From cells to selves and back: human neurodiversity at single cell resolution [0.03%]
从细胞到自我再到细胞：单细胞分辨率下的人类神经多样性
Manuel Lessi,Nicolò Caporale,Giuseppe Testa
Manuel Lessi
Human brain development is characterized by a complex cellular and molecular landscape, which vary both within and between individuals. Here we explore the transformative impact of single-cell omics technologies on our understanding of huma...
Nikki Forrester
Nikki Forrester
The immunopathophysiology of organ fibrosis: From mechanisms to immunotherapies [0.03%]
器官纤维化的免疫病理生理学：从机制到免疫疗法
Jingyi He,Irina Ferapontova,Jing Chen et al.
Jingyi He et al.
Fibrosis is the ultimate outcome of various chronic diseases that affect multiple organs, including the liver, lungs, heart, and kidneys. This pathological process is characterized by the excessive accumulation of extracellular matrix produ...
Molecular and Inflammatory Etiologies of ß Cell Dysfunction in Type 1 Diabetes [0.03%]
1型糖尿病的β细胞功能障碍的分子和炎症病因学
Cameron R Rostron,Carmella Evans-Molina
Cameron R Rostron
Type 1 diabetes (T1D) is a metabolic disease caused by the autoimmune-mediated destruction of pancreatic β cells; however, recent findings indicate that intrinsic stress pathways within β cells may contribute to the initiation or perpetua...
The nose knows: Olfaction as a metabolic gatekeeper in health and disease [0.03%]
识鼻为知：嗅觉在健康和疾病中的代谢守门人作用
Diogo Manoel,Eman Abou Moussa,Asma Al-Naama et al.
Diogo Manoel et al.
Long regarded as an accessory sense, olfaction is now emerging as a metabolic architect-an active agent in energy homeostasis, appetite regulation, and systemic physiology. This review explores the converging lines of evidence positioning t...
Rich Gang Li,Fansen Meng,James F Martin
Rich Gang Li
Ischemic heart disease, which affects more than 200 million people worldwide, is caused by reduced blood flow to the heart and leads to widespread cardiomyocyte death. Due to the limited regenerative potential of cardiomyocytes, the lost ti...
MFSD2A in focus: the molecular mechanism of omega-3 fatty acid transport [0.03%]
MFSD2A受关注的原因：Omega-3脂肪酸转运的分子机制
Farrah Blades,Aysenur Torun Yazici,Rosemary Jane Cater et al.
Farrah Blades et al.
Omega-3 fatty acids, such as docosahexaenoic acid (DHA), are essential nutrients required to support growth, maintenance, and function of the central nervous system (CNS). While the brain has a high demand for DHA, it cannot synthesize it d...
Nikki Forrester
Nikki Forrester
Lewis H Ziska
Lewis H Ziska
There is a fundamental need to consider plant physiology in relation to human health as it encompasses a number of often overlooked issues, from plant based medicines, to nutrition. The goal here is to provide a historical narrative of plan...
Harnessing Computational Strategies to Overcome Challenges in mRNA Vaccines [0.03%]
利用计算策略来克服mRNA疫苗中的挑战
Siyu Zhao,Jingjing Chen,Tian Dai et al.
Siyu Zhao et al.
In recent years, the introduction of mRNA vaccines for SARS-CoV2 and RSV has highlighted the success of the mRNA technology platform. Designing mRNA sequences involves multiple components and requires balancing several parameters, including...