T Hoshi,A Pantazis,R Olcese
T Hoshi
Large-conductance Ca2+ -and voltage-gated K+ channels are activated by an increase in intracellular Ca2+ concentration and/or depolarization. The channel activation mechanism is well described by an allosteric model encompassing the gate, v...
Membrane-tethered ligands: tools for cell-autonomous pharmacological manipulation of biological circuits [0.03%]
膜连接配体：用于细胞自主药理学操控生物电路的工具
Charles Choi,Michael N Nitabach
Charles Choi
Detection of secreted signaling molecules by cognate cell surface receptors is a major intercellular communication pathway in cellular circuits that control biological processes. Understanding the biological significance of these connection...
Nogo-A represses anatomical and synaptic plasticity in the central nervous system [0.03%]
Nogo-A 抑制中枢神经系统的解剖和突触可塑性
Anissa Kempf,Martin E Schwab
Anissa Kempf
Nogo-A was initially discovered as a myelin-associated growth inhibitory protein limiting axonal regeneration after central nervous system (CNS) injury. This review summarizes current knowledge on how myelin and neuronal Nogo-A and its rece...
Hairy sensation [0.03%]
毛茸茸的感觉
Stefan G Lechner,Gary R Lewin
Stefan G Lechner
The hairs of the skin not only function to prevent heat loss but also have important sensory functions. Recent work has now established that each hair of the skin is innervated by one or more of three types of mechanoreceptor ending. Each o...
Gary Sieck
Gary Sieck
Gary C Sieck,Carlos Mantilla,Jill Barnes et al.
Gary C Sieck et al.
Physiology and redundancy [0.03%]
生理学与冗余性
Michael J Joyner
Michael J Joyner
Endothelial fatty acid transport: role of vascular endothelial growth factor B [0.03%]
内皮脂肪酸转运：血管内皮生长因子B的作用
Carolina Hagberg,Annika Mehlem,Annelie Falkevall et al.
Carolina Hagberg et al.
Dietary lipids present in the circulation have to be transported through the vascular endothelium to be utilized by tissue cells, a vital mechanism that is still poorly understood. Vascular endothelial growth factor B (VEGF-B) regulates thi...
Irene Trinh,Gabrielle L Boulianne
Irene Trinh
In recent years, obesity has been recognized as a major public health problem due to its increased prevalence in both children and adults and its association with numerous life-threatening complications including diabetes, heart disease, hy...
Proteins and mechanisms regulating gap-junction assembly, internalization, and degradation [0.03%]
调控缝隙连接组装、内吞和降解的蛋白质与机制
Anastasia F Thévenin,Tia J Kowal,John T Fong et al.
Anastasia F Thévenin et al.
Gap junctions (GJs) are the only known cellular structures that allow a direct cell-to-cell transfer of signaling molecules by forming densely packed arrays or "plaques" of hydrophilic channels that bridge the apposing membranes of neighbor...