Cocaine-Induced Cardiovascular and Immune Dysfunction: Emerging Mechanisms [0.03%]
可卡因诱导的心血管和免疫功能障碍：新兴机制
Kyce Darouiche,Shelby Devin,Silvana Valdebenito et al.
Kyce Darouiche et al.
Substance use and its associated comorbidities are a global public health crisis affecting millions of people, involving both legal and illicit substances, including cocaine, opioids, methamphetamine, fentanyl, alcohol, and marijuana. Curre...
Shagufta Haque,Partha Dutta
Shagufta Haque
The heart-brain axis forms an important physiological network, which is increasingly gaining recognition due to its involvement in cardiac function under steady-state conditions and pathological modifications of the heart in cardiovascular ...
Autonomic mechanisms of blood pressure control in females across the lifespan [0.03%]
女性一生中心血管自主神经机制与血压调节
Qi Fu
Qi Fu
This review summarizes current knowledge on autonomic cardiovascular function, with a focus on sympathetic neural control, in human females across the lifespan in health and disease. Specifically, sympathetic activity at rest and during str...
The Molecular Foundations of High Heart Rates: Sarcomeric Protein Adaptations [0.03%]
高心率的分子基础：肌丝蛋白适应性变化
William Joyce
William Joyce
From shrews to whales, mammals exhibit a range of heart rates that varies more than 100-fold. Whilst the fundamental processes of cardiac contraction are conserved, the repertoire of contractile proteins of the sarcomere must be optimized t...
Nikki Forrester
Nikki Forrester
Kimberly L Dodge-Kafka,Moriah Gildart Turcotte,Sofia M Possidento et al.
Kimberly L Dodge-Kafka et al.
Canonical activation of G-protein coupled receptors (GPCRs) by hormone binding occurs at the plasma membrane, resulting in the diffusion of second messengers to intracellular effector sites throughout the cell. In contrast, recent evidence ...
Jing Chen,Yijia Xu,Peng Cao
Jing Chen
Accumulating evidence highlights the crucial role of the gut-brain axis in diseases. This bidirectional signaling connects the gastrointestinal tract (GI) and the brain via neural, immune, and endocrine pathways, orchestrating a range of ph...
What do we know of human fuel use during aerobic exercise and how do we know it? [0.03%]
有氧运动中人类能量底物利用的研究进展及展望
Jessie Axsom,Zolt Arany
Jessie Axsom
Aerobic exercise is arguably the most metabolically demanding challenge imposed on the human body. The metabolic adaptations to exercise are complex, involving most tissues, and differing substantially depending on the type, severity, and d...
Osama F Harraz,Ahmed M Hashad
Osama F Harraz
The brain relies on an intricate vascular network to deliver oxygen and nutrients through functional hyperemia, a process critical for matching blood flow to neuronal activity. This review explores the roles of ion channels in brain capilla...
Cigdem Sahin,Yu-Hua Tseng
Cigdem Sahin
Thermogenic adipose tissues, including brown and beige, exhibit remarkable cellular and metabolic adaptations to environmental and physiological cues, contributing to improved metabolic health. Among these adaptations, adipose progenitor ce...