Ulrich Pohl
Ulrich Pohl
Haipeng Sun,Yibin Wang
Haipeng Sun
Cell death is regulated by a myriad of intracellular molecular pathways, with many involving protein phosphorylation and dephosphorylation. In this review, we will focus on Ser/Thr phosphatases-mediated regulation in cell apoptosis as well ...
Lifeng Pan,Mingjie Zhang
Lifeng Pan
Usher syndrome 1 (USH1) is the most common and severe form of hereditary loss of hearing and vision. Genetic, physiological, and cell biological studies, together with recent structural investigations, have not only uncovered the physiologi...
Pablo Ariel,Timothy A Ryan
Pablo Ariel
The strength of a synapse can profoundly influence network function. How this strength is set at the molecular level is a key question in neuroscience. Here, we review a simple model of neurotransmission that serves as a convenient framewor...
Slc13a1 and Slc26a1 KO models reveal physiological roles of anion transporters [0.03%]
Slc13a1和Slc26a1敲除小鼠揭示了伴氯阴离子转运体的生理功能
Daniel Markovich
Daniel Markovich
Anion transporters NaS1 (SLC13A1) and Sat1 (SLC26A1) mediate sulfate (re)absorption across renal proximal tubule and small intestinal epithelia, thereby regulating blood sulfate levels. Disruption of murine NaS1 and Sat1 genes leads to hypo...
Physiology without borders 2 [0.03%]
无国界生理学2
Denis Noble,Yoshihisa Kurachi,Peter Hunter et al.
Denis Noble et al.
Florian Lesage,Jacques Barhanin
Florian Lesage
Background K(2P) channels are tightly regulated by different stimuli including variations of external and internal pH. pH sensitivity relies on proton-sensing residues that influence channel gating and activity. Gene inactivation in the mou...
Social regulation of gene expression in the hypothalamic-pituitary-gonadal axis [0.03%]
社会调节基因在下丘脑-垂体-性腺轴中的表达机制
Karen P Maruska,Russell D Fernald
Karen P Maruska
Reproduction is a critically important event in every animals' life and in all vertebrates is controlled by the brain via the hypothalamic-pituitary-gonadal (HPG) axis. In many species, this axis, and hence reproductive fitness, can be prof...
Gareth B Miles,Keith T Sillar
Gareth B Miles
Vertebrate locomotion must be adaptable in light of changing environmental, organismal, and developmental demands. Much of the underlying flexibility in the output of central pattern generating (CPG) networks of the spinal cord and brain st...
Water in a crowd [0.03%]
人群中的一股清流
Michael D Fayer
Michael D Fayer
In many situations, form biology to geology, water occurs not as the pure bulk liquid but rather in nanoscopic environments, in contact with interfaces, interacting with ionic species, and interacting with large organic molecules. In such s...