Mathias Francois,Natasha L Harvey,Benjamin M Hogan
Mathias Francois
More than 100 years ago, Florence Sabin suggested that lymphatic vessels develop by sprouting from preexisting blood vessels, but it is only over the past decade that the molecular mechanisms underpinning lymphatic vascular development have...
Vascular effects of exercise: endothelial adaptations beyond active muscle beds [0.03%]
运动的血管效应：肌外内皮适应性反应
Jaume Padilla,Grant H Simmons,Shawn B Bender et al.
Jaume Padilla et al.
Endothelial adaptations to exercise training are not exclusively conferred within the active muscle beds. Herein, we summarize key studies that have evaluated the impact of chronic exercise on the endothelium of vasculatures perfusing nonwo...
Systems: What's in a name? [0.03%]
系统之名的意义何在？
Denis Noble
Denis Noble
Aldosterone paradox: differential regulation of ion transport in distal nephron [0.03%]
醛固酮悖论：远端肾小管离子转运的差异调节机制
Juan Pablo Arroyo,Caroline Ronzaud,Dagmara Lagnaz et al.
Juan Pablo Arroyo et al.
The mechanisms through which aldosterone promotes apparently opposite effects like salt reabsorption and K(+) secretion remain poorly understood. The identification, localization, and physiological analysis of ion transport systems in dista...
Sarah B Scruggs,Peipei Ping,Chenggong Zong
Sarah B Scruggs
Proteasome biology has taken central stage in cardiac physiology and pathophysiology. The molecular heterogeneity of proteasome subpopulations supports the specificity of proteasome function to degrade diverse substrate repertoires. Unveili...
The athlete's heart vs. the failing heart: can signaling explain the two distinct outcomes? [0.03%]
运动员心脏与衰竭心脏的区别：信号传导可以解释两种不同的结果吗？
Kate L Weeks,Julie R McMullen
Kate L Weeks
Cardiac remodeling is typically associated with disease and can lead to heart failure. In contrast, remodeling that occurs in the athlete's heart is considered an adaptive physiological response. This review provides an overview of signalin...
mTor signaling in skeletal muscle during sepsis and inflammation: where does it all go wrong? [0.03%]
感染和炎症期间骨骼肌中的mTOR信号：它出了什么问题？
Robert A Frost,Charles H Lang
Robert A Frost
The mammalian target of rapamycin (mTOR) is an evolutionarily conserved protein kinase that exquisitely regulates protein metabolism in skeletal muscle. mTOR integrates input from amino acids, growth factors, and intracellular cues to make ...
Endocannabinoids and motor behavior: CB1 receptors also control running activity [0.03%]
内源大麻素与运动行为的关系：CB1受体也控制运行活性
Francis Chaouloff,Sarah Dubreucq,Luigi Bellocchio et al.
Francis Chaouloff et al.
Michael J Joyner
Michael J Joyner
Oxidative stress and cell membranes in the pathogenesis of Alzheimer's disease [0.03%]
氧化应激和细胞膜在阿尔茨海默病发病机制中的作用
Paul H Axelsen,Hiroaki Komatsu,Ian V J Murray
Paul H Axelsen
Amyloid β proteins and oxidative stress are believed to have central roles in the development of Alzheimer's disease. Lipid membranes are among the most vulnerable cellular components to oxidative stress, and membranes in susceptible regio...