Carmen Fiuza-Luces,Nuria Garatachea,Nathan A Berger et al.
Carmen Fiuza-Luces et al.
The concept of a "polypill" is receiving growing attention to prevent cardiovascular disease. Yet similar if not overall higher benefits are achievable with regular exercise, a drug-free intervention for which our genome has been haped over...
Sylvie Breton,Dennis Brown
Sylvie Breton
Specialized cells in the body express high levels of V-ATPase in their plasma membrane and respond to hormonal and nonhormonal cues to regulate extracellular acidification. Mutations in or loss of some V-ATPase subunits cause several disord...
Mapping and modeling gastrointestinal bioelectricity: from engineering bench to bedside [0.03%]
胃肠生物电的测绘与建模：从工程实验到临床应用
L K Cheng,P Du,G O&#x;Grady
L K Cheng
A key discovery in gastrointestinal motility has been the central role played by interstitial cells of Cajal (ICC) in generating electrical slow waves that coordinate contractions. Multielectrode mapping and multiscale modeling are two emer...
Shady Saad,Matthias Peter,Reinhard Dechant
Shady Saad
Although nutrient availability is a major driver of cell growth, and continuous adaptation to nutrient supply is critical for the development and survival of all organisms, the molecular mechanisms of nutrient sensing are only beginning to ...
W Michael Panneton
W Michael Panneton
The mammalian diving response is a remarkable behavior that overrides basic homeostatic reflexes. It is most studied in large aquatic mammals but is seen in all vertebrates. Pelagic mammals have developed several physiological adaptations t...
P T Madsen,A Surlykke
P T Madsen
Echolocating bats and toothed whales hunt and navigate by emission of sound pulses and analysis of returning echoes to form a self-generated auditory scene. Here, we demonstrate a striking functional convergence in the way these two groups ...
Gary C Sieck,Tobias Wang,Christopher T Minson et al.
Gary C Sieck et al.
Daniel A Beard
Daniel A Beard
Modulation of soluble guanylate cyclase for the treatment of erectile dysfunction [0.03%]
用于治疗勃起功能障碍的可溶性鸟苷酸环化酶调节剂
George F Lasker,Edward A Pankey,Philip J Kadowitz
George F Lasker
Nitric oxide (NO) is the principal mediator of penile erection, and PDE-5 inhibitors are the first-line agents used to treat erectile dysfunction (ED). When NO formation or bioavailability is decreased by oxidative stress and PDE-5 inhibito...