
Yasushi Okamura,Jack E Dixon
Yasushi Okamura
Voltage-sensing phosphoinositide phosphatase (VSP) contains voltage sensor and cytoplasmic phosphatase domains. A unique feature of this protein is that depolarization-induced motions of the voltage sensor activate PtdIns(3,4,5)P(3) and Ptd...
Walter F Boron
Walter F Boron
Catriona M H Anderson,David T Thwaites
Catriona M H Anderson
The physiological role of mammalian solute carrier (SLC) proteins is to mediate transmembrane movement of electrolytes, nutrients, micronutrients, vitamins, and endogenous metabolites from one cellular compartment to another. Many transport...
Loretta Ferrera,Antonella Caputo,Luis J V Galietta
Loretta Ferrera
Ca(+)-dependent Cl⁻ channels (CaCCs) play a variety of physiological roles in different organs and tissues, including transepithelial Cl⁻ secretion, smooth muscle contraction, regulation of neuronal excitability, and transduction of senso...
Peroxisome biogenesis: something old, something new, something borrowed [0.03%]
过氧化物酶体生物发生：承旧启新取它山之石
Fred D Mast,Andrei Fagarasanu,Barbara Knoblach et al.
Fred D Mast et al.
Eukaryotic cells are characterized by their varied complement of organelles. One set of membrane-bound, usually spherical compartments are commonly grouped together under the term peroxisomes. Peroxisomes function in regulating the synthesi...
Germain U Busto,Isaac Cervantes-Sandoval,Ronald L Davis
Germain U Busto
Studies of olfactory learning in Drosophila have provided key insights into the brain mechanisms underlying learning and memory. One type of olfactory learning, olfactory classical conditioning, consists of learning the contingency between ...