Ramón Latorre,Sebastián Brauchi,Rodolfo Madrid et al.
Ramón Latorre et al.
Transient receptor potential melastatin 8 (TRPM8), a calcium-permeable cation channel activated by cold, cooling compounds and voltage, is the main molecular entity responsible for detection of cold temperatures in the somatosensory system....
Qais Al-Awqati,Xaio Bo Gao
Qais Al-Awqati
The intercalated cell of collecting ducts of the kidney is of two forms, the α form secretes acid, whereas the β form secretes HCO(3). Here, we review recent work that shows that the α form is derived from the β form and that the pathwa...
Maike Glitsch
Maike Glitsch
Ion channels and G-protein-coupled receptors (GPCRs) play a fundamental role in cancer progression by influencing Ca(2+) influx and signaling pathways in transformed cells. Transformed cells thrive in a hostile environment that is character...
Muthukumar Balasubramaniam,Eric O Freed
Muthukumar Balasubramaniam
Assembly and release of human immunodeficiency virus type 1 (HIV-1) particles is mediated by the viral Gag polyprotein precursor. Gag is synthesized in the cytosol and rapidly translocates to membrane to orchestrate particle production. The...
Oren Froy
Oren Froy
Resetting the circadian clock leads to well being and increased life span, whereas clock disruption is associated with aging and morbidity. Increased longevity and improved health can be achieved by different feeding regimens that reset cir...
Carles Cantó,Johan Auwerx
Carles Cantó
Dietary restriction can extend life span in most organisms tested to date, suggesting that mechanisms sensing nutrient and energy availability might regulate longevity. The AMP-activated protein kinase (AMPK) has emerged as a key energy sen...
Ajit S Divakaruni,Martin D Brand
Ajit S Divakaruni
Mitochondria couple respiration to ATP synthesis through an electrochemical proton gradient. Proton leak across the inner membrane allows adjustment of the coupling efficiency. The aim of this review is threefold: 1) introduce the unfamilia...
Membrane proteins as 14-3-3 clients in functional regulation and intracellular transport [0.03%]
膜蛋白作为14-3-3结合蛋白在功能调节和胞内运输中的作用
Andrew J Smith,Jürgen Daut,Blanche Schwappach
Andrew J Smith
14-3-3 proteins regulate the function and subcellular sorting of membrane proteins. Often, 14-3-3 binding to client proteins requires phosphorylation of the client, but the relevant kinase is unknown in most cases. We summarize current prog...
Cell polarity and migration: emerging role for the endosomal sorting machinery [0.03%]
胞质极性与迁移：内涵体分选装置的新兴作用机制
Viola Hélène Lobert,Harald Stenmark
Viola Hélène Lobert
The endosomal sorting complex required for transport (ESCRT) machinery has been implicated in the regulation of endosomal sorting, cell division, viral budding, autophagy, and cell signaling. Here, we review recent evidence that implicates ...
Regulation of smooth muscle contraction by the epithelium: role of prostaglandins [0.03%]
上皮对平滑肌收缩的调节作用：前列腺素的作用
Ye Chun Ruan,Wenliang Zhou,Hsiao Chang Chan
Ye Chun Ruan
As an analog to the endothelium situated next to the vascular smooth muscle, the epithelium is emerging as an important regulator of smooth muscle contraction in many vital organs/tissues by interacting with other cell types and releasing e...