Denis Noble
Denis Noble
Sandra C Garrett,Joshua J C Rosenthal
Sandra C Garrett
A-to-I RNA editing can recode mRNAs, giving organisms the option to express diverse, functionally distinct protein isoforms. Here, we propose that RNA editing is inherently geared for temperature adaptation because it tends to recode to sma...
Kang-Yang Jih,Tzyh-Chang Hwang
Kang-Yang Jih
Malfunction of cystic fibrosis transmembrane conductance regulator (CFTR), a member of the ABC protein superfamily that functions as an ATP-gated chloride channel, causes the lethal genetic disease, cystic fibrosis. This review focuses on t...
Roles for the sarco-/endoplasmic reticulum in cardiac myocyte contraction, protein synthesis, and protein quality control [0.03%]
浅析肌浆/内质网在心室肌细胞收缩、蛋白质合成及蛋白质量控制中的作用
Christopher C Glembotski
Christopher C Glembotski
Although the function of the sarcoplasmic/endoplasmic reticulum (SR/ER) in cardiac contractile calcium handling is well established, its roles in protein synthesis, folding, and quality control in cardiac myocytes are not as clear. This rev...
Themes and variations in ER/SR calcium release channels: structure and function [0.03%]
内质网/肌浆网钙释放通道的结构与功能及其异同点：主题和变化
Peter B Stathopulos,Min-duk Seo,Masahiro Enomoto et al.
Peter B Stathopulos et al.
Calcium (Ca(2+)) release from reticular stores is a vital regulatory signal in eukaryotes. Recent structural data on large NH(2)-terminal regions of IP(3)Rs and RyRs and their tetrameric arrangement in the full-length context reveal strikin...
Design principles for life [0.03%]
生命的设计原则
Gary Sieck
Gary Sieck
Joey P Granger,Susan M Barman,Kim E Barrett
Joey P Granger
No rest for the weary: diastolic calcium homeostasis in the normal and failing myocardium [0.03%]
未有疲惫者得享安息：正常和衰竭心肌中的舒张期钙离子稳态
William E Louch,Mathis K Stokke,Ivar Sjaastad et al.
William E Louch et al.
Following contraction of the heart, efficient relaxation (diastole) is essential for refilling the ventricles with blood. This review describes how ventricular relaxation is controlled by Ca(2+) homeostasis in cardiac muscle cells and how a...
Regulation of metabolism: a cross talk between gut microbiota and its human host [0.03%]
代谢调节：肠道菌群与宿主的相互作用
Rémy Burcelin
Rémy Burcelin
The recent epidemic of obesity and diabetes and the diversity at the individual level could be explained by the intestinal microbiota-to-host relationship. More than four million gene products from the microbiome could interact with the imm...
The WNK/SPAK and IRBIT/PP1 pathways in epithelial fluid and electrolyte transport [0.03%]
上皮细胞液量和电解质转运的WNK / SPAK和IRBIT / PP1通路
Seonghee Park,Jeong Hee Hong,Ehud Ohana et al.
Seonghee Park et al.
Fluid and electrolyte homeostasis is a fundamental physiological function required for survival and is associated with a plethora of diseases when aberrant. Systemic fluid and electrolyte composition is regulated by the kidney, and all secr...