Atul Malhotra,Naomi Deacon,Frank Powell et al.
Atul Malhotra et al.
Soga Sofola
Soga Sofola
Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides [0.03%]
磷二酯酶通过环核苷酸区室化维持信号保真度
Oliver Lomas,Manuela Zaccolo
Oliver Lomas
Novel technological advances have improved our understanding of how cyclic nucleotides are able to convey signals faithfully between cellular compartments. Phosphodiesterases play a crucial role in shaping these signals in health and diseas...
Andrey Gourine,Alexander V Gourine
Andrey Gourine
This review highlights the importance of neural mechanisms capable of protecting the heart against lethal ischemia/reperfusion injury. Increased parasympathetic (vagal) activity limits myocardial infarction, and recent data suggest that act...
Suttira Intapad,Norma B Ojeda,John Henry Dasinger et al.
Suttira Intapad et al.
The Developmental Origins of Health and Disease (DOHaD) proposes that adverse events during early life program an increased risk for cardiovascular disease. Experimental models provide proof of concept but also indicate that insults during ...
GLP-1-based strategies: a physiological analysis of differential mode of action [0.03%]
基于GLP-1的策略：不同作用机制的生理分析
Rémy Burcelin,Pierre Gourdy,Stéphane Dalle
Rémy Burcelin
DPP4 inhibitors and GLP-1 receptor agonists used in incretin-based strategies treat Type 2 diabetes with different modes of action. The pharmacological blood GLP-1R agonist concentration targets pancreatic and some extrapancreatic GLP-1R, w...
D Grahame Hardie,Michael L J Ashford
D Grahame Hardie
AMP-activated protein kinase appears to have evolved in single-celled eukaryotes as an adenine nucleotide sensor that maintains energy homeostasis at the cellular level. However, during evolution of more complex multicellular organisms, the...
If body fatness is under physiological regulation, then how come we have an obesity epidemic? [0.03%]
如果脂肪含量受生理调节，那么肥胖流行病又是怎么回事？
John R Speakman
John R Speakman
Life involves a continuous use of energy, but food intake, which supplies that energy, is episodic. Feeding is switched on and off by a complex array of predominantly gut-derived peptides (and potentially nutrients) that initiate and termin...
Gary Sieck
Gary Sieck
Adrian Vella
Adrian Vella