Amy L Eastwood,Miriam B Goodman
Amy L Eastwood
The founding members of the superfamily of DEG/ENaC ion channel proteins are C. elegans proteins that form mechanosensitive channels in touch and pain receptors. For more than a decade, the research community has used mutagenesis to identif...
Dietmar Kültz
Dietmar Kültz
Organisms exposed to altered salinity must be able to perceive osmolality change because metabolism has evolved to function optimally at specific intracellular ionic strength and composition. Such osmosensing comprises a complex physiologic...
Dong I Lee,David A Kass
Dong I Lee
The cyclic nucleotide cGMP and its corresponding activated kinase cGK-1 serve as a counterbalance to acute and chronic myocardial stress. cGMP hydrolysis by several members of the phosphodiesterase (PDE) superfamily, PDE1, PDE2, and PDE5, r...
Cathryn M Kolka,Richard N Bergman
Cathryn M Kolka
Hormones are involved in a plethora of processes including development and growth, metabolism, mood, and immune responses. These essential functions are dependent on the ability of the hormone to access its target tissue. In the case of end...
Erik I Christensen,Henrik Birn,Tina Storm et al.
Erik I Christensen et al.
Protein reabsorption is a predominant feature of the renal proximal tubule. Animal studies show that the ability to rescue plasma proteins relies on the endocytic receptors megalin and cubilin. Recently, studies of patients with syndromes c...
Michael Simons
Michael Simons
Vascular endothelial growth factors (VEGF) and their receptors play a central role in the development of cardiovascular system and in vasculature-related processes in the adult organism. Given the critical role of this signaling cascade, in...
Claudia Lodovichi,Leonardo Belluscio
Claudia Lodovichi
In mammals, smell is mediated by odorant receptors expressed by sensory neurons in the nose. These specialized receptors are found both on olfactory sensory neurons' cilia and axon terminals. Although the primary function of ciliary odorant...
Optimizing cholinergic tone through lynx modulators of nicotinic receptors: implications for plasticity and nicotine addiction [0.03%]
通过烟碱受体lynx调制剂优化胆碱张力：突触可塑性和尼古丁成瘾的启示
Julie M Miwa,Henry A Lester,Andreas Walz
Julie M Miwa
The cholinergic system underlies both adaptive (learning and memory) and nonadaptive (addiction and dependency) behavioral changes through its ability to shape and regulate plasticity. Protein modulators such as lynx family members can fine...
Gary C Sieck
Gary C Sieck